{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T16:59:23Z","timestamp":1793206763770,"version":"4.5.0"},"reference-count":49,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Greifswald"},{"name":"SDI Limited"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: This prospective, comparative, double-cohort study aimed to compare the efficacy of silver diamine fluoride and potassium iodide (38% SDF+KI; Riva Star\u00ae) with sodium fluoride varnish (5% NaF; Duraphat\u00ae) in hypersensitive carious lesions in primary teeth to evaluate caries arrest and hypersensitivity relief. Materials and Methods: This study included thirty 2\u20135-year-olds (mean age = 3.67 \u00b1 1.06 years; 16 males and 14 females) who required a desensitizing treatment for hypersensitive carious defects with visible dentin. A total of 15 of the participants were consecutively allocated to treatment with 5% NaF, and they were further compared to an equal number of participants treated with 38% SDF+KI solutions (n = 15). The treatments were performed following clinical evaluation of caries activity using the International Caries Classification and Management System (ICCMSTM) and the Bj\u00f8rndal criteria (score of 0\u20139). Parental-reported hypersensitivity was evaluated using a visual analogue scale (0\u201310 = no to severe pain). Results: Clinical variables were evaluated at baseline and three months after treatment. Thereafter, a significant decline in hypersensitivity\/pain led to lower final scores in the Riva Star\u00ae group (0.40 \u00b1 1.12, p = 0.002) than in the Duraphat\u00ae group (1.40 \u00b1 2.20, p = 0.004). The caries arrest effect was significantly higher in the Riva Star\u00ae group (86.7%) compared to the Duraphat\u00ae group three months after treatment (13.3%, p &lt; 0.001). In both groups, there were no statistically significant differences in the children\u2019s behavior before, during, and after treatment. Conclusions: Ultimately, with both fluoride therapies reducing hypersensitivity\/pain significantly, treatment with 38% SDF+KI was clearly more effective in caries arrest than 5% NaF varnish after a 3-month period.<\/jats:p>","DOI":"10.3390\/medicina59112042","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T01:54:12Z","timestamp":1700445252000},"page":"2042","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of Different Fluoride Therapies on Hypersensitive Carious Lesions in Primary Teeth"],"prefix":"10.3390","volume":"59","author":[{"given":"Mohamed","family":"Abudrya","sequence":"first","affiliation":[{"name":"Department of Preventive and Pediatric Dentistry, University Medicine of Greifswald, 17475 Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian H.","family":"Splieth","sequence":"additional","affiliation":[{"name":"Department of Preventive and Pediatric Dentistry, University Medicine of Greifswald, 17475 Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mhd Said","family":"Mourad","sequence":"additional","affiliation":[{"name":"Department of Preventive and Pediatric Dentistry, University Medicine of Greifswald, 17475 Greifswald, Germany"},{"name":"Department of Orthodontics, University Medicine of Greifswald, 17475 Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1322-6351","authenticated-orcid":false,"given":"Ruth M.","family":"Santamar\u00eda","sequence":"additional","affiliation":[{"name":"Department of Preventive and Pediatric Dentistry, University Medicine of Greifswald, 17475 Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00784-018-2428-8","article-title":"Fluoride varnish versus glutaraldehyde for hypersensitive teeth: A randomized controlled trial, meta-analysis and trial sequential analysis","volume":"23","author":"Sivaramakrishnan","year":"2019","journal-title":"Clin. 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