{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:28:31Z","timestamp":1767835711304,"version":"3.49.0"},"reference-count":45,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>The prevalence of multivessel coronary artery disease (CAD) in acute coronary syndrome (ACS) patients underscores the need for optimal revascularization strategies. The ongoing debate surrounding percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), hybrid interventions, or medical-only management adds complexity to decision-making, particularly in specific angiographic scenarios. The article critically reviews existing literature, providing evidence-based perspectives on non-culprit lesion revascularization in ACS. Emphasis is placed on nuances such as the selection of revascularization methods, optimal timing for interventions, and the importance of achieving completeness in revascularization. The debate between culprit-only revascularization and complete revascularization is explored in detail, focusing on ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI), including patients with cardiogenic shock. Myocardial revascularization guidelines and recent clinical trials support complete revascularization strategies, either during the index primary PCI or within a short timeframe following the culprit lesion PCI (in both STEMI and NSTEMI). The article also addresses the complexities of decision-making in NSTEMI patients with multivessel CAD, advocating for immediate multivessel PCI unless complex coronary lesions require a staged revascularization approach. Finally, the article provided contemporary data on chronic total occlusion revascularization in ACS patients, highlighting the prognostic impact. In conclusion, the article addresses the evolving challenges of managing multivessel CAD in ACS patients, enhancing thoughtful integration into the clinical practice of recent data. We provided evidence-based, individualized approaches to optimize short- and long-term outcomes. The ongoing refinement of clinical and interventional strategies for non-culprit lesion management remains dynamic, necessitating careful consideration of patient characteristics, coronary stenosis complexity, and clinical context.<\/jats:p>","DOI":"10.3390\/medicina60020263","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T09:24:08Z","timestamp":1706865848000},"page":"263","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Updated Strategies in Non-Culprit Stenosis Management of Multivessel Coronary Disease\u2014A Contemporary Review"],"prefix":"10.3390","volume":"60","author":[{"given":"Rares-Dumitru","family":"Manuca","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Diseases \u201cProf. Dr. George I.M. Georgescu\u201d, 700503 Iasi, Romania"},{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra Maria","family":"Covic","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Diseases \u201cProf. Dr. George I.M. Georgescu\u201d, 700503 Iasi, Romania"},{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6253-3203","authenticated-orcid":false,"given":"Crischentian","family":"Brinza","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Diseases \u201cProf. Dr. George I.M. Georgescu\u201d, 700503 Iasi, Romania"},{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9465-1503","authenticated-orcid":false,"given":"Mariana","family":"Floria","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Iasi, Romania"},{"name":"Internal Medicine Clinic, \u201cSt. Spiridon\u201d County Clinical Emergency Hospital Iasi, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6439-4561","authenticated-orcid":false,"given":"Cristian","family":"Statescu","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Diseases \u201cProf. Dr. George I.M. Georgescu\u201d, 700503 Iasi, Romania"},{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9985-2486","authenticated-orcid":false,"given":"Adrian","family":"Covic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Iasi, Romania"},{"name":"Nephrology Clinic, Dialysis, and Renal Transplant Center, \u201cC.I. Parhon\u201d University Hospital, 700503 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3424-1588","authenticated-orcid":false,"given":"Alexandru","family":"Burlacu","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Diseases \u201cProf. Dr. George I.M. Georgescu\u201d, 700503 Iasi, Romania"},{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.hlc.2017.10.015","article-title":"All-Cause Mortality Following an Acute Coronary Syndrome: 12-Year Follow-up of the Comprehensive 2002 New Zealand Acute Coronary Syndrome Audit","volume":"28","author":"Ellis","year":"2019","journal-title":"Heart Lung Circ."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJMoa2307823","article-title":"Timing of Complete Revascularization with Multivessel Pci for Myocardial Infarction","volume":"389","author":"Varbella","year":"2023","journal-title":"N. Engl. J. 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