{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:07:17Z","timestamp":1792271237986,"version":"4.4.0"},"reference-count":25,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: For nearly 15 years, carbon dioxide (CO2) laser has been the gold standard in skin rejuvenation. Aim: The purpose of this study was to assess the efficacy of a new laser device which combines CO2 and 1540 nm wavelengths in wrinkles reduction, using a recently developed scanning unit named the \u00b5Scan DOT scanner. Materials and Methods: A total of 20 female patients underwent from two to four laser treatment sessions performed once every 45\u201390 days. Wrinkles reduction was evaluated using the Fitzpatrick Wrinkle Classification System (FWCS). Evaluations of five-point Global Patient\u2019s Assessment (PGA) and an Oedema and Erythema index based on a four-point scale were carried out. A careful photographic evaluation was performed to observe the patients\u2019 aesthetic improvements. All the assessments were performed before and at 3 months follow up (3 MFU) after the last treatment session. Results: The mean FWCS score significantly (p &lt; 0.01) decreased from 5.45 \u00b1 2.21 at baseline to 3.3 \u00b1 1.78 at 3 MFU after the last treatment session. In total, 8\/20 (40%) subjects reported excellent improvement, 7\/20 (35%) subjects showed good improvement, 5\/20 (25%) subjects showed slight improvement, and 0\/20 (0%) subjects showed no improvement. Concerning the Oedema index, 15\/20 subjects experienced a mild one, 5\/20 subjects experienced a moderate one, and none of 20 experienced a severe one, while for the Erythema index, 1\/20 patients experienced mild, 18\/20 patients experienced moderate, and only 1\/20 patient experienced severe erythema. No severe adverse events were observed. Conclusions: This dual-wavelength laser technique may become a promising new option for safe, nonsurgical improvement for skin rejuvenation with an extremely low risk of scarring or hypopigmentation and shorter healing times.<\/jats:p>","DOI":"10.3390\/medicina59101857","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T05:43:28Z","timestamp":1697694208000},"page":"1857","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Laser Impacts on Skin Rejuvenation: The Use of a Synergistic Emission of CO2 and 1540 nm Wavelengths"],"prefix":"10.3390","volume":"59","author":[{"given":"Stefania","family":"Belletti","sequence":"first","affiliation":[{"name":"Private Practice, Studio Kalos, 20100 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5386-7656","authenticated-orcid":false,"given":"Francesca","family":"Madeddu","sequence":"additional","affiliation":[{"name":"El.En. Group, 50041 Calenzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Brando","sequence":"additional","affiliation":[{"name":"Berner Klinik Montana, 3963 Crans-Montana, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Provenzano","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Cosenza Hospital, 87100 Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven Paul","family":"Nistic\u00f2","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Rome \u201cLa Sapienza\u201d, 00185 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Fusco","sequence":"additional","affiliation":[{"name":"El.En. Group, 50041 Calenzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0434-1027","authenticated-orcid":false,"given":"Luigi","family":"Bennardo","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.asj.2009.05.004","article-title":"Fractionated CO2 laser resurfacing: Our experience with more than 2000 treatments","volume":"29","author":"Hunzeker","year":"2009","journal-title":"Aesthetic Surg. 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