{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:50:39Z","timestamp":1792713039865,"version":"4.5.0"},"reference-count":61,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Therapeutic plasma exchange (TPE) is a treatment paradigm used to remove harmful molecules from the body. In short, it is a technique that employs a process that functions partially outside the body and involves the replacement of the patient\u2019s plasma. It has been used in the ICU for a number of different disease states, for some as a first-line treatment modality and for others as a type of salvage therapy. This paper provides a brief review of the principles, current applications, and potential future directions of TPE in critical care settings.<\/jats:p>","DOI":"10.3390\/medicina59122152","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T04:28:31Z","timestamp":1702355311000},"page":"2152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Plasmapheresis in the ICU"],"prefix":"10.3390","volume":"59","author":[{"given":"Guleid","family":"Hussein","sequence":"first","affiliation":[{"name":"Mayo Clinic Health System, Mankato, MN 56001, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8508-9371","authenticated-orcid":false,"given":"Bolun","family":"Liu","sequence":"additional","affiliation":[{"name":"Mayo Clinic Health System, Mankato, MN 56001, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2927-1408","authenticated-orcid":false,"given":"Sumeet K.","family":"Yadav","sequence":"additional","affiliation":[{"name":"Mayo Clinic Health System, Mankato, MN 56001, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Warsame","sequence":"additional","affiliation":[{"name":"Mayo Clinic Health System, Mankato, MN 56001, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4703-9151","authenticated-orcid":false,"given":"Ramsha","family":"Jamil","sequence":"additional","affiliation":[{"name":"Sindh Medical College, Jinnah Sindh Medical University, Karachi 75510, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7105-4266","authenticated-orcid":false,"given":"Salim R.","family":"Surani","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA"},{"name":"Department of Medicine and Pharmacology, Texas A&M University, College Station, TX 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2452-2079","authenticated-orcid":false,"given":"Syed A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Mayo Clinic Health System, Mankato, MN 56001, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s40635-023-00510-w","article-title":"Research priorities for therapeutic plasma exchange in critically ill patients","volume":"11","author":"David","year":"2023","journal-title":"Intensive Care Med. 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