{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:33:54Z","timestamp":1760142834945,"version":"build-2065373602"},"reference-count":49,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Albert Szent-Gy\u00f6rgyi Medical School of the University of Szeged"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Increasing evidence points to the significant role of the angiogenic factor levels in screening for pregnancy outcome. To examine the potential relationship between concentrations of placental protein 13 (PP13) and soluble human leukocyte antigen-G (sHLA-G) in maternal serum and amniotic fluid at 16\u201323 weeks of gestation and the sonographic features of pregnancy as well as pregnancy outcome. Materials and Methods: PP13 and sHLA-G in serum and amniotic fluid, fetal biometrical data, and placental volume and perfusion indices were determined in 71 euploid, singleton pregnancies. Results: The serum sHLA-G level exhibits a negative correlation with the serum PP13 level (r = \u22120.186, p &lt; 0.001) and a positive correlation with the sHLA-G level in amniotic fluid (r = 0.662, p &lt; 0.001). A significant correlation was found between serum sHLA-G level and placental volume (r = 0.142, p &lt; 0.05) and between amniotic sHLA-G level and placental perfusion (r = \u22120.450, p &lt; 0.001). A low amniotic PP13 level significantly predicted the birth weight (r = \u22120.102, p &lt; 0.05), the duration of pregnancy (r = \u22120.155, p &lt; 0.05), and the fetal abdominal circumference (r = \u22120.098, p &lt; 0.05). Conclusions: PP13 assayed in amniotic fluid might be a potential marker of fetal growth, and sHLA-G can be an adjunct modality reflecting placental sonographic parameters.<\/jats:p>","DOI":"10.3390\/medicina60010085","type":"journal-article","created":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T13:02:58Z","timestamp":1704114178000},"page":"85","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictive Capabilities of Human Leukocyte Antigen-G and Galectin-13 Levels in the Amniotic Fluid and Maternal Blood for the Pregnancy Outcome"],"prefix":"10.3390","volume":"60","author":[{"given":"M\u00e1ri\u00f3","family":"Vincze","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Szeged, H-6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"J\u00e1nos","family":"Sikovanyecz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Szeged, H-6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Szeged, H-6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imre","family":"F\u00f6ldesi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of Szeged, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1168-7261","authenticated-orcid":false,"given":"Andrea","family":"Sur\u00e1nyi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Szeged, H-6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szabolcs","family":"V\u00e1rb\u00edr\u00f3","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Szeged, H-6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1829-3457","authenticated-orcid":false,"given":"G\u00e1bor","family":"N\u00e9meth","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Szeged, H-6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"Sikovanyecz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Szeged, H-6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7485-9895","authenticated-orcid":false,"given":"Zoltan","family":"Kozinszky","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Danderyd Hospital, 182 88 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.placenta.2017.01.119","article-title":"Review: Placental derived biomarkers of pregnancy disorders","volume":"54","author":"Cuffe","year":"2017","journal-title":"Placenta"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/micc.12093","article-title":"Regulation of Placental Angiogenesis","volume":"21","author":"Chen","year":"2014","journal-title":"Microcirculation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/molehr\/gah211","article-title":"Human villous trophoblast and the lack of intron 4-retaining soluble HLA-G secretion: Beware of possible methodological biases","volume":"11","year":"2005","journal-title":"Mol. 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