{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:05:07Z","timestamp":1792850707519,"version":"4.5.0"},"reference-count":42,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Due to their specific morphology, the regeneration of intrabony defects (IBDs) represents one of the greatest challenges for clinicians. Based on the specific properties of a magnesium membrane, a new approach for the surgical treatment of IBD was developed. The surgical procedure was described using a series of three cases. Materials and Methods: The patients were healthy individuals suffering from a severe form of periodontitis associated with IBD. Based on radiographic examination, the patients had interproximal bone loss of at least 4 mm. Due to its good mechanical properties, it was easy to cut and shape the magnesium membrane into three different shapes to treat the specific morphology of each IBD. In accordance with the principles of guided bone regeneration, a bovine xenograft was used to fill the IBD in all cases. Results: After a healing period of 4 to 6 months, successful bone regeneration was confirmed using radiological analysis. The periodontal probing depth (PPD) after healing showed a reduction of 1.66 \u00b1 0.29 mm. Conclusions: Overall, the use of the different shapes of the magnesium membrane in the treatment of IBD resulted in a satisfactory functional and esthetic outcome.<\/jats:p>","DOI":"10.3390\/medicina59112018","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T07:11:27Z","timestamp":1700118687000},"page":"2018","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Regeneration of Intrabony Defects Using a Novel Magnesium Membrane"],"prefix":"10.3390","volume":"59","author":[{"given":"David Botond","family":"Hangyasi","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64-66, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7340-7632","authenticated-orcid":false,"given":"Gy\u0151z\u0151","family":"K\u00f6rtv\u00e9lyessy","sequence":"additional","affiliation":[{"name":"Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64-66, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Bla\u0161kovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Faculty of Dental Medicine Rijeka, University of Rijeka, Kre\u0161imirova 40\/42, 51 000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3620-7199","authenticated-orcid":false,"given":"Patrick","family":"Rider","sequence":"additional","affiliation":[{"name":"Botiss Biomaterials GmbH, 15806 Zossen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"Rogge","sequence":"additional","affiliation":[{"name":"Botiss Biomaterials GmbH, 15806 Zossen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stjepan","family":"Siber","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, Crkvena 21, 31 000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8250-723X","authenticated-orcid":false,"given":"\u017deljka Peri\u0107","family":"Ka\u010darevi\u0107","sequence":"additional","affiliation":[{"name":"Botiss Biomaterials GmbH, 15806 Zossen, Germany"},{"name":"Department of Anatomy, Histology, Embryology, Pathologic Anatomy and Pathologic Histology, J.J. Strossmayer University of Osijek, Crkvena 21, 31 000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2932-7157","authenticated-orcid":false,"given":"Marija","family":"\u010candrli\u0107","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, Crkvena 21, 31 000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2147\/CCIDE.S166164","article-title":"Optimal management of intrabony defects: Current insights","volume":"11","author":"Shukla","year":"2019","journal-title":"Clin. Cosmet. Investig. Dent."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jds.2020.11.011","article-title":"Clinical classification of tooth position in the alveolar bone housing with periodontal defects","volume":"16","author":"Hasegawa","year":"2021","journal-title":"J. Dent. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jobcr.2020.04.014","article-title":"Minimally invasive periodontal therapy","volume":"10","author":"Sultan","year":"2020","journal-title":"J. Oral Biol. Craniofacial Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"464","DOI":"10.4103\/0972-124X.193164","article-title":"Reconstruction of interdental papilla using autogenous bone and connective tissue grafts","volume":"20","author":"Muthukumar","year":"2016","journal-title":"J. Indian. Soc. Periodontol."},{"key":"ref_5","first-page":"141","article-title":"Root coverage and papilla reconstruction using autogenous osseous and connective tissue grafts","volume":"21","author":"Azzi","year":"2001","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/sj.bdj.2014.1004","article-title":"Management of gingival black triangles","volume":"217","author":"Ziahosseini","year":"2014","journal-title":"Br. Dent. J."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Anoixiadou, S., Parashis, A., and Vouros, I. (2023). Minimally Invasive Non-Surgical Technique in the Treatment of Intrabony Defects\u2014A Narrative Review. Dent. J., 11.","DOI":"10.3390\/dj11010025"},{"key":"ref_8","first-page":"296","article-title":"Black triangle dilemma and its management in esthetic dentistry","volume":"10","author":"Singh","year":"2013","journal-title":"Dent. Res. J."},{"key":"ref_9","first-page":"246","article-title":"Interdental papilla management: A review and classification of the therapeutic approaches","volume":"24","author":"Roberto","year":"2004","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_10","first-page":"CD001724","article-title":"Guided tissue regeneration for periodontal infra-bony defects","volume":"19","author":"Needleman","year":"2006","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4236\/ojst.2018.89026","article-title":"A Comparable Study of Combinational Regenerative Therapies Comprising Enamel Matrix Derivative plus Deproteinized Bovine Bone Mineral with or without Collagen Membrane in Periodontitis Patients with Intrabony Defects","volume":"8","author":"Kubota","year":"2018","journal-title":"Open J. Stomatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1902\/jop.2001.72.2.215","article-title":"Collagen Membranes: A Review","volume":"72","author":"Bunyaratavej","year":"2001","journal-title":"J. Periodontol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/eos.12364","article-title":"Guided bone regeneration: Materials and biological mechanisms revisited","volume":"125","author":"Elgali","year":"2017","journal-title":"Eur. J. Oral Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1902\/jop.2004.75.5.672","article-title":"Long-term tooth survival following regenerative treatment of intrabony defects","volume":"75","author":"Cortellini","year":"2004","journal-title":"J. Periodontol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Elad, A., Rider, P., Rogge, S., Witte, F., Tadi\u0107, D., Ka\u010darevi\u0107, \u017d.P., and Steigmann, L. (2023). Application of Biodegradable Magnesium Membrane Shield Technique for Immediate Dentoalveolar Bone Regeneration. Biomedicines, 11.","DOI":"10.3390\/biomedicines11030744"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.actbio.2018.08.034","article-title":"Design of a migration assay for human gingival fibroblasts on biodegradable magnesium surfaces","volume":"79","author":"Amberg","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_17","first-page":"152","article-title":"Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery","volume":"14","author":"Rider","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Rider, P., Ka\u010darevi\u0107, \u017d.P., Elad, A., Rothamel, D., Sauer, G., Bornert, F., Windisch, P., Hangy\u00e1si, D., Molnar, B., and Hesse, B. (2022). Analysis of a Pure Magnesium Membrane Degradation Process and Its Functionality When Used in a Guided Bone Regeneration Model in Beagle Dogs. Materials, 15.","DOI":"10.3390\/ma15093106"},{"key":"ref_19","first-page":"229","article-title":"Mechanical qualification of collagen membranes used in dentistry","volume":"51","author":"Ortolani","year":"2015","journal-title":"Ann. Ist. Super. Sanita"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.stomax.2010.10.006","article-title":"Propri\u00e9t\u00e9s m\u00e9caniques des membranes de collagne","volume":"111","author":"Placet","year":"2010","journal-title":"Rev. Stomatol. Chir. Maxillofac."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/jbm.1038","article-title":"Physicochemical, mechanical, and biological properties of commercial membranes for GTR","volume":"58","author":"Milella","year":"2001","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/adem.201400434","article-title":"Review of Recent Developments in the Field of Magnesium Corrosion","volume":"17","author":"Atrens","year":"2015","journal-title":"Adv. Eng. Mater."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mser.2014.01.001","article-title":"Biodegradable metals","volume":"77","author":"Zheng","year":"2014","journal-title":"Mater. Sci. Eng. R. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"8199","DOI":"10.3390\/nu7095388","article-title":"Magnesium in prevention and therapy","volume":"7","author":"Schmidt","year":"2015","journal-title":"Nutrients"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1093\/ndtplus\/sfr163","article-title":"Magnesium basics","volume":"5","author":"Ketteler","year":"2012","journal-title":"Clin. Kidney J."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"EFSA NDA Panel (EFSA Panel on Dietetic Products Nutrition and Allergies) (2015). Scientific Opinion on Dietary Reference Values for magnesium. EFSA J., 13, 4186.","DOI":"10.2903\/j.efsa.2015.4186"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Levine, R.A., Saleh, M.H.A., Dias, D.R., Ganeles, J., Ara\u00fajo, M.G., Renouard, F., Pinsky, H.M., Miller, P.D., and Wang, H.-L. (2023). Periodontal Regeneration Risk Assessment in the Treatment of Intrabony Defects. Clin. Adv. Periodontics, 1\u201310.","DOI":"10.1002\/cap.10254"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1600-051X.1997.tb00473.x","article-title":"Guided tissue regeneration with non-resorbable and biodegradable barriers: 6 months results","volume":"24","author":"Eickholz","year":"1997","journal-title":"J. Clin. Periodontol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ren, Y., Fan, L., Alkildani, S., Liu, L., Emmert, S., Najman, S., Rimashevskiy, D., Schnettler, R., Jung, O., and Xiong, X. (2022). Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232314987"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jpor.2012.12.001","article-title":"Current barrier membranes: Titanium mesh and other membranes for guided bone regeneration in dental applications","volume":"57","author":"Rakhmatia","year":"2013","journal-title":"J. Prosthodont. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.actbio.2019.07.022","article-title":"Effect of physical cues of altered extract media from biodegradable magnesium implants on human gingival fibroblasts","volume":"98","author":"Amberg","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_32","first-page":"64","article-title":"Co-implantation of magnesium and zinc ions into titanium regulates the behaviors of human gingival fibroblasts","volume":"6","author":"Wang","year":"2020","journal-title":"Bioact. Mater."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Rider, P., Ka\u010darevi\u0107, \u017d.P., Elad, A., Rothamel, D., Sauer, G., Bornert, F., Windisch, P., Hangy\u00e1si, D., Molnar, B., and Hesse, B. (2022). Biodegradation of a Magnesium Alloy Fixation Screw Used in a Guided Bone Regeneration Model in Beagle Dogs. Materials, 15.","DOI":"10.3390\/ma15124111"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1002\/jbm.b.33113","article-title":"Magnesium biomaterials for orthopedic application: A review from a biological perspective","volume":"102","author":"Walker","year":"2014","journal-title":"J. Biomed. Mater. Res.-Part B Appl. Biomater."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1177\/0885328218822050","article-title":"Degradation and interaction with bone of magnesium alloy WE43 implants: A long-term follow-up in vivo rat tibia study","volume":"33","author":"Oshibe","year":"2019","journal-title":"J. Biomater. Appl."},{"key":"ref_36","first-page":"1","article-title":"A Clinical Comparison of Cenobone (A Decalcified Freeze-dried Bone Allograft) with Autogenous Bone Graft in the Treatment of Two- and Three-wall Intrabony Periodontal Defects: A Human Study with Six-month Reentry","volume":"2","author":"Abolfazli","year":"2008","journal-title":"J. Dent. Res. Dent. Clin. Dent. Prospects"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1034\/j.1600-051X.2003.10192.x","article-title":"Healing of intrabony defects following treatment with a bovine-derived xenograft and collagen membrane","volume":"30","author":"Sculean","year":"2003","journal-title":"J. Clin. Periodontol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-051X.2006.01007.x","article-title":"Five-year results of a prospective, randomized, controlled study evaluating treatment of intra-bony defects with a natural bone mineral and GTR","volume":"34","author":"Sculean","year":"2007","journal-title":"J. Clin. Periodontol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1902\/jop.1995.66.10.838","article-title":"Evaluation of a collagen membrane with and without bone grafts in treating periodontal intrabony defects","volume":"66","author":"Chen","year":"1995","journal-title":"J. Periodontol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4103\/2231-0762.159956","article-title":"Clinical and radiographic evaluation of periodontal intrabony defects by open flap surgery alone or in combination with Biocollagen\u00ae membrane: A randomized clinical trial","volume":"5","author":"Tarakji","year":"2015","journal-title":"J. Int. Soc. Prev. Community Dent."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Lee, I.K., Choi, H.S., Jeong, S.H., and Lee, J.T. (2021). Evaluating Change of Marginal Bone Height with Cone-Beam Computed Tomography Following Surgical Treatment with Guided Tissue Regeneration (Bone Grafting) or Access Flap Alone: A Retrospective Study. Medicina, 57.","DOI":"10.3390\/medicina57090869"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/prd.12504","article-title":"Complications and treatment errors related to regenerative periodontal surgery","volume":"92","author":"Jepsen","year":"2023","journal-title":"Periodontol. 2000"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/11\/2018\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:24:04Z","timestamp":1760131444000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/11\/2018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,16]]},"references-count":42,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["medicina59112018"],"URL":"https:\/\/doi.org\/10.3390\/medicina59112018","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,16]]}}}