{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T04:47:21Z","timestamp":1769575641766,"version":"3.49.0"},"reference-count":23,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Syphilis, an infectious disease caused by the spirochete Treponema pallidum, represents a pervasive global epidemic. Secondary syphilis is typically marked by the emergence of highly contagious mucocutaneous manifestations, including non-pruritic rashes on the palms and soles of the feet, alopecia, mucous patches, and condyloma lata. Here, we report a rare case of a 30-year-old male with newly discovered type 2 diabetes mellitus who presented with severe odynophagia due to secondary syphilis, confirmed by both nontreponemal VDRL\/RPR and treponemal TPHA tests. Following the administration of a single-dose intramuscular injection of benzathine penicillin G 2.4 million units, the symptoms gradually decreased, allowing the patient to regain his health.<\/jats:p>","DOI":"10.3390\/medicina60020298","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T08:12:03Z","timestamp":1707466323000},"page":"298","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic and Therapeutic Approaches for a Diabetic Patient Presenting with Secondary Syphilis and Severe Odynophagia"],"prefix":"10.3390","volume":"60","author":[{"given":"Bramantono","family":"Bramantono","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia"},{"name":"Division of Tropical and Infectious Diseases, Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya 60286, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5730-2013","authenticated-orcid":false,"given":"Henry","family":"Sutanto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermawan","family":"Susanto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia"},{"name":"Division of Endocrinology, Metabolic Diseases and Diabetes, Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya 60286, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Vitanata","family":"Arfijanto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia"},{"name":"Division of Tropical and Infectious Diseases, Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya 60286, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usman","family":"Hadi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia"},{"name":"Division of Tropical and Infectious Diseases, Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya 60286, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"ref_1","unstructured":"(2023, October 28). World Health Organization Syphilis. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/syphilis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s40471-018-0138-z","article-title":"An Update on the Global Epidemiology of Syphilis","volume":"5","author":"Kojima","year":"2018","journal-title":"Curr. Epidemiol. Rep."},{"key":"ref_3","unstructured":"Tudor, M.E., Al Aboud, A.M., Leslie, S.W., and Gossman, W. (2023). Treasure Island, StatPearls Publishing."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jdcr.2021.01.025","article-title":"Condyloma Lata in Secondary Syphilis","volume":"10","author":"Pourang","year":"2021","journal-title":"JAAD Case Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1111\/imj.15407","article-title":"Renal Manifestations of Syphilis","volume":"51","author":"Shettigar","year":"2021","journal-title":"Intern. Med. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2991\/jegh.k.191028.001","article-title":"Epidemiology of Type 2 Diabetes\u2014Global Burden of Disease and Forecasted Trends","volume":"10","author":"Khan","year":"2020","journal-title":"J. Epidemiol. Glob. Health"},{"key":"ref_7","first-page":"442","article-title":"Type 2 Diabetes and Its Impact on the Immune System","volume":"16","author":"Berbudi","year":"2020","journal-title":"Curr. Diabetes Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.4103\/2230-8210.94253","article-title":"Infections in Patients with Diabetes Mellitus: A Review of Pathogenesis","volume":"16","author":"Casqueiro","year":"2012","journal-title":"Indian. J. Endocrinol. Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"559595","DOI":"10.3389\/fpubh.2021.559595","article-title":"Susceptibility for Some Infectious Diseases in Patients with Diabetes: The Key Role of Glycemia","volume":"9","year":"2021","journal-title":"Front. Public Health"},{"key":"ref_10","unstructured":"Oakley, A.M., and Krishnamurthy, K. (2024). Treasure Island, StatPearls Publishing."},{"key":"ref_11","first-page":"283","article-title":"Diagnosis and Management of Syphilis","volume":"68","author":"Brown","year":"2003","journal-title":"Am. Fam. Physician"},{"key":"ref_12","unstructured":"(2023, November 04). CDC Syphilis\u2014STI Treatment Guidelines, Available online: https:\/\/www.cdc.gov\/std\/treatment-guidelines\/syphilis.htm."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/infdis\/jiy241","article-title":"Origin of Nontreponemal Antibodies During Treponema Pallidum Infection: Evidence from a Rabbit Model","volume":"218","author":"Gao","year":"2018","journal-title":"J. Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1001\/jama.1917.04270040220005","article-title":"The relation between diabetes mellitus and clinical syphilis","volume":"LXVIII","author":"Rosenbloom","year":"1917","journal-title":"J. Am. Med. Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1001\/jama.1918.02600060011004","article-title":"Syphilis as a cause of diabetes mellitus: Relation of wassermann test and of lipoidemia","volume":"70","author":"Williams","year":"1918","journal-title":"J. Am. Med. Assoc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/1753-0407.12119","article-title":"Association between Neurosyphilis and Diabetes Mellitus: Resurgence of an Old Problem","volume":"6","author":"Yang","year":"2014","journal-title":"J. Diabetes"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13568-020-01009-3","article-title":"Identification of Key Genes and Pathways in Syphilis Combined with Diabetes: A Bioinformatics Study","volume":"10","author":"Li","year":"2020","journal-title":"AMB Expr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.clinbiochem.2019.03.012","article-title":"What Is the Optimal Time for Measuring Glucose Concentration to Detect Steroid-Induced Hyperglycemia in Patients with Rheumatic Diseases?","volume":"67","author":"Cansu","year":"2019","journal-title":"Clin. Biochem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4093\/jkd.2016.17.3.174","article-title":"Management of Steroid-Induced Hyperglycemia","volume":"17","author":"Suh","year":"2016","journal-title":"J. Korean Diabetes"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0749-0704(05)70154-8","article-title":"Stress-Induced Hyperglycemia","volume":"17","author":"McCowen","year":"2001","journal-title":"Crit. Care Clin."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1146\/annurev.nutr.24.012003.132159","article-title":"Defective Glucose Homeostasis during Infection","volume":"25","author":"McGuinness","year":"2005","journal-title":"Annu. Rev. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Cruz, A.R., Ramirez, L.G., Zuluaga, A.V., Pillay, A., Abreu, C., Valencia, C.A., Vake, C.L., Cervantes, J.L., Dunham-Ems, S., and Cartun, R. (2012). Immune Evasion and Recognition of the Syphilis Spirochete in Blood and Skin of Secondary Syphilis Patients: Two Immunologically Distinct Compartments. PLoS Neglected Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001717"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e00793","DOI":"10.14309\/crj.0000000000000793","article-title":"Syphilis in the Esophagus","volume":"9","author":"Allencherril","year":"2022","journal-title":"ACG Case Rep. J."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/2\/298\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:57:53Z","timestamp":1760104673000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/2\/298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,9]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["medicina60020298"],"URL":"https:\/\/doi.org\/10.3390\/medicina60020298","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,9]]}}}