{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:37:04Z","timestamp":1760150224937,"version":"build-2065373602"},"reference-count":41,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Hearing loss after septicemia has been found in mice; the long-term risk increased 50-fold in young adults in a previous study. Hearing loss after septicemia has not received much attention. The aim of this study was to assess the relationship between septicemia and subsequent hearing loss. Materials and Methods: Inpatient data were obtained from the Taiwan Insurance Database. We defined patients with sensorineural hearing loss and excluded patients under 18 years of age. Patients without hearing loss were selected as controls at a frequency of 1:5. The date of admission was defined as the date of diagnosis. Comorbidities in the 3 years preceding the date of diagnosis were retrieved retrospectively. Associations with hearing loss were established by multiple logistic regression and forward stepwise selection. Results: The odds ratio (OR) for the association between sepsis and hearing loss was 3.052 (95% CI: 1.583\u20135.884). Autoimmune disease (OR: 5.828 (95% CI: 1.906\u201317.816)), brain injury (OR: 2.264 (95% CI: 1.212\u20134.229)) and ischemic stroke (OR: 1.47 (95% CI: 1.087\u20131.988)) were associated with hearing loss. Conclusions: Our study shows that hearing loss occurred after septicemia. Apoptosis caused by sepsis and ischemia can lead to hair cell damage, leading to hearing loss. Clinicians should be aware of possible subsequent complications of septicemia and provide appropriate treatment and prevention strategies for complications.<\/jats:p>","DOI":"10.3390\/medicina59111897","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T06:20:16Z","timestamp":1698301216000},"page":"1897","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Underestimated Subsequent Sensorineural Hearing Loss after Septicemia"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1081-760X","authenticated-orcid":false,"given":"Chun-Gu","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Emergency, Taoyuan Armed Forces General Hospital, Taoyuan 32549, Taiwan"},{"name":"Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hsuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Chest Medicine, Department of Internal Medicine, Cheng Hsin General Hospital, Taipei 11220, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin-Han","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Psychology, National Taiwan University, Taipei 10621, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Nursing, College of Nursing, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pi-Wei","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Nursing, Ministry of Health and Welfare, Hua-Lien Hospital, Hualien 97061, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6885-2523","authenticated-orcid":false,"given":"Yen-Yue","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Emergency, Taoyuan Armed Forces General Hospital, Taoyuan 32549, Taiwan"},{"name":"Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Chi","family":"Yung","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Taiwan Adventist Hospital, Taipei 10540, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0380-7286","authenticated-orcid":false,"given":"Chun-An","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1001\/jama.2011.1615","article-title":"Incident stroke and mortality associated with new-onset atrial fibrillation in patients hospitalized with severe sepsis","volume":"306","author":"Walkey","year":"2011","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/qjmed\/hcx025","article-title":"New-Onset Atrial Fibrillation Related Ischemic Stroke Occurring after Hospital Discharge in Septicemia Survivors","volume":"110","author":"Cheng","year":"2017","journal-title":"QJM"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1378\/chest.14-0003","article-title":"Long-term outcomes following development of new-onset atrial fibrillation during sepsis","volume":"146","author":"Walkey","year":"2014","journal-title":"Chest"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"963955","DOI":"10.3389\/fimmu.2022.963955","article-title":"Dysregulation of neutrophil death in sepsis","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S1473-3099(17)30117-2","article-title":"Application of the Third International Consensus Definitions for Sepsis (Sepsis-3) Classification: A retrospective population-based cohort study","volume":"17","author":"Donnelly","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1001\/jamaoto.2016.3527","article-title":"Declining Prevalence of Hearing Loss in US Adults Aged 20 to 69 Years","volume":"143","author":"Hoffman","year":"2017","journal-title":"JAMA Otolaryngol.\u2013Head Neck Surg."},{"key":"ref_7","first-page":"745","article-title":"Sepsis otopathy: Experimental sepsis leads to significant hearing impairment due to apoptosis and glutamate excitotoxicity in murine cochlea","volume":"6","author":"Schmutzhard","year":"2013","journal-title":"Dis. Models Mech."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1242\/bio.028761","article-title":"Surviving murine experimental sepsis affects the function and morphology of the inner ear","volume":"6","author":"Fischer","year":"2017","journal-title":"Biol. Open"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.heares.2012.11.010","article-title":"Changes in the adult vertebrate auditory sensory epithelium after trauma","volume":"297","author":"Oesterle","year":"2013","journal-title":"Hear. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e21050","DOI":"10.1097\/MD.0000000000021050","article-title":"Hearing impairment in young and middle-aged septicemia survivors","volume":"99","author":"Cheng","year":"2020","journal-title":"Medicine"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1007\/s10495-023-01874-w","article-title":"The intricate relationship between autoimmunity disease and neutrophils death patterns: A love-hate story","volume":"28","author":"Zhang","year":"2023","journal-title":"Apoptosis"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1090672","DOI":"10.3389\/fnins.2023.1090672","article-title":"Traumatic brain injury: Mechanisms, manifestations, and visual sequelae","volume":"17","author":"Rauchman","year":"2023","journal-title":"Front. Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/med.21817","article-title":"Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications","volume":"42","author":"Tuo","year":"2022","journal-title":"Med. Res. Rev."},{"key":"ref_14","first-page":"1","article-title":"Risk factors for hearing loss in infants under universal hearing screening program in Northern Thailand","volume":"9","author":"Poonual","year":"2016","journal-title":"J. Multidiscip. Healthc."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Iwata, A., de Claro, R.A., Morgan-Stevenson, V.L., Tupper, J.C., Schwartz, B.R., Liu, L., Zhu, X., Jordan, K.C., Winn, R.K., and Harlan, J.M. (2011). Extracellular administration of BCL2 protein reduces apoptosis and improves survival in a murine model of sepsis. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0014729"},{"key":"ref_16","first-page":"e18421","article-title":"Audiovestibular Symptoms at the Intensive Care Unit: A Narrative Review","volume":"13","author":"Escobar","year":"2021","journal-title":"Cureus"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1139\/Y09-012","article-title":"Impaired regulation of cardiac function in sepsis, SIRS, and MODS This article is one of a selection of papers from the NATO Advanced Research Workshop on Translational Knowledge for Heart Health (published in part 2 of a 2-part Special Issue)","volume":"87","author":"Werdan","year":"2009","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"R140","DOI":"10.1186\/cc9205","article-title":"Cerebral microcirculation is impaired during sepsis: An experimental study","volume":"14","author":"Taccone","year":"2010","journal-title":"Crit. Care"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/MBC.0b013e328201c77e","article-title":"Inflammatory changes during the \u2018common cold\u2019 are associated with platelet activation and increased reactivity of platelets to agonists","volume":"18","author":"Kreutz","year":"2007","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1177\/0300060516688600","article-title":"Systemic Lupus Erythematosus and hearing disorders: Literature review and meta-analysis of clinical and temporal bone findings","volume":"45","author":"Ralli","year":"2017","journal-title":"J. Int. Med. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/lio2.28","article-title":"AAO: Autoimmune and Autoinflammatory (Disease) in Otology: What is New in Immune-Mediated Hearing Loss","volume":"1","author":"Vambutas","year":"2016","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1093\/rheumatology\/ket009","article-title":"Autoimmune sensorineural hearing loss: The otology\u2013rheumatology interface","volume":"52","author":"Mijovic","year":"2013","journal-title":"Rheumatology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4841","DOI":"10.1097\/MD.0000000000004841","article-title":"Risk of sudden sensorineural hearing loss in stroke patients: A 5-year nationwide investigation of 44,460 patients","volume":"95","author":"Kuo","year":"2016","journal-title":"Medicine"},{"key":"ref_24","first-page":"97","article-title":"Neuroinflammatory responses to traumatic brain injury: Etiology, clinical consequences, and therapeutic opportunities","volume":"11","author":"Lozano","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1002\/lary.26567","article-title":"Increased long-term risk of hearing loss in patients with traumatic brain injury: A nationwide population-based study","volume":"127","author":"Shangkuan","year":"2017","journal-title":"Laryngoscope"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0140-6736(10)60834-3","article-title":"Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): A case-control study","volume":"376","author":"Xavier","year":"2010","journal-title":"Lancet"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1097\/WNR.0b013e32833da3c3","article-title":"Changes in guinea pig cochlea after transient cochlear ischemia","volume":"21","author":"Lin","year":"2010","journal-title":"Neuroreport"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.heares.2015.05.004","article-title":"Sensorineural hearing loss and ischemic injury: Development of animal models to assess vascular and oxidative effects","volume":"327","author":"Olivetto","year":"2015","journal-title":"Hear. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1001\/jamaoto.2016.0845","article-title":"Association of sudden sensorineural hearing loss with vertebrobasilar insufficiency","volume":"142","author":"Hsu","year":"2016","journal-title":"JAMA Otolaryngol.\u2013Head Neck Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1086\/656409","article-title":"Factors associated with the occurrence of hearing loss after pneumococcal meningitis","volume":"51","author":"Brandt","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1038\/s41598-023-28599-9","article-title":"Relationship of cardiovascular disease risk and hearing loss in a clinical population","volume":"13","author":"Baiduc","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_32","first-page":"1150","article-title":"Hearing loss in older adults","volume":"85","author":"Walling","year":"2012","journal-title":"Am. Fam. Physician"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1542\/peds.112.5.1049","article-title":"Hearing loss at school age in survivors of bacterial meningitis: Assessment, incidence, and prediction","volume":"112","author":"Koomen","year":"2003","journal-title":"Pediatrics"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1542\/peds.114.1.e111","article-title":"Extended-interval aminoglycoside administration for children: A meta-analysis","volume":"114","author":"Giotis","year":"2004","journal-title":"Pediatrics"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jdiacomp.2018.04.004","article-title":"Association between diabetes mellitus and hearing impairment in American and Korean populations","volume":"32","author":"Moon","year":"2018","journal-title":"J. Diabetes Complicat."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1001\/jamaoto.2016.3631","article-title":"Association of Iron Deficiency Anemia with Hearing Loss in US Adults","volume":"143","author":"Schieffer","year":"2016","journal-title":"JAMA Otolaryngol.\u2013Head Neck Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1097\/CCM.0b013e318246b9df","article-title":"Acetyl salicylic acid usage and mortality in critically ill patients with the systemic inflammatory response syndrome and sepsis","volume":"40","author":"Eisen","year":"2012","journal-title":"Crit. Care Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1001\/jama.2013.278477","article-title":"Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: A randomized clinical trial","volume":"310","author":"Morelli","year":"2013","journal-title":"JAMA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1469-0691.2009.02750.x","article-title":"Statins for sepsis: A critical and updated review","volume":"15","author":"Kopterides","year":"2009","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/bmb\/ldh041","article-title":"Vaccines against bacterial meningitis","volume":"72","author":"Segal","year":"2004","journal-title":"Br. Med. Bull."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"153124","DOI":"10.1016\/j.scitotenv.2022.153124","article-title":"Long-term exposure to ambient air pollutants and hearing loss in Korean adults","volume":"820","author":"Ju","year":"2022","journal-title":"Sci. Total Environ."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/11\/1897\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:12:01Z","timestamp":1760130721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/11\/1897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,26]]},"references-count":41,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["medicina59111897"],"URL":"https:\/\/doi.org\/10.3390\/medicina59111897","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2023,10,26]]}}}