{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:47:19Z","timestamp":1785422839454,"version":"3.56.0"},"reference-count":47,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T00:00:00Z","timestamp":1706918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Granulomatosis with Polyangiitis (GPA) is a rare, autoimmune, multisystemic disease characterized by vasculitis and necrotizing granuloma that commonly affects the upper and lower respiratory tract and kidneys. Audiovestibular dysfunction in GPA diseases may have different clinical presentations. The aim of the present study was to evaluate hearing function in patients with GPA and to compare the results with a healthy control group. Materials and Methods: A total of 34 individuals participated in the study. The GPA group consisted of 14 participants, and the control group was composed of 20 healthy participants with no signs or symptoms of ear disease. The ages ranged from 18 to 65 years old, with a mean age of 43.8 years. The participants underwent a complete audiological evaluation using otoscopy, impedance audiometry, pure tone audiometry, speech audiometry\u2014evaluation of speech thresholds, and speech recognition in quiet. Both ears were tested. All of the participants of the study were native Lithuanian speakers. Data were statistically analyzed using the Statistical Analysis System software SAS\u00ae Studio 3.8. A p value &lt; 0.05 was regarded as statistically significant. Results: 92.85% of patients from the GPA group reported hearing-related symptoms: hearing loss, tinnitus, and fullness in the ears. The arithmetic means of all hearing thresholds at frequencies from 125 Hz to 8000 Hz were significantly higher in the GPA group. The results revealed statistically significant differences between the two groups in the Speech Detection Threshold, Speech Recognition Threshold, Speech Discomfort level, and Word Recognition Scores. Conclusions: The frequency of hearing loss, the average hearing thresholds, and speech thresholds were higher in GPA patients than in healthy individuals. The most common type of hearing loss was sensorineural. Audiological assessments should be considered during the routine evaluation of patients with GPA disease to prevent hearing-related disabilities.<\/jats:p>","DOI":"10.3390\/medicina60020267","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T08:41:43Z","timestamp":1707122503000},"page":"267","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Audiological Manifestations in Patients with Granulomatosis with Polyangiitis"],"prefix":"10.3390","volume":"60","author":[{"given":"Vija","family":"Vainutien\u0117","sequence":"first","affiliation":[{"name":"State Research Institute Centre for Innovative Medicine, Santari\u0161ki\u0173 str. 5, LT-08406 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8726-7570","authenticated-orcid":false,"given":"Justinas","family":"Iva\u0161ka","sequence":"additional","affiliation":[{"name":"Clinic of Ear, Nose, Throat and Eye Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, M.K. \u010ciurlionio str. 21, LT-03101 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Dadonien\u0117","sequence":"additional","affiliation":[{"name":"State Research Institute Centre for Innovative Medicine, Santari\u0161ki\u0173 str. 5, LT-08406 Vilnius, Lithuania"},{"name":"Department of Public Health, Faculty of Medicine, Vilnius University, M.K. \u010ciurlionio str. 21, LT-03101 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7610-2957","authenticated-orcid":false,"given":"Vilma","family":"Bele\u0161kien\u0117","sequence":"additional","affiliation":[{"name":"Clinic of Ear, Nose, Throat and Eye Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, M.K. \u010ciurlionio str. 21, LT-03101 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Iva\u0161kien\u0117","sequence":"additional","affiliation":[{"name":"State Research Institute Centre for Innovative Medicine, Santari\u0161ki\u0173 str. 5, LT-08406 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenijus","family":"Lesinskas","sequence":"additional","affiliation":[{"name":"Clinic of Ear, Nose, Throat and Eye Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, M.K. \u010ciurlionio str. 21, LT-03101 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/art.30286","article-title":"Granulomatosis with polyangiitis (Wegener\u2019s): An alternative name for Wegener\u2019s granulomatosis","volume":"63","author":"Falk","year":"2011","journal-title":"Arthritis Rheum."},{"key":"ref_2","first-page":"202","article-title":"Uber generalisierte, septische Gefaesserkrankungen","volume":"29","author":"Wegener","year":"1936","journal-title":"Verhandlungen Dtsch. 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