{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:30:47Z","timestamp":1777501847445,"version":"3.51.4"},"reference-count":32,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T00:00:00Z","timestamp":1705104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jagiellonian University Medical College","award":["N41\/DBS\/000666"],"award-info":[{"award-number":["N41\/DBS\/000666"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Biochemical and molecular regulation of both adaptive and pathological responses of heart tissue to ischemic injury is widely investigated. However, it is still not fully understood. Several biomarkers are tested as predictors of left ventricle (LV) remodeling after myocardial infarction (MI). The aim of this study was to assess the relationship between selected microRNAs (miRNAs) and LV function and morphology in patients after MI. Materials and Methods: Selected miRNAs related to heart failure were assessed in the acute phase of MI: miR-150-3p, miR-21-5p, miR-19b-3p, miR-155-5p, miR-22-5p. Echocardiography with 3D imaging was performed at baseline and after 6 months. Remodeling was defined as &gt;20% increase in LV end-diastolic volume, whereas reverse remodeling was defined as &gt;10% reduction in LV end-systolic volume. Results: Eighty patients entered the registry. Remodeling occurred in 26% and reverse remodeling was reported in 51% of patients. In the presented study, none of the analyzed miRNAs were found to be a significant LV remodeling predictor. The observed correlations between miRNAs and other circulating biomarkers of myocardial remodeling were relatively weak. Conclusions: Our analysis does not demonstrate an association between the analyzed miRNAs and LV remodeling in patients with MI.<\/jats:p>","DOI":"10.3390\/medicina60010149","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T04:03:26Z","timestamp":1705291406000},"page":"149","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["In-Hospital Levels of Circulating MicroRNAs as Potential Predictors of Left Ventricular Remodeling Post-Myocardial Infarction"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7001-7340","authenticated-orcid":false,"given":"Micha\u0142","family":"W\u0119giel","sequence":"first","affiliation":[{"name":"Clinical Department of Cardiology and Cardiovascular Interventions, University Hospital in Krakow, 30-688 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8396-1488","authenticated-orcid":false,"given":"Marcin","family":"Surmiak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Jagiellonian University Medical College, 30-688 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2189-0498","authenticated-orcid":false,"given":"Krzysztof Piotr","family":"Malinowski","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, 30-688 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2100-5076","authenticated-orcid":false,"given":"Artur","family":"Dziewierz","sequence":"additional","affiliation":[{"name":"Clinical Department of Cardiology and Cardiovascular Interventions, University Hospital in Krakow, 30-688 Krakow, Poland"},{"name":"2nd Department of Cardiology, Institute of Cardiology, Jagiellonian University Medical College, 30-688 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7949-3140","authenticated-orcid":false,"given":"Andrzej","family":"Surdacki","sequence":"additional","affiliation":[{"name":"Clinical Department of Cardiology and Cardiovascular Interventions, University Hospital in Krakow, 30-688 Krakow, Poland"},{"name":"2nd Department of Cardiology, Institute of Cardiology, Jagiellonian University Medical College, 30-688 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4508-3551","authenticated-orcid":false,"given":"Stanis\u0142aw","family":"Bartu\u015b","sequence":"additional","affiliation":[{"name":"Clinical Department of Cardiology and Cardiovascular Interventions, University Hospital in Krakow, 30-688 Krakow, Poland"},{"name":"2nd Department of Cardiology, Institute of Cardiology, Jagiellonian University Medical College, 30-688 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6478-6186","authenticated-orcid":false,"given":"Tomasz","family":"Rakowski","sequence":"additional","affiliation":[{"name":"Clinical Department of Cardiology and Cardiovascular Interventions, University Hospital in Krakow, 30-688 Krakow, Poland"},{"name":"2nd Department of Cardiology, Institute of Cardiology, Jagiellonian University Medical College, 30-688 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.amjmed.2010.07.023","article-title":"Recent trends in the incidence, treatment, and outcomes of patients with STEMI and NSTEMI","volume":"124","author":"McManus","year":"2011","journal-title":"Am. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1161\/01.CIR.101.25.2981","article-title":"Left ventricular remodeling after myocardial infarction: Pathophysiology and therapy","volume":"101","author":"Sutton","year":"2000","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1152\/ajpheart.00131.2018","article-title":"Myocardial infarction remodeling that progresses to heart failure: A signaling misunderstanding","volume":"315","author":"Mouton","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","article-title":"The Biological Basis for Cardiac Repair after Myocardial Infarction, from Inflammation to Fibrosis","volume":"119","author":"Prabhu","year":"2016","journal-title":"Circ Res."},{"key":"ref_5","first-page":"16150","article-title":"Mid-regional pro-adrenomedullin and lactate dehydrogenase as predictors of left ventricular remodeling in patients with myocardial infarction treated with percutaneous coronary intervention","volume":"132","author":"Malinowski","year":"2022","journal-title":"Pol. Arch. Intern. Med."},{"key":"ref_6","first-page":"21","article-title":"Circulating biomarkers as predictors of left ventricular remodeling after myocardial infarction","volume":"17","author":"Rakowski","year":"2021","journal-title":"Adv. Interv. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.amjcard.2012.02.069","article-title":"Usefulness of circulating biomarkers for the prediction of left ventricular remodeling after myocardial infarction","volume":"110","author":"Fertin","year":"2012","journal-title":"Am. J. Cardiol."},{"key":"ref_8","first-page":"217","article-title":"The role of temporal changes of pro-inflammatory cytokines in the development of adverse cardiac remodeling after ST-elevation myocardial infarction","volume":"18","author":"Altintas","year":"2022","journal-title":"Adv. Interv. Cardiol."},{"key":"ref_9","first-page":"356","article-title":"Higher levels of TWEAK and matrix metalloproteinase-3 during the acute phase of myocardial infarction are associated with adverse left ventricular remodeling","volume":"17","author":"Eyyupkoca","year":"2021","journal-title":"Adv. Interv. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1002\/jcp.27486","article-title":"An overview of microRNAs, Biology, functions, therapeutics, and analysis methods","volume":"234","author":"Saliminejad","year":"2019","journal-title":"J. Cell Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"G\u00f3ra, M., Kiliszek, M., Maciak, K., Salamaga, H., \u0141azowski, K., and Burzy\u0144ska, B. (2023). A novel microRNA differentially expressed between persistent and paroxysmal atrial fibrillation patients. Pol. Arch. Intern. Med., 16650.","DOI":"10.20452\/pamw.16650"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Badacz, R., Przew\u0142ocki, T., Legutko, J., \u017bmudka, K., and Kab\u0142ak-Ziembicka, A. (2022). microRNAs Associated with Carotid Plaque Development and Vulnerability, The Clinician\u2019s Perspective. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415645"},{"key":"ref_13","first-page":"59","article-title":"MicroRNAs in the development of left ventricular remodeling and postmyocardial infarction heart failure","volume":"130","author":"Sygitowicz","year":"2020","journal-title":"Pol. Arch. Intern. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5603\/KP.a2014.0210","article-title":"MicroRNAs: Powerful regulators and potential diagnostic tools in cardiovascular disease","volume":"73","author":"Klimczak","year":"2015","journal-title":"Kardiol. Pol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"613","DOI":"10.5603\/KP.a2015.0067","article-title":"Release kinetics of circulating miRNA-208a in the early phase of myocardial infarction","volume":"73","author":"Zajkowska","year":"2015","journal-title":"Kardiol. Pol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults, an Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Leanc\u0103, S.A., Cri\u0219u, D., Petri\u0219, A.O., Afr\u0103s\u00e2nie, I., Genes, A., Costache, A.D., Tesloianu, D.N., and Costache, I.I. (2022). Left Ventricular Remodeling after Myocardial Infarction, from Physiopathology to Treatment. Life, 12.","DOI":"10.3390\/life12081111"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1161\/CIRCRESAHA.121.318172","article-title":"Epidemiology of Heart Failure, a Contemporary Perspective","volume":"128","author":"Roger","year":"2021","journal-title":"Circ. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11886-017-0876-4","article-title":"Adverse Remodeling and Reverse Remodeling after Myocardial Infarction","volume":"19","author":"Bhatt","year":"2017","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ijcard.2016.06.185","article-title":"Advanced research on the microRNA mechanism in heart failure","volume":"220","author":"Deng","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.acvd.2015.07.003","article-title":"Circulating microribonucleic acids miR-1, miR-21 and miR-208a in patients with symptomatic heart failure, Preliminary results","volume":"108","author":"Sygitowicz","year":"2015","journal-title":"Arch. Cardiovasc. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000437090","article-title":"Circulating MicroRNA-146a and MicroRNA-21 Predict Left Ventricular Remodeling after ST-Elevation Myocardial Infarction","volume":"132","author":"Liu","year":"2015","journal-title":"Cardiology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s41419-018-0805-5","article-title":"MicroRNA-21 prevents excessive inflammation and cardiac dysfunction after myocardial infarction through targeting KBTBD7","volume":"9","author":"Yang","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tcm.2014.07.005","article-title":"miR-22 in cardiac remodeling and disease","volume":"24","author":"Huang","year":"2014","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000477235","article-title":"Failed Downregulation of Circulating MicroRNA-155 in the Early Phase after ST Elevation Myocardial Infarction Is Associated with Adverse Left Ventricular Remodeling","volume":"138","author":"Latet","year":"2017","journal-title":"Cardiology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"7287","DOI":"10.3892\/mmr.2017.7584","article-title":"Inhibition of microRNA-155 ameliorates cardiac fibrosis in the process of angiotensin II-induced cardiac remodeling","volume":"16","author":"Wei","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1038\/s41467-019-09530-1","article-title":"Therapeutic role of miR-19a\/19b in cardiac regeneration and protection from myocardial infarction","volume":"10","author":"Gao","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1474-9726.2011.00714.x","article-title":"MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure","volume":"10","author":"Verhesen","year":"2011","journal-title":"Aging Cell."},{"key":"ref_29","first-page":"7611","article-title":"MicroRNA-150 alleviates acute myocardial infarction through regulating cardiac fibroblasts in ventricular remodeling","volume":"23","author":"Tian","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1161\/CIRCGENETICS.113.000077","article-title":"MicroRNA-150: A novel marker of left ventricular remodeling after acute myocardial infarction","volume":"6","author":"Devaux","year":"2013","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/cvr\/cvv121","article-title":"MicroRNA-150 protects the mouse heart from ischaemic injury by regulating cell death","volume":"106","author":"Tang","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.ijcard.2012.12.074","article-title":"Circulating miR-133a and miR-423-5p fail as biomarkers for left ventricular remodeling after myocardial infarction","volume":"168","author":"Bauters","year":"2013","journal-title":"Int. J. Cardiol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/1\/149\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:46:03Z","timestamp":1760103963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/1\/149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,13]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["medicina60010149"],"URL":"https:\/\/doi.org\/10.3390\/medicina60010149","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,13]]}}}