{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:16:57Z","timestamp":1771654617384,"version":"3.50.1"},"reference-count":45,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Breast cancer is often seen as a disease that occurs in women, but it can also appear in men in a very small percentage, below 1%. Men have a minimal amount of breast tissue compared to women, which has the potential to become malignant in a similar way to women, although much less frequently. A patient presented with advanced local invasion due to the low amount of breast tissue, with the tumor quickly invading the adjacent structures. Histopathological and immunohistochemical examinations have an extremely important role in the pathology of breast cancer. Given that male breast cancer is rare and there are not enough surgeons specializing in breast surgery in our country, there is a lack of experience in the management and early diagnosis of this type of cancer, which will be highlighted in this article.<\/jats:p>","DOI":"10.3390\/medicina59122167","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T03:58:02Z","timestamp":1702526282000},"page":"2167","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Aggressive Male Breast Cancer\u2014Clinical and Therapeutic Aspects Correlated with the Histopathological Examination: A Case Report and Literature Review"],"prefix":"10.3390","volume":"59","author":[{"given":"Ana-Maria","family":"Petrescu","sequence":"first","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"},{"name":"3rd General Surgery Clinic, Emergency County Hospital, 200642 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9192-7319","authenticated-orcid":false,"given":"Nicolae-Daniel","family":"Pirici","sequence":"additional","affiliation":[{"name":"Department of Research Methodology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anca-Ileana","family":"Ruxanda","sequence":"additional","affiliation":[{"name":"3rd General Surgery Clinic, Emergency County Hospital, 200642 Craiova, Romania"},{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liviu","family":"Vasile","sequence":"additional","affiliation":[{"name":"3rd General Surgery Clinic, Emergency County Hospital, 200642 Craiova, Romania"},{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mircea","family":"P\u00eer\u0219coveanu","sequence":"additional","affiliation":[{"name":"3rd General Surgery Clinic, Emergency County Hospital, 200642 Craiova, Romania"},{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0218tefan","family":"Paitici","sequence":"additional","affiliation":[{"name":"3rd General Surgery Clinic, Emergency County Hospital, 200642 Craiova, Romania"},{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5447-4936","authenticated-orcid":false,"given":"Gabriel-Sebastian","family":"Petrescu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandru Claudiu","family":"Munteanu","sequence":"additional","affiliation":[{"name":"3rd General Surgery Clinic, Emergency County Hospital, 200642 Craiova, Romania"},{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramona-Andreea","family":"Matei","sequence":"additional","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Dumitrache","sequence":"additional","affiliation":[{"name":"3rd General Surgery Clinic, Emergency County Hospital, 200642 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Donoiu","sequence":"additional","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"},{"name":"3rd General Surgery Clinic, Emergency County Hospital, 200642 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stelian-\u0218tef\u0103ni\u021b\u0103","family":"Mogoant\u0103","sequence":"additional","affiliation":[{"name":"3rd General Surgery Clinic, Emergency County Hospital, 200642 Craiova, Romania"},{"name":"Department of Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1200\/JCO.2009.25.5729","article-title":"Multidisciplinary meeting on male breast can\u2014cer: Summary and research recommendations","volume":"28","author":"Korde","year":"2010","journal-title":"J. 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