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In East Asia, herbal medicines are often used to treat T2DM, and modified Gangsimtang (mGST) is prescribed to treat a condition called wasting thirst (\u6d88\u6e34), which resembles T2DM. This study reported the treatment of hyperglycemia using herbal medicines without oral hypoglycemic agents or insulin therapy. Case presentation: A 36-year-old man with obesity was diagnosed with T2DM four years prior to hospitalization and experienced blood glucose level reduction from 22.2\u201327.8 mmol\/L (400\u2013500 mg\/dL) to 5.6\u201311.1 mmol\/L (100\u2013200 mg\/dL) by using herbal medicines. He visited D Korean Medicine Hospital with chronic polydipsia and general weakness as chief complaints. He was diagnosed with T2DM on the basis of a hemoglobin A1c level of 11.7% and 2 h postprandial blood glucose level of &gt;25.0 mmol\/L (450 mg\/dL). Moreover, he was diagnosed with a \u201cdual deficiency of qi and yin\u201d (\u6c23\u9670\u5169\u865b) because of ordinary symptoms (\u7d20\u8b49). During his 30-day inpatient treatment, the patient received mGST 120 mL thrice daily; as a result, his postprandial blood glucose level decreased from 25.3 mmol\/L (455 mg\/dL) to 8.6 mmol\/L (154 mg\/dL), polydipsia decreased (visual analog scale score decreased from six to one), and triglyceride levels decreased from 11.7 mmol\/L (1031 mg\/dL) to 2.0 mmol\/L (174 mg\/dL). Plasma glucose levels remained stable for 6 months after the treatment, and no adverse events were observed over 200 days. We administered an herbal decoction to decrease plasma glucose levels without using oral hypoglycemic agents or insulin. Conclusions: Herbal decoctions such as mGST can reduce hyperglycemia in patients with T2DM who refuse conventional therapy.<\/jats:p>","DOI":"10.3390\/medicina59111919","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T12:50:42Z","timestamp":1698670242000},"page":"1919","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hypoglycemic Effect of an Herbal Decoction (Modified Gangsimtang) in a Patient with Severe Type 2 Diabetes Mellitus Refusing Oral Anti-Diabetic Medication: A Case Report"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5508-502X","authenticated-orcid":false,"given":"Sungjun","family":"Joo","sequence":"first","affiliation":[{"name":"Department of Korean Rehabilitation Medicine, Dongshin Korean Medicine Hospital, 351, Omok-ro, Yangcheon-gu, Seoul 07999, Republic of Korea"},{"name":"Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7524-1760","authenticated-orcid":false,"given":"Hyonjun","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Korean Rehabilitation Medicine, Dongshin Korean Medicine Hospital, 351, Omok-ro, Yangcheon-gu, Seoul 07999, Republic of Korea"},{"name":"Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jisu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion, Dongshin Korean Medicine Hospital, 351, Omok-ro, Yangcheon-gu, Seoul 07999, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungmin","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Korean Internal Medicine, Dongshin Korean Medicine Hospital, 351, Omok-ro, Yangcheon-gu, Seoul 07999, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungmin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Korean Rehabilitation Medicine, Dongshin Korean Medicine Hospital, 351, Omok-ro, Yangcheon-gu, Seoul 07999, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3300-5556","authenticated-orcid":false,"given":"Jungtae","family":"Leem","sequence":"additional","affiliation":[{"name":"Research Center of Traditional Korean Medicine, College of Korean Medicine, Wonkwang University, 460, Iksan-daero, Iksan 54538, Jeonbuk, Republic of Korea"},{"name":"Hanbang Cardio-Renal Syndrome Research Center, School of Korean Medicine, Wonkwang University, Iksan 54538, Jeonbuk, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee (2021). 2. 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