{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T15:22:36Z","timestamp":1793978556648,"version":"4.8.0"},"reference-count":42,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: The COVID-19 pandemic affects various populations worldwide. The discovery of vaccinations was necessary for the prevention and elimination of the disease. Despite the high importance of these vaccinations, they may cause some complications, such as ocular complications. This study aims to draw attention to the possible complications of the vaccination and highlight its importance. Materials and Methods: Systematic review of the literature from January 2021 to January 2023. A total of 20 published articles were included and reported cases of ocular complications in patients who received COVID-19 vaccines. Results: A total of 243 patients with verified ocular complications following the COVID-19 vaccination were included, ranging in age from 18 to 84 years. The most common ocular complications reported in the current study were ocular inflammatory complications, which represented 47.3%, followed by optic neuritis (24.3%). Retinal artery occlusion, retinal vein occlusion, acute macular neuroretinopathy, and paracentral acute middle maculopathy represented 10.7%. Herpetic ocular infections and herpetic eye disease (14%). Nearly half (42%) of the patients with ocular problems received the Pfizer-BioNTech vaccination. Conclusions: Despite the high importance of the COVID-19 vaccination, it was found that it is associated with the occurrence of some ocular complications. Future projects should come with more extensive prospective studies to further elucidate the underlying mechanisms and risk factors associated with ocular complications following COVID-19 vaccination, thereby enhancing our understanding and guiding appropriate management strategies.<\/jats:p>","DOI":"10.3390\/medicina60020249","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T09:41:59Z","timestamp":1706694119000},"page":"249","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ocular Complications after COVID-19 Vaccination: A Systematic Review"],"prefix":"10.3390","volume":"60","author":[{"given":"Eman A.","family":"Hurissi","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1316-9465","authenticated-orcid":false,"given":"Ismail I.","family":"Abuallut","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ophthalmology Division, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Qassem","family":"Dibaji","sequence":"additional","affiliation":[{"name":"Prince Mohammed Bin Naser Hospital, Jazan 82943, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6340-2762","authenticated-orcid":false,"given":"Abdulaziz","family":"Jaly","sequence":"additional","affiliation":[{"name":"Pharmacy, Jazan University Hospital, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4260-6540","authenticated-orcid":false,"given":"Abdulaziz H.","family":"Alhazmi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3635-1920","authenticated-orcid":false,"given":"Bandar M.","family":"Abuageelah","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Batterjee Medical College, Abha 62451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3998-6135","authenticated-orcid":false,"given":"Khalid M.","family":"Alameer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef M.","family":"Alyami","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Batterjee Medical College, Abha 62451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/d41573-020-00151-8","article-title":"The COVID-19 vaccine development landscape","volume":"19","author":"Le","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ijid.2021.08.013","article-title":"Side effects and perceptions following Sinopharm COVID-19 vaccination","volume":"111","author":"Saeed","year":"2021","journal-title":"Int. J. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.immuni.2010.10.006","article-title":"Systems Vaccinology","volume":"33","author":"Pulendran","year":"2010","journal-title":"Immunity"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00011-021-01506-6","article-title":"Adverse Ocular Events following COVID-19 Vaccination","volume":"70","author":"Eleiwa","year":"2021","journal-title":"Inflamm. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/ICO.0000000000002886","article-title":"Acute Corneal Transplant Rejection after Severe Acute Respiratory Syndrome Coronavirus 2 mRNA-1273 Vaccination","volume":"41","author":"Yu","year":"2022","journal-title":"Cornea"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1007\/s00417-022-05953-7","article-title":"Retinal vascular occlusions in COVID-19 infection and vaccination: A literature review","volume":"261","author":"Yeo","year":"2023","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1016\/j.jfo.2022.09.005","article-title":"Optic neuritis after COVID-19 infection: A case report","volume":"46","author":"Duran","year":"2023","journal-title":"J. Fr. D\u2019ophtalmologie"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"679","DOI":"10.4103\/ijo.IJO_2374_21","article-title":"Optic neuritis following COVID-19 vaccination: Coincidence or side-effect?-A case series","volume":"70","author":"Roy","year":"2022","journal-title":"Indian J. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Alvarez, L.M., Ning Neo, Y., Davagnanam, I., Ashenhurst, M., Acheson, J., Abdel-Hay, A., Alshowaeir, D., Bakheet, M., Balaguer, O., and Batra, R. (SSRN Electron J., 2021). Post Vaccination Optic Neuritis: Observations from the SARS-CoV-2 Pandemic, SSRN Electron J., preprint.","DOI":"10.2139\/ssrn.3889990"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1080\/09273948.2021.1962917","article-title":"Acute Uveitis following COVID-19 Vaccination","volume":"29","author":"ElSheikh","year":"2021","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1080\/09273948.2022.2042319","article-title":"Posterior Scleritis Following COVID-19 Vaccination: A Case Report","volume":"31","author":"Younus","year":"2022","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12348-021-00275-x","article-title":"Ocular inflammatory events following COVID-19 vaccination: A multinational case series","volume":"12","author":"Testi","year":"2022","journal-title":"J. Ophthalmic Inflamm. Infect."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Bolletta, E., Iannetta, D., Mastrofilippo, V., De Simone, L., Gozzi, F., Croci, S., Bonacini, M., Belloni, L., Zerbini, A., and Adani, C. (2021). Uveitis and Other Ocular Complications Following COVID-19 Vaccination. J. Clin. Med., 10.","DOI":"10.3390\/jcm10245960"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1080\/09273948.2022.2103831","article-title":"Herpetic Eye Disease Following the SARS-CoV-2 Vaccinations","volume":"31","author":"Cohen","year":"2022","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"823346","DOI":"10.3389\/fmed.2021.823346","article-title":"Case Report: Associated Ocular Adverse Reactions With Inactivated COVID-19 Vaccine in China","volume":"8","author":"Pang","year":"2022","journal-title":"Front. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e05471","DOI":"10.1002\/ccr3.5471","article-title":"Retinal hemorrhage of late post-COVID-19 and post-vaccine-related pathogenic mechanisms: A new challenge for ophthalmologist in COVID era","volume":"10","author":"Amin","year":"2022","journal-title":"Clin. Case Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1080\/09273948.2022.2046795","article-title":"Manifestation of Herpetic Eye Disease after COVID-19 Vaccine: A UK Case Series","volume":"30","author":"Rallis","year":"2022","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e445","DOI":"10.1016\/j.jfo.2021.06.001","article-title":"Acute corneal endothelial graft rejection following COVID-19 vaccination","volume":"44","author":"Crnej","year":"2021","journal-title":"J. Fr. D\u2019ophtalmologie"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1097\/ICO.0000000000002844","article-title":"Bilateral Immune-Mediated Keratolysis after Immunization with SARS-CoV-2 Recombinant Viral Vector Vaccine","volume":"40","author":"Sidhu","year":"2021","journal-title":"Cornea"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1080\/09273948.2022.2039211","article-title":"Peripheral Ulcerative Keratitis Secondary to the Inactive COVID-19 Vaccine-CoronaVac","volume":"31","author":"Penbe","year":"2022","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e01536","DOI":"10.1016\/j.idcr.2022.e01536","article-title":"Marginal keratitis following COVID 19 vaccination","volume":"29","author":"Farrell","year":"2022","journal-title":"IDCases"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e30041","DOI":"10.1097\/MD.0000000000030041","article-title":"Case report of transient corneal edema after immunization with adenovirus-vectored COVID-19 vaccine","volume":"101","author":"Lee","year":"2022","journal-title":"Medicine"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40942-022-00393-1","article-title":"Multiple attacks of transient monocular visual loss in a previously healthy man: A possible complication after COVID-19 vaccination?","volume":"8","author":"Cunha","year":"2022","journal-title":"Int. J. Retin. Vitr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/kjm2.12473","article-title":"Disc edema in one eye and central serous chorioretinopathy in the other eye shortly after AstraZeneca COVID-19 vaccination","volume":"38","author":"Lee","year":"2022","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1080\/09273948.2022.2058964","article-title":"COVID-19 Vaccination and Uveitis: Epidemiology, Clinical Features and Visual Prognosis","volume":"30","author":"Ferrand","year":"2022","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.4103\/jfmpc.jfmpc_747_22","article-title":"Ocular adverse effects of COVID-19 vaccines: A systematic review","volume":"11","author":"Kumari","year":"2022","journal-title":"J. Fam. Med. Prim. Care"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1007\/s10792-022-02565-2","article-title":"Posterior ocular manifestations following BNT162b2 mRNA COVID-19 vaccine: A case series","volume":"43","author":"Pillar","year":"2022","journal-title":"Int. Ophthalmol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Elnahry, A.G., Al-Nawaflh, M.Y., Eldin, A.A.G., Solyman, O., Sallam, A.B., Phillips, P.H., and Elhusseiny, A.M. (2022). COVID-19 Vaccine-Associated Optic Neuropathy: A Systematic Review of 45 Patients. Vaccines, 10.","DOI":"10.3390\/vaccines10101758"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.survophthal.2021.04.001","article-title":"Ocular adverse events following vaccination: Overview and update","volume":"67","author":"Cheng","year":"2022","journal-title":"Surv. Ophthalmol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Koganti, R., Yadavalli, T., and Shukla, D. (2019). Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections. Microorganisms, 7.","DOI":"10.3390\/microorganisms7100429"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"308","DOI":"10.4103\/ijo.IJO_1757_21","article-title":"Central retinal vein occlusion post-COVID-19 vaccination","volume":"70","author":"Sonawane","year":"2022","journal-title":"Indian J. Ophthalmol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Kuziez, L., Eleiwa, T.K., Chauhan, M.Z., Sallam, A.B., Elhusseiny, A.M., and Saeed, H.N. (2023). Corneal Adverse Events Associated with SARS-CoV-2\/COVID-19 Vaccination: A Systematic Review. Vaccines, 11.","DOI":"10.3390\/vaccines11010166"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.4049\/jimmunol.1600251","article-title":"Alloimmunity and Tolerance in Corneal Transplantation","volume":"196","author":"Amouzegar","year":"2016","journal-title":"J. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s40135-018-0191-2","article-title":"Regulatory T Cell Modulation of Cytokine and Cellular Networks in Corneal Graft Rejection","volume":"6","author":"Tahvildari","year":"2018","journal-title":"Curr. Ophthalmol. Rep."},{"key":"ref_36","first-page":"296","article-title":"Impact of vaccination on keratoplasty","volume":"33","author":"Dugan","year":"2022","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1136\/bjophthalmol-2021-319338","article-title":"Characteristics of endothelial corneal transplant rejection following immunisation with SARS-CoV-2 messenger RNA vaccine","volume":"105","author":"Phylactou","year":"2021","journal-title":"Br. J. Ophthalmol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Di Zazzo, A., Lee, S.-M., Sung, J., Niutta, M., Coassin, M., Mashaghi, A., and Inomata, T. (2020). Variable Responses to Corneal Grafts: Insights from Immunology and Systems Biology. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020586"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/s41586-021-03653-6","article-title":"BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans","volume":"595","author":"Sahin","year":"2021","journal-title":"Nature"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1097\/ICO.0000000000002662","article-title":"Survey of Corneal Surgeons\u2019 Attitudes regarding Keratoplasty Rejection Risk Associated with Vaccinations","volume":"40","author":"Lockington","year":"2021","journal-title":"Cornea"},{"key":"ref_41","first-page":"6","article-title":"Corneal Allograft Rejection: Immunopathogenesis to Therapeutics","volume":"2013","author":"Qazi","year":"2013","journal-title":"J. Clin. Cell. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/ICO.0000000000002878","article-title":"Acute Corneal Transplant Rejection after COVID-19 Vaccination","volume":"41","author":"Shah","year":"2022","journal-title":"Cornea"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/2\/249\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:52:14Z","timestamp":1760104334000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/2\/249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,31]]},"references-count":42,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["medicina60020249"],"URL":"https:\/\/doi.org\/10.3390\/medicina60020249","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,31]]}}}