{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:31:08Z","timestamp":1777897868105,"version":"3.51.4"},"reference-count":26,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007700","name":"University of Medicine and Pharmacy Carol Davila","doi-asserted-by":"publisher","award":["Publish not Perish"],"award-info":[{"award-number":["Publish not Perish"]}],"id":[{"id":"10.13039\/501100007700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Congenital hypothyroidism (CH) may have major detrimental effects on growth and neurological development, but early intervention leads to excellent outcomes. CH is classified as transient or permanent, primary or secondary, with primary CH being the most common neonatal endocrine disorder. Most patients with CH do not present any typical signs and symptoms of hypothyroidism shortly after birth, partly due to transplacental maternal thyroid hormone transfer and residual neonatal thyroid function. This paper reports on two CH cases. During the initial Neonatal Intensive Care Unit (NICU) admission phase, CH was not suspected due to nonspecific signs. The distinct characteristics of our cases are as follows: both infants were admitted to the NICU for respiratory distress syndrome, requiring invasive mechanical ventilation, and both were born to diabetic mothers. Following extubation, they both showed similar neurological issues, including reduced muscle tone and feeding difficulties. Initially, those symptoms were attributed to delayed clearance of analgesic and sedative medication. However, symptoms progressively worsened over time. Subsequent tests revealed both meeting CH diagnostic criteria: an unusual ultrasound indicating thyroid agenesis and abnormal hormone levels. Guided by the pediatric endocrinology team, prompt hormonal treatment was started with improvements in neurocognitive function and feeding. Usually, CH screening involves blood samples from healthy newborns at 2\u20133 days of life. Abnormal results require confirmation, prompting treatment within two weeks. Certain NICU-admitted infants face higher diagnosis delays, as seen in those two cases where CH screening was postponed. Thus, for all neonates with persistent pathologies unresponsive to standard etiological treatment, conducting a comprehensive anamnestic evaluation of the medical history, along with maternal preconceptional and prenatal nutrition, is recommended.<\/jats:p>","DOI":"10.3390\/medicina59101887","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T10:32:24Z","timestamp":1698057144000},"page":"1887","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Two Cases of Congenital Hypothyroidism Revealing Thyroid Agenesis"],"prefix":"10.3390","volume":"59","author":[{"given":"Leonard","family":"N\u0103stase","sequence":"first","affiliation":[{"name":"Neonatology Department, National Institute for Mother and Child Health \u201cAlessandrescu-Rusescu\u201d, 011061 Bucharest, Romania"},{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Octaviana","family":"Cristea","sequence":"additional","affiliation":[{"name":"Neonatology Department, National Institute for Mother and Child Health \u201cAlessandrescu-Rusescu\u201d, 011061 Bucharest, Romania"},{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6737-6307","authenticated-orcid":false,"given":"Alexandra","family":"Diaconu","sequence":"additional","affiliation":[{"name":"Neonatology Department, National Institute for Mother and Child Health \u201cAlessandrescu-Rusescu\u201d, 011061 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia-Maria","family":"Stoicescu","sequence":"additional","affiliation":[{"name":"Neonatology Department, National Institute for Mother and Child Health \u201cAlessandrescu-Rusescu\u201d, 011061 Bucharest, Romania"},{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0267-735X","authenticated-orcid":false,"given":"Ramona","family":"Mohora","sequence":"additional","affiliation":[{"name":"Neonatology Department, National Institute for Mother and Child Health \u201cAlessandrescu-Rusescu\u201d, 011061 Bucharest, Romania"},{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1079-6028","authenticated-orcid":false,"given":"Bogdan Mihai","family":"Pascu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Endocrinology Department, National Institute for Mother and Child Health \u201cAlessandrescu-Rusescu\u201d, 020395 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona Tania","family":"Tala","sequence":"additional","affiliation":[{"name":"Endocrinology Department, National Institute for Mother and Child Health \u201cAlessandrescu-Rusescu\u201d, 020395 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana","family":"Ro\u0219ca","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Neonatology Department, Clinical Hospital of Obstetrics and Gynecology \u201cProf. Dr. P. S\u00e2rbu\u201d, 060251 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s40272-017-0238-0","article-title":"Pediatric Hypothyroidism: Diagnosis and Treatment","volume":"19","author":"Wassner","year":"2017","journal-title":"Pediatr. 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