{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:38:44Z","timestamp":1790800724474,"version":"4.1.0"},"reference-count":34,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Non-valvular atrial fibrillation (NVAF) is the most common cardiac arrhythmia in the general population, and its prevalence increases among patients with chronic kidney disease (CKD) undergoing hemodialysis. This population presents high risk of both hemorrhagic and thrombotic events, with little evidence regarding the use of oral anticoagulation treatment (OAT) and multiple complications arising from it; however, stroke prevention with percutaneous left atrial appendage closure (LAAC) is an alternative to be considered. We retrospectively describe the safety and efficacy of percutaneous LAAC in eight patients with NVAF and CKD on hemodialysis during a 12-month follow-up. The mean age was 78.8 years (range 64\u201386; SD \u00b1 6.7), and seven patients were male. The mean CHA2DS2-VASC and HAS-BLED scores were high, 4.8 (SD \u00b1 1.5) and 3.8 (SD \u00b1 1.3), respectively. Seventy-five percent of the patients were referred for this intervention due to a history of major bleeding, with gastrointestinal bleeding being the most common type, while the remaining twenty-five percent of the patients were referred because of a high risk of bleeding. The percutaneous LAAC procedure was successfully completed in 100% of the patients, with complete exclusion of the appendage without complications or leaks exceeding 5 mm. There was one death not related to the procedure four days after the intervention. Among the other seven patients, no deaths, cardioembolic events or major bleeding were reported during the follow-up period. In our sample, percutaneous LAAC appears to be a safe and effective alternative to anticoagulation in patients with NVAF and CKD on hemodialysis.<\/jats:p>","DOI":"10.3390\/medicina60020231","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T08:11:27Z","timestamp":1706515887000},"page":"231","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Percutaneous Left Atrial Appendage Closure in Patients with Non-Valvular Atrial Fibrillation and End-Stage Renal Disease on Hemodialysis: A Case Series"],"prefix":"10.3390","volume":"60","author":[{"given":"Elena","family":"Basabe","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital Central Defense G\u00f3mez Ulla, 28047 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9346-2279","authenticated-orcid":false,"given":"Jos\u00e9 C.","family":"De La Flor","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Central Defense G\u00f3mez Ulla, 28047 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"L\u00f3pez de la Manzanara","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Cl\u00ednico San Carlos, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Nombela-Franco","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Cl\u00ednico San Carlos, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Narv\u00e1ez-Mej\u00eda","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Universitario Puerta del Mar, 11009 C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le\u00f3nidas","family":"Cruzado","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital General Elche, 03203 Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8982-8442","authenticated-orcid":false,"given":"Daniel","family":"Villa","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Cl\u00ednica Universidad de Navarra, 31008 Navarra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Zamora","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Universitario General Villalba, 28400 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Tapia","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Central Defense G\u00f3mez Ulla, 28047 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Sastre","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Central Defense G\u00f3mez Ulla, 28047 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edurne","family":"L\u00f3pez Sober\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Central Defense G\u00f3mez Ulla, 28047 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Herrero Calvo","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Cl\u00ednico San Carlos, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Central Defense G\u00f3mez Ulla, 28047 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5036-4943","authenticated-orcid":false,"given":"David","family":"Mart\u00ed S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Central Defense G\u00f3mez Ulla, 28047 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1161\/CIRCEP.110.957100","article-title":"Association of Chronic Kidney Disease With Atrial Fibrillation Among Adults in the United States: REasons for Geographic and Racial Differences in Stroke (REGARDS) Study","volume":"4","author":"Baber","year":"2011","journal-title":"Circ. 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