{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:07:50Z","timestamp":1779912470809,"version":"3.53.1"},"reference-count":14,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background: Acute mesenteric ischemia (AMI) is a life-threatening condition, and in 50% of patients, AMI is caused by acute superior mesenteric artery (SMA) embolism. Endovascular treatment is increasingly being considered the primary modality in selected cases. Many studies have reported that percutaneous aspiration embolectomy using a guiding catheter and thrombolysis with recombinant tissue plasminogen activator (rtPA) are effective in treating SMA embolism. However, no reports on treating SMA embolism using rtPA administered via a microcatheter exist. Case presentation: A 64-year-old man with underlying atrial fibrillation presented with acute SMA embolism revealed using computed tomography (CT). rtPA (total 3 mg) was carefully administered into the occluded SMA through a microcatheter. No complications occurred, and complete revascularization of the SMA was revealed on follow-up CT. Conclusions: Compared with previous reports, this case report reveals that successful revascularization can be achieved using rtPA administered via a microcatheter, with a low dose of rtPA and a short duration of thrombolysis.<\/jats:p>","DOI":"10.3390\/medicina59111889","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T06:28:25Z","timestamp":1698128905000},"page":"1889","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Microcatheter-Directed Thrombolysis Using Recombinant Tissue Plasminogen Activator for the Treatment of Acute Superior Mesenteric Artery Embolism: A Case Report"],"prefix":"10.3390","volume":"59","author":[{"given":"Yang-Won","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Radiology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju 52727, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Cheol","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju 52727, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Jeong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju 52727, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong-Ju","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju 52727, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Kyeong","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju 52727, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Pyo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju 52727, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Bum","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju 52727, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa-Hong","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon 51472, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Eun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon 51472, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Ho","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju 52727, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s13244-018-0641-2","article-title":"Acute Mesenteric Ischaemia: A Pictorial Review","volume":"9","author":"Florim","year":"2018","journal-title":"Insights Imaging"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1056\/NEJMra1503884","article-title":"Mesenteric Ischemia","volume":"374","author":"Clair","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13017-022-00443-x","article-title":"Acute Mesenteric Ischemia: Updated Guidelines of the World Society of Emergency Surgery","volume":"17","author":"Bala","year":"2022","journal-title":"World. J. Emerg. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S0016-5085(00)70183-1","article-title":"AGA technical review on intestinal ischemia. American Gastrointestinal Association","volume":"118","author":"Brandt","year":"2000","journal-title":"Gastroenterology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jvs.2013.06.084","article-title":"3rd. Comparison of Open and Endovascular Treatment of Acute Mesenteric Ischemia","volume":"59","author":"Beaulieu","year":"2014","journal-title":"J. Vasc. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e14446","DOI":"10.1097\/MD.0000000000014446","article-title":"Review: Acute Superior Mesenteric Artery Embolism: A Vascular Emergency Cannot be Ignored by Physicians","volume":"98","author":"Liao","year":"2019","journal-title":"Medicine"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1007\/s00270-009-9559-x","article-title":"Endovascular Therapeutic Approaches for Acute Superior Mesenteric Artery Occlusion","volume":"32","author":"Acosta","year":"2009","journal-title":"Cardiovasc. Intervent. Radiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/01.RVI.0000141719.24321.0B","article-title":"Thrombolytic Therapy for Acute Superior Mesenteric Artery Occlusion","volume":"16","author":"Schoots","year":"2005","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3348\/kjr.2015.16.4.736","article-title":"Percutaneous Aspiration Embolectomy Using Guiding Catheter for the Superior Mesenteric Artery Embolism","volume":"16","author":"Choi","year":"2015","journal-title":"Korean J. Radiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1007\/s00330-010-1859-7","article-title":"Primary Percutaneous Aspiration and Thrombolysis for the Treatment of Acute Embolic Superior Mesenteric Artery Occlusion","volume":"20","author":"Heiss","year":"2010","journal-title":"Eur. Radiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.avsg.2018.07.061","article-title":"Outcomes of Brachial Artery Access for Endovascular Interventions","volume":"56","author":"Madden","year":"2019","journal-title":"Ann. Vasc. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.jvs.2011.07.054","article-title":"Thrombolysis for Acute Occlusion of the Superior Mesenteric Artery","volume":"54","author":"Block","year":"2011","journal-title":"J. Vasc. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Lin, B.C., Wu, C.H., Wong, Y.C., Hung, S.C., and Hsin, M.C. (2023). Intra-Arterial Urokinase for Acute Superior Mesenteric Artery Occlusion: A Retrospective 12-Year Report of 13 Cases. Biomedicines, 11.","DOI":"10.3390\/biomedicines11020267"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1067\/mva.2003.41","article-title":"The Safety, Efficacy, and Pharmacoeconomics of Low-Dose RtPA Compared with Urokinase for Catheter-Directed Thrombolysis of Arterial and Venous Occlusions","volume":"37","author":"Sugimoto","year":"2003","journal-title":"J. Vasc. 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