{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:12:03Z","timestamp":1793995923614,"version":"4.8.0"},"reference-count":75,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Knee osteoarthritis (OA) is a widespread joint disease, set to increase due to aging and rising obesity. Beyond cartilage degeneration, OA involves the entire joint, including the synovial fluid, bones, and surrounding muscles. Existing treatments, such as NSAIDs and corticosteroid injections, mainly alleviate symptoms but can have complications. Joint replacement surgeries are definitive but carry surgical risks and are not suitable for all. Stromal vascular fraction (SVF) therapy is a regenerative approach using cells from a patient\u2019s adipose tissue. SVF addresses as degenerative and inflammatory aspects, with potential for cartilage formation and tissue regeneration. Unlike traditional treatments, SVF may reverse OA changes. Being autologous, it reduces immunogenic risks. Materials and Methods: A systematic search was undertaken across PubMed, Medline, and Scopus for relevant studies published from 2017 to 2023. Keywords included \u201cSVF\u201d, \u201cKnee Osteoarthritis\u201d, and \u201cRegenerative Medicine\u201d. Results: This systematic search yielded a total of 172 articles. After the removal of duplicates and an initial title and abstract screening, 94 full-text articles were assessed for eligibility. Of these, 22 studies met the inclusion criteria and were subsequently included in this review. Conclusions: This review of SVF therapy for knee OA suggests its potential therapeutic benefits. Most studies confirmed its safety and efficacy, and showed improved clinical outcomes and minimal adverse events. However, differences in study designs and sizes require a careful interpretation of the results. While evidence supports SVF\u2019s positive effects, understanding methodological limitations is key. Incorporating SVF is promising, but the approach should prioritize patient safety and rigorous research.<\/jats:p>","DOI":"10.3390\/medicina59122090","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T06:45:35Z","timestamp":1701153935000},"page":"2090","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Stromal Vascular Fraction Therapy for Knee Osteoarthritis: A Systematic Review"],"prefix":"10.3390","volume":"59","author":[{"given":"Evgeniy Nikolaevich","family":"Goncharov","sequence":"first","affiliation":[{"name":"Petrovsky Russian Scientific Center of Surgery, 121359 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg Aleksandrovich","family":"Koval","sequence":"additional","affiliation":[{"name":"Petrovsky Russian Scientific Center of Surgery, 121359 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Nikolaevich Bezuglov","sequence":"additional","affiliation":[{"name":"Petrovsky Russian Scientific Center of Surgery, 121359 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-0635","authenticated-orcid":false,"given":"Manuel de Jesus","family":"Encarnacion Ramirez","sequence":"additional","affiliation":[{"name":"Department of Neurological Diseases and Neurosurgery, Peoples\u2019 Friendship University of Russia, 121359 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Engelgard","sequence":"additional","affiliation":[{"name":"Petrovsky Russian Scientific Center of Surgery, 121359 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eremin Ilya","family":"Igorevich","sequence":"additional","affiliation":[{"name":"Petrovsky Russian Scientific Center of Surgery, 121359 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Saporiti","sequence":"additional","affiliation":[{"name":"Department of Pharmaceuticals, Azienda Usl Toscana Nord Ovest, 56100 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Valentinovich Kotenko","sequence":"additional","affiliation":[{"name":"Petrovsky Russian Scientific Center of Surgery, 121359 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3686-8907","authenticated-orcid":false,"given":"Nicola","family":"Montemurro","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Azienda Ospedaliero Universitaria Pisana (AOUP), 56100 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"ref_1","first-page":"152","article-title":"The epidemiology, etiology, diagnosis, and treatment of osteoarthritis of the knee","volume":"107","author":"Michael","year":"2010","journal-title":"Dtsch Arztebl Int."},{"key":"ref_2","first-page":"127","article-title":"Non-surgical treatment of knee osteoarthritis","volume":"25","author":"Kan","year":"2019","journal-title":"Hong Kong Med. 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