{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T20:14:04Z","timestamp":1775852044908,"version":"3.50.1"},"reference-count":51,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"King Saud University","award":["RSP2024R382"],"award-info":[{"award-number":["RSP2024R382"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background: Understanding post-stroke fatigue (PSF) and its associated factors is crucial for effective therapy and rehabilitation. This study aimed to assess the mediating role of the excessive daytime sleepiness-related functional status (SFS) on the relationship between sleep and the severity of fatigue in subacute stroke survivors. Methods: Subacute stroke survivors (n = 50; male = 38; female = 12), completed a cross-sectional study involving the Pittsburgh sleep quality index (PSQI), the Epworth sleepiness scale (ESS), the insomnia severity index (ISI), the functional outcome of the sleep questionnaire (FOSQ), and the fatigue severity scale (FSS). Results: The SFS mediated the association between the severity of fatigue and sleep problems. The PSQI and FOSQ (b = \u22120.37, p &lt; 0.001), and the FOSQ and FSS were correlated (b = \u22120.18, p &lt; 0.05), with a significant indirect effect of the PSQI on the FSS. The ISI correlated with the FOSQ (b = \u22120.20, p &lt; 0.001), with significant direct (b = 0.15, p &lt; 0.001), as well as indirect, effects of the ISI on the FSS. The ESS correlated with the FOSQ (b = \u22120.23, p &lt; 0.001), with a significant indirect effect of the ESS on the FSS. Conclusions: In subacute stroke survivors, fatigue and sleep are linked. Increased understanding of sleep-PSF may help in exploring new targets for supplement therapy.<\/jats:p>","DOI":"10.3390\/medicina60030422","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T06:07:53Z","timestamp":1709273273000},"page":"422","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the Mediating Role of Sleep Deficit-Related Functional Status in Subacute Stroke Survivors"],"prefix":"10.3390","volume":"60","author":[{"given":"Sunil","family":"Kumar","sequence":"first","affiliation":[{"name":"Center for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia, New Delhi 110025, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Parveen","sequence":"additional","affiliation":[{"name":"Center for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia, New Delhi 110025, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5571-3310","authenticated-orcid":false,"given":"Md Dilshad","family":"Manzar","sequence":"additional","affiliation":[{"name":"Department of Nursing, College of Applied Medical Sciences, Majmaah University, Majmaah 11952, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1204-476X","authenticated-orcid":false,"given":"Ahmad H.","family":"Alghadir","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8051-142X","authenticated-orcid":false,"given":"Masood","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid Wasel","family":"Al-Quliti","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine, Taibah University, Madinah 42353, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Warren","family":"Spence","sequence":"additional","affiliation":[{"name":"Independent Researcher, 652 Dufferin Street, Toronto, ON M6K 2b4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8686-7259","authenticated-orcid":false,"given":"Seithikurippu R.","family":"Pandi-Perumal","sequence":"additional","affiliation":[{"name":"Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, India"},{"name":"Division of Research and Development, Lovely Professional University, Phagwara 144411, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1706-6167","authenticated-orcid":false,"given":"Ahmed S.","family":"Bahammam","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majumi M.","family":"Noohu","sequence":"additional","affiliation":[{"name":"Center for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia, New Delhi 110025, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1111\/j.1460-9568.2009.06767.x","article-title":"Sleep function: Current questions and new approaches","volume":"29","author":"Vassalli","year":"2009","journal-title":"Eur. 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