{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T18:22:43Z","timestamp":1773166963740,"version":"3.50.1"},"reference-count":43,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T00:00:00Z","timestamp":1705795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Introduction: Melanoma, a malignant tumor arising from uncontrolled melanocytic proliferation, commonly found in the skin but capable of affecting extracutaneous sites, ranks fifth among diagnosed oncological entities and is a significant cause of cancer deaths, constituting over 80% of skin cancer mortality. Genetic factors and ultraviolet radiation (UVR) exposure, from both natural and artificial sources, are the primary risk factors. Case Presentation: We reported the case of a 25-year-old female with numerous pigmented nevi and notable changes attributed to extensive indoor tanning sessions. Dermatological examinations and dermoscopic evaluations revealed atypical features in two pigmented nevi, leading to surgical excision. Histopathological and immunohistochemical analyses confirmed a compound nevus in one lesion and superficial spreading melanoma in the other, emphasizing the importance of vigilant follow-up and the correct use of immunohistochemistry. Discussion: Indoor tanning significantly elevates the cutaneous melanoma risk, with initiation before age 35 amplifying the risk by up to 75%, especially in young women. The risk escalates with cumulative sessions, particularly exceeding 480, and individuals undergoing over 30 sessions face a 32% higher risk. UVR induces DNA damage, genetic mutations, and immunosuppression, contributing to oncogenesis. Genetic factors, like the PTCHD2 gene, may influence the tanning dependency. Legislation targeting minors has been enacted globally but only with partial efficacy. Tanning accelerators, though associated with minor side effects, correlate with high-risk behaviors. The case underscores the urgency of addressing indoor tanning risks, emphasizing targeted awareness efforts and legislative improvements. Conclusions: In conclusion, the reported case highlights the increased risk of cutaneous melanoma linked to indoor tanning, particularly among young women and specific sociodemographic groups. Despite legislative measures, challenges persist, suggesting the potential efficacy of online campaigns involving relatable influencers to raise awareness and discourage artificial tanning.<\/jats:p>","DOI":"10.3390\/medicina60010187","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T05:42:31Z","timestamp":1705902151000},"page":"187","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Recent-Onset Melanoma and the Implications of the Excessive Use of Tanning Devices\u2014Case Report and Review of the Literature"],"prefix":"10.3390","volume":"60","author":[{"given":"Luana-Andreea","family":"Nurla","sequence":"first","affiliation":[{"name":"Faculty of Medicine, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Dermatology Clinic, \u201cElias\u201d Emergency University Hospital, 011461 Bucharest, Romania"},{"name":"Institute of Doctoral Studies, Doctoral School of Medicine, \u201cOvidius\u201d University of Constanta, 900573 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina","family":"Wafi","sequence":"additional","affiliation":[{"name":"Dermatovenerology Clinic, \u201cVictor Babe\u0219\u201d Clinical Hospital for Infectious and Tropical Diseases, 030303 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4606-4064","authenticated-orcid":false,"given":"Raluca","family":"Tatar","sequence":"additional","affiliation":[{"name":"Department of Plastic Reconstructive Surgery and Burns, \u201cGrigore Alexandrescu\u201d Clinical Emergency Hospital for Children, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7752-7930","authenticated-orcid":false,"given":"Alexandra Maria","family":"Doroban\u021bu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Dermatology Clinic, \u201cElias\u201d Emergency University Hospital, 011461 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3769-9746","authenticated-orcid":false,"given":"M\u0103d\u0103lina","family":"Chivu","sequence":"additional","affiliation":[{"name":"Department of Pathology, \u201cElias\u201d Emergency University Hospital, 011461 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana Gabriela","family":"Popa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Dermatology Clinic, \u201cElias\u201d Emergency University Hospital, 011461 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u0103lin","family":"Giurc\u0103neanu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Dermatology Clinic, \u201cElias\u201d Emergency University Hospital, 011461 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-5736","authenticated-orcid":false,"given":"Olgu\u021ba Anca","family":"Orzan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Dermatology Clinic, \u201cElias\u201d Emergency University Hospital, 011461 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ward, W.H., and Farma, J.M. 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