{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:45:28Z","timestamp":1789501528760,"version":"build-2803163510"},"reference-count":132,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>In the last few years, vitamin D functions have been studied progressively, and along with their main role in regulating calcium homeostasis, the potential function in the nervous system and the link between different psychiatric disorders and vitamin D deficiency have been revealed. The discovery of vitamin D receptors in multiple brain structures, like the hippocampus, led to the hypothesis that vitamin D deficiency could be responsible for treatment resistance in psychiatric diseases. The aim of this study was to analyze the current knowledge in the literature regarding vitamin D deficiency among individuals afflicted with psychiatric disorders and assess the potential therapeutic benefits of vitamin D supplementation. A systematic search was conducted on the PubMed database for articles published in the last five years (2016\u20132022) in English, focusing on human subjects. Results show that vitamin D deficiency has implications for numerous psychiatric disorders, affecting mood and behavior through its influence on neurotransmitter release, neurotrophic factors, and neuroprotection. It also plays a role in modulating inflammation, which is often elevated in psychiatric disorders. In conclusion, vitamin D deficiency is prevalent and has far-reaching implications for mental health. This review underscores the importance of exploring the therapeutic potential of vitamin D supplementation in individuals with psychiatric disorders and highlights the need for further research in this complex field.<\/jats:p>","DOI":"10.3390\/medicina59122056","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T12:12:13Z","timestamp":1700568733000},"page":"2056","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Severe Vitamin D Deficiency\u2014A Possible Cause of Resistance to Treatment in Psychiatric Pathology"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2520-5486","authenticated-orcid":false,"given":"Adela Magdalena","family":"Ciobanu","sequence":"first","affiliation":[{"name":"Neuroscience Department, Discipline of Psychiatry, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Psychiatry, \u201cProf. Dr. Alexandru Obregia\u201d Clinical Hospital of Psychiatry, 041914 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2295-8976","authenticated-orcid":false,"given":"Cristian","family":"Petrescu","sequence":"additional","affiliation":[{"name":"Neuroscience Department, Discipline of Psychiatry, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Psychiatry, \u201cProf. Dr. Alexandru Obregia\u201d Clinical Hospital of Psychiatry, 041914 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3822-7661","authenticated-orcid":false,"given":"Cristina","family":"Anghele","sequence":"additional","affiliation":[{"name":"Neuroscience Department, Discipline of Psychiatry, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Psychiatry, \u201cProf. Dr. Alexandru Obregia\u201d Clinical Hospital of Psychiatry, 041914 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2492-4529","authenticated-orcid":false,"given":"Mihnea Costin","family":"Manea","sequence":"additional","affiliation":[{"name":"Neuroscience Department, Discipline of Psychiatry, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Psychiatry, \u201cProf. Dr. Alexandru Obregia\u201d Clinical Hospital of Psychiatry, 041914 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0741-6274","authenticated-orcid":false,"given":"Constantin Alexandru","family":"Ciobanu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 020022 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Mihaela","family":"Petrescu","sequence":"additional","affiliation":[{"name":"Department of Neurology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihalache Oana","family":"Antonia","sequence":"additional","affiliation":[{"name":"Neurology Clinic, \u201cFundeni\u201d Clinical Institute, 022328 Bucharest, Romania"},{"name":"Department of Stress Research and Prophylaxis, \u201cProf. Dr. Alexandru Obregia\u201d Clinical Hospital of Psychiatry, 041914 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin","family":"Riga","sequence":"additional","affiliation":[{"name":"Department of Stress Research and Prophylaxis, \u201cProf. Dr. Alexandru Obregia\u201d Clinical Hospital of Psychiatry, 041914 Bucharest, Romania"},{"name":"Romanian Academy of Medical Sciences, 927180 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e210594","DOI":"10.1530\/EC-21-0594","article-title":"100 Years of Vitamin D: Historical aspects of vitamin D","volume":"11","author":"Jones","year":"2022","journal-title":"Endocr. Connect."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D Deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"752","DOI":"10.4065\/mcp.2010.0138","article-title":"Vitamin D Deficiency in Adults: When to Test and How to Treat","volume":"85","author":"Kennel","year":"2010","journal-title":"Mayo Clin. Proc."},{"key":"ref_4","unstructured":"DeLuca, H.F. (1986). Steroid Hormone Resistance: Mechanisms and Clinical Aspects, Springer."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.ecl.2017.07.001","article-title":"Biology and Mechanisms of Action of the Vitamin D Hormone","volume":"46","author":"Pike","year":"2017","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.3390\/nu6114720","article-title":"Serum 25-Hydroxyvitamin D Concentrations and Depressive Symptoms among Young Adult Men and Women","volume":"6","author":"Polak","year":"2014","journal-title":"Nutrients"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1177\/2045125314553612","article-title":"Correlation between total vitamin D levels and psychotic psychopathology in patients with schizophrenia: Therapeutic implications for add-on vitamin D augmentation","volume":"4","author":"Altunsoy","year":"2014","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/MCO.0b013e328010ca18","article-title":"Neurosteroid hormone vitamin D and its utility in clinical nutrition","volume":"10","author":"Kalueff","year":"2007","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jchemneu.2004.08.006","article-title":"Distribution of the Vitamin D receptor and 1\u03b1-hydroxylase in human brain","volume":"29","author":"Eyles","year":"2005","journal-title":"J. Chem. Neuroanat."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1192\/bjp.bp.111.106666","article-title":"Vitamin D deficiency and depression in adults: Systematic review and meta-analysis","volume":"202","author":"Anglin","year":"2013","journal-title":"Br. J. Psychiatry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1016\/j.neubiorev.2012.12.007","article-title":"The neurobiology of depression and antidepressant action","volume":"37","author":"Willner","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.3233\/JAD-132636","article-title":"Vitamin D and Cognition: An Update of the Current Evidence","volume":"42","author":"Anastasiou","year":"2014","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_13","first-page":"118","article-title":"Vitamin D: The \u2018sunshine\u2019 vitamin","volume":"3","author":"Nair","year":"2012","journal-title":"J. Pharmacol. Pharmacother."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.medcli.2019.03.019","article-title":"An epidemiology survey of vitamin D deficiency and its influencing factors","volume":"154","author":"Jiang","year":"2020","journal-title":"Med. Clin."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.2105\/AJPH.2014.302034","article-title":"Meta-analysis of All-Cause Mortality According to Serum 25-Hydroxyvitamin D","volume":"104","author":"Garland","year":"2014","journal-title":"Am. J. Public Health"},{"key":"ref_16","first-page":"21","article-title":"Physician Prescribing Practices of Vitamin D in a Psychiatric Hospital","volume":"13","author":"Mulcahy","year":"2016","journal-title":"Innov. Clin. Neurosci."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Buscemi, S., Buscemi, C., Corleo, D., De Pergola, G., Caldarella, R., Meli, F., Randazzo, C., Milazzo, S., Barile, A.M., and Rosafio, G. (2021). Obesity and Circulating Levels of Vitamin D before and after Weight Loss Induced by a Very Low-Calorie Ketogenic Diet. Nutrients, 13.","DOI":"10.3390\/nu13061829"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Farhangi, M.A., Mesgari-Abbasi, M., Nameni, G., Hajiluian, G., and Shahabi, P. (2017). The effects of vitamin D administration on brain inflammatory markers in high fat diet induced obese rats. BMC Neurosci., 18.","DOI":"10.1186\/s12868-017-0400-1"},{"key":"ref_21","first-page":"S333","article-title":"Vitamin D, Neurosteroids and Autism","volume":"66","author":"Hill","year":"2017","journal-title":"Physiol. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s00421-012-2582-7","article-title":"Circulating pro-inflammatory cytokines are elevated and peak power output correlates with 25-hydroxyvitamin D in vitamin D insufficient adults","volume":"113","author":"Barker","year":"2013","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.tins.2019.01.003","article-title":"Vitamin D in Synaptic Plasticity, Cognitive Function, and Neuropsychiatric Illness","volume":"42","author":"Mayne","year":"2019","journal-title":"Trends Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.encep.2019.02.005","article-title":"Vitamin D deficiency in a psychiatric population and correlation between vitamin D and CRP","volume":"45","author":"Faivre","year":"2019","journal-title":"Encephale"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3389\/fpsyt.2019.00167","article-title":"Prevalence and Correlates of Vitamin D Deficiency in a Sample of 290 Inpatients with Mental Illness","volume":"10","author":"Cuomo","year":"2019","journal-title":"Front. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.psychres.2019.02.060","article-title":"Vitamin D status and correlates of low vitamin D in schizophrenia, other psychoses and non-psychotic depression\u2013The Northern Finland Birth Cohort 1966 study","volume":"279","author":"Ikonen","year":"2019","journal-title":"Psychiatry Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s11126-020-09720-x","article-title":"Patterns of Vitamin D Deficiency in a Community Outpatient Psychiatric Practice: A Real-World Evaluation of Treatment Gaps","volume":"91","author":"Jegede","year":"2020","journal-title":"Psychiatr. Q."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1177\/1039856217726717","article-title":"To screen or not to screen? Vitamin D deficiency in chronic mental illness","volume":"26","author":"Goluza","year":"2018","journal-title":"Australas. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e12390","DOI":"10.1111\/appy.12390","article-title":"Vitamin D deficiency in long-term hospitalization psychiatric wards in an equatorial nation","volume":"12","author":"Suri","year":"2020","journal-title":"Asia-Pac. Psychiatry"},{"key":"ref_30","first-page":"40","article-title":"Vitamin D Status in Patients with Mental Disorders: A Cross-Sectional Analysis of Single Cohort from Routine Practice","volume":"13","author":"Ristic","year":"2017","journal-title":"Acta Endocrinol."},{"key":"ref_31","first-page":"221","article-title":"Serum Vitamin D and Magnesium levels in a psychiatric cohort","volume":"31","author":"Woodward","year":"2019","journal-title":"Psychiatr. Danub."},{"key":"ref_32","first-page":"e3155","article-title":"Relationship between vitamin D deficiency and psychophysiological variables: A systematic review of the literature","volume":"76","author":"Silva","year":"2021","journal-title":"Clinics"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.clnesp.2017.11.011","article-title":"Association between mental disorders, cognitive disturbances and vitamin D serum level: Current state","volume":"23","author":"Lerner","year":"2017","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Jamilian, H., Amirani, E., Milajerdi, A., Kolahdooz, F., Mirzaei, H., Zaroudi, M., Ghaderi, A., and Asemi, Z. (2019). The effects of vitamin D supplementation on mental health, and biomarkers of inflammation and oxidative stress in patients with psychiatric disorders: A systematic review and meta-analysis of randomized controlled trials. Prog. Neuropsychopharmacol. Biol. Psychiatry, 94.","DOI":"10.1016\/j.pnpbp.2019.109651"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Terock, J., Hannemann, A., Van der Auwera, S., Janowitz, D., Spitzer, C., Bonk, S., V\u00f6lzke, H., and Grabe, H.J. (2020). Posttraumatic stress disorder is associated with reduced vitamin D levels and functional polymorphisms of the vitamin D binding-protein in a population-based sample. Prog. Neuropsychopharmacol. Biol. Psychiatry, 96.","DOI":"10.1016\/j.pnpbp.2019.109760"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/1744629516649124","article-title":"Vitamin D deficiency in an inpatient forensic intellectual disability service","volume":"21","author":"Chester","year":"2017","journal-title":"J. Intellect. Disabil."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1192\/bjb.2017.8","article-title":"Vitamin D in patients with intellectual and developmental disability in secure in-patient services in the North of England, UK","volume":"42","author":"McKinnon","year":"2018","journal-title":"BJPsych Bull."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1002\/aur.2424","article-title":"Maternal Vitamin D Levels During Pregnancy in Association With Autism Spectrum Disorders (ASD)or Intellectual Disability (ID) in Offspring; Exploring Non-linear Patterns and Demographic Sub-groups","volume":"13","author":"Windham","year":"2020","journal-title":"Autism Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/aur.2092","article-title":"Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability: A case\u2013control study in California","volume":"12","author":"Windham","year":"2019","journal-title":"Autism Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"S619","DOI":"10.1016\/j.cca.2019.03.1296","article-title":"Vitamin d status in TUNISIAN children with autism spectrum disorders","volume":"493","author":"Chtourou","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jsbmb.2018.10.017","article-title":"A randomised controlled trial of vitamin D and omega-3 long chain polyunsaturated fatty acids in the treatment of irritability and hyperactivity among children with autism spectrum disorder","volume":"187","author":"Mazahery","year":"2019","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s12402-018-0276-7","article-title":"Vitamin D levels in children and adolescents with attention-deficit hyperactivity disorder (ADHD): A meta-analysis","volume":"11","author":"Kotsi","year":"2019","journal-title":"ADHD Atten. Deficit Hyperact. Disord."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Hemamy, M., Pahlavani, N., Amanollahi, A., Islam, S.M.S., McVicar, J., Askari, G., and Malekahmadi, M. (2021). The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: A randomized controlled trial. BMC Pediatr., 21.","DOI":"10.1186\/s12887-021-02631-1"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e1760","DOI":"10.1002\/brb3.1760","article-title":"Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency","volume":"10","author":"Zhu","year":"2020","journal-title":"Brain Behav."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1038\/s41380-021-01025-0","article-title":"Vitamin D and schizophrenia: 20 years on","volume":"26","author":"Cui","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.psychres.2016.12.052","article-title":"Correlates of vitamin D in psychotic disorders: A comprehensive systematic review","volume":"249","author":"Adamson","year":"2017","journal-title":"Psychiatry Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/NMD.0000000000000670","article-title":"Association Between Vitamin D Status and Schizophrenia","volume":"205","author":"Salavert","year":"2017","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Roy, N.M. (2021). Impact of vitamin D on neurocognitive function in dementia, depression, schizophrenia and ADHD. Front. Biosci., 26.","DOI":"10.2741\/4908"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1017\/S0033291719001739","article-title":"Vitamin D concentration and psychotic disorder: Associations with disease status, clinical variables and urbanicity","volume":"50","author":"Stellinga","year":"2020","journal-title":"Psychol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ebiom.2017.11.027","article-title":"Vitamin D Supplementation in Chronic Schizophrenia Patients Treated with Clozapine: A Randomized, Double-Blind, Placebo-controlled Clinical Trial","volume":"26","author":"Krivoy","year":"2017","journal-title":"EBioMedicine"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Neriman, A., Hakan, Y., and Ozge, U. (2021). The psychotropic effect of vitamin D supplementation on schizophrenia symptoms. BMC Psychiatry, 21.","DOI":"10.1186\/s12888-021-03308-w"},{"key":"ref_52","first-page":"941","article-title":"Effectiveness of Vitamin D Supplement Therapy in Chronic Stable Schizophrenic Male Patients: A Randomized Controlled Trial","volume":"15","author":"Sheikhmoonesi","year":"2016","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/08039488.2018.1424238","article-title":"Exploring the relationship between vitamin D and mania: Correlations between serum vitamin D levels and disease activity","volume":"72","author":"Altunsoy","year":"2018","journal-title":"Nord. J. Psychiatry"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/0706743719870513","article-title":"Vuln\u00e9rabilit\u00e9 au Trouble Bipolaire: La Piste de la Vitamine D","volume":"65","author":"Naifar","year":"2020","journal-title":"Can. J. Psychiatry"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jpsychires.2017.07.021","article-title":"Vitamin D supplementation in bipolar depression: A double blind placebo controlled trial","volume":"95","author":"Marsh","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/S0140-6736(17)32802-7","article-title":"Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: A systematic review and network meta-analysis","volume":"391","author":"Cipriani","year":"2018","journal-title":"Lancet"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1176\/ajp.2006.163.11.1905","article-title":"Acute and Longer-Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report","volume":"163","author":"Rush","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1080\/1028415X.2020.1843892","article-title":"Associations of major depressive disorder and related clinical characteristics with 25-hydroxyvitamin D levels in middle-aged adults","volume":"25","author":"Herrmann","year":"2022","journal-title":"Nutr. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1471-4159.2005.03579.x","article-title":"Cross-talk of vitamin D and glucocorticoids in hippocampal cells","volume":"96","author":"Obradovic","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12263-018-0605-7","article-title":"Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neuronal cell lines","volume":"13","author":"Sabir","year":"2018","journal-title":"Genes. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.bbr.2018.08.020","article-title":"Mesolimbic dopamine system and its modulation by vitamin D in a chronic mild stress model of depression in the rat","volume":"356","author":"Sedaghat","year":"2019","journal-title":"Behav. Brain Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2567.2011.03482.x","article-title":"Vitamin D3: A helpful immuno-modulator","volume":"134","author":"Malaguarnera","year":"2011","journal-title":"Immunology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jad.2020.03.029","article-title":"Effects of vitamin D supplementation on depression and some involved neurotransmitters","volume":"269","author":"Kaviani","year":"2020","journal-title":"J. Affect. Disord."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"102732","DOI":"10.1016\/j.msard.2020.102732","article-title":"Serum vitamin d inversely correlates with depression scores in people with multiple sclerosis","volume":"48","author":"Khalil","year":"2021","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/j.clnu.2018.09.011","article-title":"Effect of vitamin D supplementation on depression in elderly patients: A randomized clinical trial","volume":"38","author":"Alavi","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/bmjspcare-2020-002457","article-title":"Prognosis in metastatic lung cancer: Vitamin D deficiency and depression\u2014A cross-sectional analysis","volume":"12","author":"McFarland","year":"2022","journal-title":"BMJ Support. Palliat. Care"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neulet.2018.09.046","article-title":"Vitamin D status and its association with season, depression in stroke","volume":"690","author":"Gu","year":"2019","journal-title":"Neurosci. Lett."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1651-2227.2012.02655.x","article-title":"Depressed adolescents in a case-series were low in vitamin D and depression was ameliorated by vitamin D supplementation","volume":"101","author":"Gustafsson","year":"2012","journal-title":"Acta Paediatr."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Hansen, J.P., Pareek, M., Hvolby, A., Schmedes, A., Toft, T., Dahl, E., and Nielsen, C.T. (2019). Vitamin D3 supplementation and treatment outcomes in patients with depression (D3-vit-dep). BMC Res. Notes, 12.","DOI":"10.1186\/s13104-019-4218-z"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3389\/fpsyt.2019.00322","article-title":"The Relationship Between Serum Concentration of Vitamin D, Total Intracranial Volume, and Severity of Depressive Symptoms in Patients with Major Deprewithe Disorder","volume":"10","author":"Zhu","year":"2019","journal-title":"Front. Psychiatry"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/PSY.0000000000000044","article-title":"Vitamin D Supplementation for Depressive Symptoms","volume":"76","author":"Shaffer","year":"2014","journal-title":"Psychosom. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1142035","DOI":"10.3389\/fnut.2023.1142035","article-title":"Association of a low vitamin D status with risk of post-stroke depression: A meta-analysis and systematic review","volume":"10","author":"Hung","year":"2023","journal-title":"Front. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1007\/s11011-019-00486-1","article-title":"Vitamin D supplementation ameliorates severity of generalized anxiety disorder (GAD)","volume":"34","author":"Eid","year":"2019","journal-title":"Metab. Brain Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s40263-019-00640-4","article-title":"Potential Role of Vitamin D for the Management of Depression and Anxiety","volume":"33","author":"GCasseb","year":"2019","journal-title":"CNS Drugs"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jpsychores.2017.04.005","article-title":"The relationship between serum 25(OH)D levels and anxiety symptoms in older persons: Results from the Longitudinal Aging Study Amsterdam","volume":"97","author":"Verweij","year":"2017","journal-title":"J. Psychosom. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1124\/pr.116.013227","article-title":"Vitamin D and Depression: Cellular and Regulatory Mechanisms","volume":"69","author":"Berridge","year":"2017","journal-title":"Pharmacol. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.psychres.2017.04.032","article-title":"Vitamin B12, folic acid, homocysteine and vitamin D levels in children and adolescents with obsessive compulsive disorder","volume":"254","author":"Yaman","year":"2017","journal-title":"Psychiatry Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"33","DOI":"10.5152\/npa.2015.8763","article-title":"Vitamin D Deficiency in Obsessive\u2013Compulsive Disorder Patients with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections: A Case Control Study","volume":"53","author":"Celik","year":"2016","journal-title":"Noro Psikiyatr. Ars."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/08039488.2017.1406985","article-title":"Vitamin D levels in children and adolescents with obsessive compulsive disorder","volume":"72","author":"Yazici","year":"2018","journal-title":"Nord. J. Psychiatry"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/ped.12941","article-title":"Avci. Vitamin D insufficiency in a boy with obsessive\u2013compulsive disorder","volume":"58","author":"Celik","year":"2016","journal-title":"Pediatr. Int."},{"key":"ref_81","first-page":"22","article-title":"Comorbidity of psychiatric disorders and posttraumatic stress disorder","volume":"61","author":"Brady","year":"2000","journal-title":"J. Clin. Psychiatry"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.psychres.2015.05.036","article-title":"Neuroinflammatory pathways in anxiety, posttraumatic stress, and obsessive compulsive disorders","volume":"229","author":"Furtado","year":"2015","journal-title":"Psychiatry Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1096\/fj.14-269811","article-title":"1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: Implication for behavioral influences of vitamin D","volume":"29","author":"Kaneko","year":"2015","journal-title":"FASEB J."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Hansen, A.L., Ambroziak, G., Thornton, D., Mundt, J.C., Kahn, R.E., Dahl, L., Waage, L., Kattenbraker, D., Araujo, P., and Murison, R. (2020). Vitamin D Supplementation during Winter: Effects on Stress Resilience in a Randomized Control Trial. Nutrients, 12.","DOI":"10.3390\/nu12113258"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/eat.22370","article-title":"Vitamin D status in anorexia nervosa: A meta-analysis","volume":"48","author":"Veronese","year":"2015","journal-title":"Int. J. Eat. Disord."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Hanachi, M., Dicembre, M., Rives-Lange, C., Ropers, J., Bemer, P., Zazzo, J.-F., Poupon, J., Dauvergne, A., and Melchior, J.-C. (2019). Micronutrients Deficiencies in 374 Severely Malnourished Anorexia Nervosa Inpatients. Nutrients, 11.","DOI":"10.3390\/nu11040792"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"8046479","DOI":"10.1155\/2016\/8046479","article-title":"Hypovitaminosis D3, Leukopenia, and Human Serotonin Transporter Polymorphism in Anorexia Nervosa and Bulimia Nervosa","volume":"2016","author":"Tasegian","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/eat.22347","article-title":"High prevalence of vitamin D deficiency and insufficiency in adolescent inpatients diagnosed with eating disorders","volume":"48","author":"Kochavi","year":"2015","journal-title":"Int. J. Eat. Disord."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.eatbeh.2013.01.010","article-title":"Vitamin D, bone mineral density and body mass index in eating disorder patients","volume":"14","author":"Velickovic","year":"2013","journal-title":"Eat. Behav."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1210\/jc.2004-1496","article-title":"Human Bladder as a Novel Target for Vitamin D Receptor Ligands","volume":"90","author":"Crescioli","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/ejcn.2016.20","article-title":"Vitamin D and incident urinary incontinence in older adults","volume":"70","author":"Vaughan","year":"2016","journal-title":"Eur. J. Clin. NutR"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF00496810","article-title":"1,25(OH)2 vitamin D3 sites of action in the brain","volume":"87","author":"Stumpf","year":"1987","journal-title":"Histochemistry"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1016\/j.ijcard.2013.07.195","article-title":"Low vitamin D levels in adults with longer time to fall asleep: US NHANES, 2005\u20132006","volume":"168","author":"Shiue","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.5664\/jcsm.8390","article-title":"Impacts of serum vitamin D levels on sleep and daytime sleepiness according to working conditions","volume":"16","author":"Lee","year":"2020","journal-title":"J. Clin. Sleep. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.5664\/jcsm.8440","article-title":"Vitamin D and sleep in children","volume":"16","author":"Ehsan","year":"2020","journal-title":"J. Clin. Sleep. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"693","DOI":"10.5664\/jcsm.2266","article-title":"Vitamin D, Race, and Excessive Daytime Sleepiness","volume":"8","author":"McCarty","year":"2012","journal-title":"J. Clin. Sleep. Med."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Carlander, B., Puech-Cathala, A.M., Jaussent, I., Scholz, S., Bayard, S., Cochen, V., and Dauvilliers, Y. (2011). Low Vitamin D in Narcolepsy with Cataplexy. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0020433"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cca.2017.10.024","article-title":"Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2 months","volume":"475","author":"Zhao","year":"2017","journal-title":"Clin. Chim. Acta"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s11325-020-02142-w","article-title":"Vitamin D deficiency in patients evaluated for obstructive sleep apnea: Is it associated with disease severity?","volume":"25","author":"Bouloukaki","year":"2021","journal-title":"Sleep Breath."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.sleep.2013.12.009","article-title":"Vitamin D levels and obstructive sleep apnoea in children","volume":"15","author":"Peris","year":"2014","journal-title":"Sleep Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ando.2019.09.004","article-title":"Independent association of vitamin D and insulin resistance in obstructive sleep apnea","volume":"80","author":"Fan","year":"2019","journal-title":"Ann. Endocrinol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"293","DOI":"10.5665\/sleep.5430","article-title":"Serum Vitamin D Is Significantly Inversely Associated with Disease Severity in Caucasian Adults with Obstructive Sleep Apnea Syndrome","volume":"39","author":"Kerley","year":"2016","journal-title":"Sleep"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.sleep.2016.08.022","article-title":"Vitamin D status of male OSAS patients improved after long-term CPAP treatment mainly in obese subjects","volume":"29","author":"Liguori","year":"2017","journal-title":"Sleep Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/13685538.2016.1271783","article-title":"Vitamin D treatment improves levels of sexual hormones, metabolic parameters and erectile function in middle-aged vitamin D deficient men","volume":"20","author":"Canguven","year":"2017","journal-title":"Aging Male"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.juro.2018.10.019","article-title":"Effect of Vitamin D Therapy on Sexual Function in Women with Sexual Dysfunction and Vitamin D Deficiency: A Randomized, Double-Blind, Placebo Controlled Clinical Trial","volume":"201","author":"Gholamrezaei","year":"2019","journal-title":"J. Urol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41443-018-0041-7","article-title":"The effect of low vitamin D status on sexual functioning and depressive symptoms in apparently healthy men: A pilot study","volume":"30","author":"Krysiak","year":"2018","journal-title":"Int. J. Impot. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.atherosclerosis.2016.07.921","article-title":"Vitamin D deficiency is independently associated with greater prevalence of erectile dysfunction: The National Health and Nutrition Examination Survey (NHANES) 2001\u20132004","volume":"252","author":"Farag","year":"2016","journal-title":"Atherosclerosis"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Crafa, A., Cannarella, R., Condorelli, R.A., La Vignera, S., and Calogero, A.E. (2020). Is There an Association Between Vitamin D Deficiency and Erectile Dysfunction? A Systematic Review and Meta-Analysis. Nutrients, 12.","DOI":"10.3390\/nu12051411"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1007\/s40263-021-00876-z","article-title":"Vitamin D Supplementation and Cognition in Adults: A Systematic Review of Randomized Controlled Trials","volume":"35","author":"Beauchet","year":"2021","journal-title":"CNS Drugs"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Bivona, G., Lo Sasso, B., Gambino, C.M., Giglio, R.V., Scazzone, C., Agnello, L., and Ciaccio, M. (2021). The Role of Vitamin D as a Biomarker in Alzheimer\u2019s Disease. Brain Sci., 11.","DOI":"10.3390\/brainsci11030334"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3233\/JAD-150943","article-title":"Vitamin D, Cognition and Alzheimer\u2019s Disease: The Therapeutic Benefit is in the D-Tails","volume":"53","author":"Landel","year":"2016","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/jhn.12636","article-title":"Association of vitamin D and vitamin B12 with cognitive impairment in elderly aged 80 years or older: A cross-sectional study","volume":"32","author":"Beck","year":"2019","journal-title":"J. Hum. Human. Nutr. Diet."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"6097820","DOI":"10.1155\/2020\/6097820","article-title":"Low Vitamin D and Its Association with Cognitive Impairment and Dementia","volume":"2020","author":"Sultan","year":"2020","journal-title":"J. Aging Res."},{"key":"ref_114","first-page":"43","article-title":"Vitamin D and Dementia","volume":"3","author":"Littlejohns","year":"2015","journal-title":"J. Prev. Alzheimers Dis."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1017\/S0029665117004153","article-title":"Is there a role for vitamin D in supporting cognitive function as we age?","volume":"77","author":"Aspell","year":"2018","journal-title":"Proc. Nutr. Soc."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/hbm.24380","article-title":"Vitamin D deficiency is associated with reduced hippocampal volume and disrupted structural connectivity in patients with mild cognitive impairment","volume":"40","author":"Bradford","year":"2019","journal-title":"Hum. Brain Mapp."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.3233\/JAD-200926","article-title":"Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial","volume":"78","author":"Yang","year":"2020","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3233\/JAD-150811","article-title":"Vitamin D and Memory Decline: Two Population-Based Prospective Studies","volume":"50","author":"Soni","year":"2016","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_119","first-page":"34","article-title":"Vitamin D and Delirium in Older Adults: A Case-Control Study in Geriatric Acute Care Unit","volume":"11","author":"Sacco","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"23253","DOI":"10.1038\/s41598-021-02485-8","article-title":"Effect of vitamin D on cognitive decline: Results from two ancillary studies of the VITAL randomized trial","volume":"11","author":"Kang","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"G\u0142\u0105bska, D., Guzek, D., Groele, B., and Gutkowska, K. (2020). Fruit and Vegetable Intake and Mental Health in Adults: A Systematic Review. Nutrients, 12.","DOI":"10.3390\/nu12010115"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Gim\u00e9nez-Meseguer, J., Tortosa-Mart\u00ednez, J., and Cortell-Tormo, J. (2020). The Benefits of Physical Exercise on Mental Disorders and Quality of Life in Substance Use Disorders Patients. Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17103680"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"903547","DOI":"10.3389\/fpubh.2022.903547","article-title":"Effect of vitamin D supplementation on the incidence and prognosis of depression: An updated meta-analysis based on randomized controlled trials","volume":"10","author":"Xie","year":"2022","journal-title":"Front. Public Health"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3109\/01612840903437657","article-title":"Vitamin D and Depression: Where is all the Sunshine?","volume":"31","author":"Penckofer","year":"2010","journal-title":"Issues Ment. Health Nurs."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Carbone, E.A., Menculini, G., de Filippis, R., D\u2019Angelo, M., De Fazio, P., Tortorella, A., and Steardo, L. (2023). Sleep Disturbances in Generalized Anxiety Disorder: The Role of Calcium Homeostasis Imbalance. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20054431"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1096\/fj.14-268342","article-title":"Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: Relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior","volume":"29","author":"Patrick","year":"2015","journal-title":"FASEB J."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e12806","DOI":"10.1111\/cpr.12806","article-title":"Potential role of insulin on the pathogenesis of depression","volume":"53","author":"Zou","year":"2020","journal-title":"Cell Prolif."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0169-328X(96)00260-4","article-title":"1,25-Dihydroxyvitamin D3 inhibits the expression of inducible nitric oxide synthase in rat central nervous system during experimental allergic encephalomyelitis","volume":"45","author":"Garcion","year":"1997","journal-title":"Mol. Brain Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1007\/s10072-012-1268-6","article-title":"Vitamin D inquiry in hippocampal neurons: Consequences of vitamin D-VDR pathway disruption on calcium channel and the vitamin D requirement","volume":"34","author":"Dursun","year":"2013","journal-title":"Neurol. Sci."},{"key":"ref_130","first-page":"88","article-title":"Low serum vitamin D concentrations in patients with schizophrenia","volume":"14","author":"Itzhaky","year":"2012","journal-title":"Isr. Med. Assoc. J."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3109\/13651501.2012.667111","article-title":"Vitamin D, parathyroid hormone, serum calcium and phosphorus in patients with schizophrenia and major depression","volume":"17","author":"Jamilian","year":"2013","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Mikola, T., Marx, W., Lane, M.M., Hockey, M., Loughman, A., Rajapolvi, S., Rocks, T., O\u2019Neil, A., Mischoulon, D., and Valkonen-Korhonen, M. (2022). The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta-analysis of randomized controlled trials. Crit. Rev. Food Sci. 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