{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:07:19Z","timestamp":1785769639582,"version":"3.56.0"},"reference-count":45,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Hydroxyurea is a crucial treatment for sickle cell disease (SCD), but some patients\u2019 adherence to it remains suboptimal. Understanding patients\u2019 perspectives on SCD and HU is essential for improving adherence. This study aimed to assess hydroxyurea adherence and patients\u2019 perceptions of SCD and hydroxyurea among SCD patients in the Jazan region of Saudi Arabia. Materials and Methods: This cross-sectional study collected data from 217 SCD patients using self-administered questionnaires from August 2022 to January 2023. The survey covered patient demographics, SCD consequences, and other clinical data. We used the Brief Illness Perception Questionnaire (B-IPQ) to measure patients\u2019 disease perception and the 8-item Morisky Medication Adherence Scale (MMAS-8) to evaluate patients\u2019 adherence to HU. Data were analysed using descriptive, t-test, and chi-square tests, and the p-value was set at &lt;0.05 for significance. Results: More than half of the patients were male, with a mean age of 28.09 \u00b1 8.40 years. About 57.6% of the patients were currently using HU. About 81.6% of HU users reported low adherence. The adherence was lower among individuals with infections\/recurrent infections and in patients who received repeated blood transfusions. ICU admission, blood transfusion, and certain SCD complications were associated with HU use. Male patients had a higher perception of SCD consequences, concern, and understanding. ICU-admitted and recurrent hospitalized patients had a higher perception of the SCD-related consequences, symptoms, concerns, and emotional responses. Conclusions: HU seems a well-established and efficacious disease-modifying agent, but its underutilization for SCD patients remains challenging. To overcome the adherence challenges, healthcare providers must educate SCD patients about the role of hydroxyurea in lowering disease severity and addressing side effects to obtain maximum benefits. Healthcare providers may consider tailored educational interventions to improve adherence, particularly for patients with infections, recurrent hospitalizations, or repeated blood transfusions. Further research is needed to identify strategies for improving hydroxyurea adherence and patient education among SCD patients.<\/jats:p>","DOI":"10.3390\/medicina60010124","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T05:47:21Z","timestamp":1704865641000},"page":"124","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Adherence to Hydroxyurea and Patients\u2019 Perceptions of Sickle Cell Disease and Hydroxyurea: A Cross-Sectional Study"],"prefix":"10.3390","volume":"60","author":[{"given":"Mohammed Ali","family":"Madkhali","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology and Oncology, Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7070-4367","authenticated-orcid":false,"given":"Faisal","family":"Abusageah","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6162-3338","authenticated-orcid":false,"given":"Faisal","family":"Hakami","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9141-5583","authenticated-orcid":false,"given":"Basem","family":"Zogel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8462-4421","authenticated-orcid":false,"given":"Khalid M.","family":"Hakami","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Alfaifi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Essam","family":"Alhazmi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaden","family":"Zaalah","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadi","family":"Trabi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4260-6540","authenticated-orcid":false,"given":"Abdulaziz H.","family":"Alhazmi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9353-6520","authenticated-orcid":false,"given":"Mostafa","family":"Mohrag","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7148-9769","authenticated-orcid":false,"given":"Hafiz","family":"Malhan","sequence":"additional","affiliation":[{"name":"Department of Hematology, Prince Mohammed Bin Nasser Hospital, Jazan 82943, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"ref_1","unstructured":"(2023, April 26). 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