{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:34:38Z","timestamp":1792712078273,"version":"4.5.0"},"reference-count":41,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Immunoglobulin G4-related disease (IgG4-RD) is a recently recognized immune-mediated, systemic condition of unknown etiology, associated with fibroinflammatory lesions. Diagnosis is set in the presence of IgG4-positive plasma cell infiltration of the involved tissue and elevated serum IgG4 levels. However, approximately 30% of patients have normal serum IgG4 levels. IgG4-RD may affect several organs, including the pancreas, bile ducts, mesentery, retroperitoneum, and salivary glands, but the involvement of the gastrointestinal tract is uncommon. Materials and Methods: The case series of 4 patients with IgG4-RD involving the intestinal tract was observed in the period of 2017\u20132022. Colorectal and ileal biopsy specimens were stained with hematoxylin and eosin and immunohistochemical techniques using monoclonal antihuman IgG4 primary antibody. Diagnosis of IgG4-RD was based on the presence of &gt;50 cells\/ HPF and IgG4\/IgG ratio &gt;40 confirmed by two pathologists. Results: IgG4-RD was set in patients previously diagnosed as affected by Crohn\u2019s disease. Conclusions: Systematic IgG4 immunohistochemical staining should be considered in the diagnostic workup of patients with gastrointestinal strictures, mimicking Crohn\u2019s disease. The exact prevalence of the condition is likely more frequent than reported and should be defined by a large series of consecutive patients.<\/jats:p>","DOI":"10.3390\/medicina60010057","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T09:56:27Z","timestamp":1703757387000},"page":"57","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Immunoglobulin G4-Related Disease of the Intestine: A Clinicopathological Entity to Be Considered"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1350-4876","authenticated-orcid":false,"given":"Filippo","family":"Vernia","sequence":"first","affiliation":[{"name":"Department of Life, Health, and Environmental Sciences, Division of Gastroenterology, Hepatology, and Nutrition, University of L\u2019Aquila, Piazza S. Tommasi, 1, Coppito, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cirella","sequence":"additional","affiliation":[{"name":"Pathology Unit, San Salvatore Hospital, Via Lorenzo Natali, 1, Coppito, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Calvisi","sequence":"additional","affiliation":[{"name":"Pathology Unit, San Salvatore Hospital, Via Lorenzo Natali, 1, Coppito, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8513-3758","authenticated-orcid":false,"given":"Angelo","family":"Viscido","sequence":"additional","affiliation":[{"name":"Department of Life, Health, and Environmental Sciences, Division of Gastroenterology, Hepatology, and Nutrition, University of L\u2019Aquila, Piazza S. Tommasi, 1, Coppito, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6341-5711","authenticated-orcid":false,"given":"Giovanni","family":"Latella","sequence":"additional","affiliation":[{"name":"Department of Life, Health, and Environmental Sciences, Division of Gastroenterology, Hepatology, and Nutrition, University of L\u2019Aquila, Piazza S. Tommasi, 1, Coppito, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1007\/s10620-018-4950-6","article-title":"IgG4-Related Disease Mimicking Crohn\u2019s Disease: A Case Report and Review of Literature","volume":"63","author":"Ciccone","year":"2018","journal-title":"Dig. Dis. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/PAP.0b013e3181ee63ce","article-title":"IgG4-related sclerosing disease: A critical appraisal of an evolving clinicopathologic entity","volume":"17","author":"Cheuk","year":"2010","journal-title":"Adv. Anat. Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/01.pas.0000213445.08902.11","article-title":"Chronic sclerosing dacryoadenitis: Part of the spectrum of IgG4-related sclerosing disease?","volume":"31","author":"Cheuk","year":"2007","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.autrev.2010.05.003","article-title":"The birthday of a new syndrome: IgG4-related diseases constitute a clinical entity","volume":"9","author":"Takahashi","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"ref_5","first-page":"565","article-title":"IgG4-related disease: A systemic condition with characteristic microscopic features","volume":"28","author":"Detlefsen","year":"2013","journal-title":"Histol. Histopathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1007\/BF02285209","article-title":"Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis","volume":"40","author":"Yoshida","year":"1995","journal-title":"Dig. Dis. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/hep.21697","article-title":"Th2 and regulatory immune reactions are increased in immunoglobulin G4-related sclerosing pancreatitis and cholangitis","volume":"45","author":"Zen","year":"2007","journal-title":"Hepatology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.5858\/2005-129-1148-APMTJA","article-title":"Autoimmune pancreatitis: More than just a pancreatic disease? A contemporary review of its pathology","volume":"129","author":"Deshpande","year":"2005","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1097\/PAS.0b013e318059b87c","article-title":"Pseudotumors due to IgG4 immune-complex tubulointerstitial nephritis associated with auto-immune pancreatitis","volume":"31","author":"Cornell","year":"2007","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/bjd.13296","article-title":"IgG4-related skin disease","volume":"171","author":"Tokura","year":"2014","journal-title":"Br. J. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/jclinpath-2011-200565","article-title":"Chronic gastric ulceration: A novel manifestation of IgG4-related disease?","volume":"65","author":"Bateman","year":"2012","journal-title":"J. Clin. Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.3748\/wjg.v19.i35.5769","article-title":"Immunoglobulin G4-related gastrointestinal diseases, are they immunoglobulin G4-related diseases?","volume":"19","author":"Koizumi","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/annrheumdis-2013-204907","article-title":"The diagnostic utility of serum IgG4 concentrations in IgG4related disease","volume":"74","author":"Carruthers","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41575-021-00529-y","article-title":"IgG4-relateddiseases of the digestive tract","volume":"19","author":"Vujasinovic","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/modpathol.2012.72","article-title":"Consensus statement on the pathology of IgG4-related disease","volume":"25","author":"Deshpande","year":"2012","journal-title":"Mod. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1177\/2050640620934911","article-title":"European Guideline on IgG4-related digestive disease\u2014UEG and SGF evidence-based recommendations","volume":"8","author":"Beuers","year":"2020","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1002\/art.39205","article-title":"IgG4-related disease. Clinical and laboratory features in one hundred twenty-five patients","volume":"67","author":"Wallace","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.3748\/wjg.v28.i36.5300","article-title":"Histopathological assessment of the microscopic activity in inflammatory bowel diseases: What are we looking for?","volume":"28","author":"Fabian","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"E163","DOI":"10.1055\/a-1952-0490","article-title":"Multifocal ulcerating stenosing enteritis as a novel manifestation of immunoglobulin G4-related disease","volume":"55","year":"2023","journal-title":"Endoscopy"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"816830","DOI":"10.3389\/fimmu.2022.816830","article-title":"IgG4-Related Disease With Gastrointestinal Involvement: Case Reports and Literature Review","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1007\/s10620-010-1287-1","article-title":"IgG4-related sclerosing disease: A novel mimic of inflammatory bowel disease","volume":"55","author":"Narula","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1007\/s10620-012-2267-4","article-title":"Histologically confirmed IgG4-related small intestinal lesions diagnosed via double balloon enteroscopy","volume":"57","author":"Fujita","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s40792-016-0248-0","article-title":"IgG4-related sclerosing mesenteritis causing bowel obstruction: A case report","volume":"2","author":"Abe","year":"2016","journal-title":"Surg. Case Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4166\/kjg.2023.056","article-title":"Immunoglobulin G4-related Disease of the Small Bowel: A Case of Long-term Remission Achieved by Surgical Resection without Maintenance Therapy","volume":"82","author":"Kang","year":"2023","journal-title":"Korean J. Gastroenterol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Comprehensive Diagnostic Criteria for IgG4-Related Disease (IgG4-RD) (2012). Research Program of Intractable Disease provided by the Ministry of Health, Labor, and Welfare of Japan. Nihon Naika Gakkai zasshi. J. Jpn. Soc. Intern. Med., 101, 795\u2013804.","DOI":"10.2169\/naika.101.795"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/art.39132","article-title":"International Consensus Guidance Statement on the Management and Treatment of IgG4-Related Disease","volume":"67","author":"Khosroshahi","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/BOR.0b013e3283413469","article-title":"Serologic issues in IgG4-related systemic disease and autoimmune pancreatitis","volume":"23","author":"Sah","year":"2011","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"285","DOI":"10.5114\/ceh.2019.89119","article-title":"IgG4 subclass and gamma-glutamyl transferase in children with ulcerative colitis with primary sclerosing cholangitis and without sclerosing cholangitis","volume":"5","author":"Farahmand","year":"2019","journal-title":"Clin. Exp. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1097\/MIB.0b013e318281344d","article-title":"Mucosal IgG4 Cell Infiltration in Ulcerative Colitis Is Linked to Disease Activity and Primary Sclerosing Cholangitis","volume":"19","author":"Raina","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1177\/10668969231152242","article-title":"High-Density IgG4+ Plasma Cells Infiltration Is Associated with Fibroplasia in Fibrostenotic Crohn\u2019s Disease","volume":"31","author":"Escobar","year":"2023","journal-title":"Int. J. Surg. Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/PAT.0b013e328340e450","article-title":"Sclerosing nodular lesions of the gastrointestinal tract containing large numbers of IgG4 plasma cells","volume":"43","author":"Chetty","year":"2011","journal-title":"Pathology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ijscr.2014.08.003","article-title":"IgG4-related disease of the ileocecal region mimicking malignancy: A case report","volume":"5","author":"Hiyoshi","year":"2014","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/RLU.0000000000002140","article-title":"IgG4-Related Disease Simulating Carcinoma Colon With Diffuse Peritoneal Carcinomatosis on 18F-FDG PET\/CT","volume":"43","author":"Vadi","year":"2018","journal-title":"Clin. Nucl. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1053\/j.gastro.2018.06.082","article-title":"Gastrointestinal and Extra-Intestinal Manifestations of IgG4-Related Disease","volume":"155","author":"Miyabe","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s12328-020-01337-8","article-title":"IgG4-related disease manifesting as symptoms of appendicitis: Case report and literature review","volume":"14","year":"2021","journal-title":"Clin. J. Gastroenterol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1002\/deo2.76","article-title":"Immunoglobulin G4-related disease accompanying a small intestinal ulcer: A case","volume":"2","author":"Yoshidome","year":"2021","journal-title":"DEN Open"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1016\/j.cgh.2020.04.065","article-title":"Immunoglobulin G4-Related Disease Mimicking Malignant Bowel Obstruction","volume":"19","author":"Syu","year":"2021","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3348\/kjr.2016.17.1.56","article-title":"Appendiceal Immunoglobulin G4-Related Disease Mimicking Appendiceal Tumor or Appendicitis: A Case Report","volume":"17","author":"Kim","year":"2016","journal-title":"Korean J. Radiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1097\/PAS.0b013e3182495c96","article-title":"IgG4-related sclerosing disease of the small bowel presenting as necrotizing mesenteric arteritis and a solitary jejunal ulcer","volume":"36","author":"Wong","year":"2012","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"385","DOI":"10.4103\/1319-3767.145333","article-title":"IgG4-related sclerosing mesenteritis in a 7-year-old Saudi girl","volume":"20","author":"Hasosah","year":"2014","journal-title":"Saudi J. Gastroenterol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3348\/kjr.2014.15.1.66","article-title":"Small bowel obstruction caused by peritoneal immunoglobulin G4-related disease mimicking carcinomatosis: Case report","volume":"15","author":"Coulier","year":"2014","journal-title":"Korean J. Radiol."}],"updated-by":[{"DOI":"10.3390\/medicina62030486","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000}}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/1\/57\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T13:12:46Z","timestamp":1772716366000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/1\/57"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,28]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["medicina60010057"],"URL":"https:\/\/doi.org\/10.3390\/medicina60010057","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,28]]}}}