{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:20:44Z","timestamp":1789683644027,"version":"4.0.1"},"reference-count":39,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Peri-implant diseases including peri-implant mucositis and peri-implantitis are among the major causes of failure of implant-supported dental restorations. They are characterized by progressive inflammation of the peri-implant mucosa, extending to the surrounding connective tissues and leading to bone loss and implant failure. Although strict oral hygiene practices help in preventing peri-implant diseases, plaque buildup around the implant restoration leads to chronic inflammation, due to the adherent bacterial biofilm. While mechanical debridement and non-surgical therapy to remove inflamed connective tissue (ICT) form the mainstay of treatment, additional local adjunctive therapies enhance clinical outcomes. Topical oxygen therapy is known to reduce inflammation, increase vascularity, and act as a bacteriostatic measure. The use of oxygen-based therapy (blue\u00aem) products as a local adjunctive therapy for peri-implant mucositis and peri-implantitis can result in clinical outcomes similar to that of conventional local adjuncts such as chlorhexidine, antibiotics, and antibacterial agents. This report aims to present the clinical findings of patients with peri-implant mucositis and peri-implantitis, who were managed using local oxygen-based therapy as an adjunct to non-surgical therapy. In addition, a review of the literature about commonly used local adjuncts for peri-implant diseases has been included in the report to provide a means of comparison between conventional local adjunct therapy and topical oxygen-based therapy. Based on the reported findings and reviewed literature, local oxygen-based adjunct therapy was equally effective as conventionally used local adjuncts such as antibiotics, antibacterials, and probiotics, in treating patients with peri-implant diseases.<\/jats:p>","DOI":"10.3390\/medicina60030447","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T03:52:11Z","timestamp":1709869931000},"page":"447","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Local Oxygen-Based Therapy (blue\u00aem) for Treatment of Peri-Implant Disease: Clinical Case Presentation and Review of Literature about Conventional Local Adjunct Therapies"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6638-0075","authenticated-orcid":false,"given":"Marwa Y.","family":"Shaheen","sequence":"first","affiliation":[{"name":"Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irfan","family":"Abas","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology and Restorative Dentistry, Academy and Private Practice, Herenstraat 37, 1404 HC Bussum, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3577-2161","authenticated-orcid":false,"given":"Amani M.","family":"Basudan","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8247-3367","authenticated-orcid":false,"given":"Hamdan S.","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s40729-021-00388-x","article-title":"Efficacy of alternative or adjunctive measures to conventional non-surgical and surgical treatment of peri-implant mucositis and peri-implantitis: A systematic review and meta-analysis","volume":"7","author":"Ramanauskaite","year":"2021","journal-title":"Int. J. Implant Dent."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S286","DOI":"10.1111\/jcpe.12957","article-title":"Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions","volume":"45","author":"Berglundh","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jcpe.13823","article-title":"Prevention and treatment of peri-implant diseases-the efp s3 level clinical practice guideline","volume":"50","author":"Herrera","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/prd.12049","article-title":"Management of peri-implant mucositis and peri-implantitis","volume":"66","author":"Figuero","year":"2014","journal-title":"Periodontology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S202","DOI":"10.1111\/jcpe.12349","article-title":"Efficacy of professionally administered plaque removal with or without adjunctive measures for the treatment of peri-implant mucositis. A systematic review and meta-analysis","volume":"42","author":"Schwarz","year":"2015","journal-title":"J. Clin. Periodontol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/clr.12612","article-title":"Treatment of peri-implantitis: Clinical outcome of chloramine as an adjunctive to non-surgical therapy, a randomized clinical trial","volume":"28","author":"Jansson","year":"2017","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/cre2.286","article-title":"A nonsurgical treatment of peri-implantitis using mechanic, antiseptic and anti-inflammatory treatment: 1 year follow-up","volume":"6","author":"Mayer","year":"2020","journal-title":"Clin. Exp. Dent. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/jcpe.13663","article-title":"Adjuvant use of multispecies probiotic in the treatment of peri-implant mucositis: A randomized controlled trial","volume":"49","author":"Santana","year":"2022","journal-title":"J. Clin. Periodontol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1007\/s00784-016-2033-7","article-title":"Effects of enamel matrix derivative on non-surgical management of peri-implant mucositis: A double-blind randomized clinical trial","volume":"21","author":"Kashefimehr","year":"2017","journal-title":"Clin. Oral Investig."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/clr.13555","article-title":"The usage of a lactobacilli probiotic in the non-surgical therapy of peri-implantitis: A randomized pilot study","volume":"31","author":"Laleman","year":"2020","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_11","first-page":"255","article-title":"A new multiple anti-infective non-surgical therapy in the treatment of peri-implantitis: A case series","volume":"66","author":"Mensi","year":"2017","journal-title":"Minerva Stomatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/jcpe.13088","article-title":"Clinical effects of the adjunctive use of a 0.03% chlorhexidine and 0.05% cetylpyridinium chloride mouth rinse in the management of peri-implant diseases: A randomized clinical trial","volume":"46","author":"Pulcini","year":"2019","journal-title":"J. Clin. Periodontol."},{"key":"ref_13","first-page":"S43","article-title":"Antibiotics in the treatment of peri-implantitis","volume":"5","year":"2012","journal-title":"Eur. J. Oral Implantol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/jcpe.13794","article-title":"The efficacy of implant surface decontamination using chemicals during surgical treatment of peri-implantitis: A systematic review and meta-analysis","volume":"50","author":"Wilensky","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"ref_15","first-page":"5698","article-title":"Efficacy of adjunct subgingival minocycline delivery for treatment of peri-implantitis in moderate cigarette smokers","volume":"26","author":"Alhumaidan","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1600-051X.2006.00919.x","article-title":"Topical minocycline microspheres versus topical chlorhexidine gel as an adjunct to mechanical debridement of incipient peri-implant infections: A randomized clinical trial","volume":"33","author":"Renvert","year":"2006","journal-title":"J. Clin. Periodontol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1563\/aaid-joi-D-20-00259","article-title":"Efficacy of antibiotic versus probiotics as adjuncts to mechanical debridement for the treatment of peri-implant mucositis","volume":"48","author":"Alqahtani","year":"2022","journal-title":"J. Oral Implantol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/idh.12002","article-title":"Topical application of 1% chlorhexidine gel versus 0.2% mouthwash in the treatment of peri-implant mucositis. An observational study","volume":"11","author":"Francetti","year":"2013","journal-title":"Int. J. Dent. Hyg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/jcpe.13747","article-title":"Efficacy of professionally administered chemical agents as an adjunctive treatment to sub-marginal instrumentation during the therapy of peri-implant mucositis","volume":"50","author":"Dommisch","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/jcpe.13295","article-title":"Adjunctive effect of mouthrinse on treatment of peri-implant mucositis using mechanical debridement: A randomized clinical trial","volume":"47","author":"Philip","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1016\/j.ajic.2013.05.002","article-title":"Chlorhexidine activity against bacterial biofilms","volume":"41","author":"Bonez","year":"2013","journal-title":"Am. J. Infect. Control"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Pa\u0142ka, \u0141., Nowakowska-Toporowska, A., and Dalewski, B. (2022). Is chlorhexidine in dentistry an ally or a foe? A narrative review. Healthcare, 10.","DOI":"10.3390\/healthcare10050764"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.sdentj.2022.04.005","article-title":"Comparative study of the effect of bluem active oxygen gel and coe-pack dressing on postoperative surgical depigmentation healing","volume":"34","author":"Juliana","year":"2022","journal-title":"Saudi Dent. J."},{"key":"ref_24","first-page":"5535807","article-title":"Mouthwash with active oxygen (blue\u00aem) reduces postoperative inflammation and pain","volume":"2021","author":"Mattei","year":"2021","journal-title":"Case Rep. Dent."},{"key":"ref_25","first-page":"e49164","article-title":"Efficacy of oxygen-enriched mouthwash as a pre-procedural mouth rinse against oral microbes produced during ultrasonic scaling","volume":"15","author":"Sindhusha","year":"2023","journal-title":"Cureus"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1111\/cid.13049","article-title":"Surgical approach combining implantoplasty and reconstructive therapy with locally delivered antibiotic in the treatment of peri-implantitis: A prospective clinical case series","volume":"23","author":"Montero","year":"2021","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1902\/jop.2002.73.10.1118","article-title":"Clinical response to 2 different therapeutic regimens to treat peri-implant mucositis","volume":"73","author":"Porras","year":"2002","journal-title":"J. Periodontol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1600-0501.2010.02078.x","article-title":"Anti-infective treatment of peri-implant mucositis: A randomised controlled clinical trial","volume":"22","author":"Salvi","year":"2011","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1007\/s00784-019-03060-2","article-title":"Anti-infective therapy of peri-implant mucositis with adjunctive delivery of a sodium hypochlorite gel: A 6-month randomized triple-blind controlled clinical trial","volume":"24","author":"Blasi","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1034\/j.1600-0501.2001.012004287.x","article-title":"Treatment of peri-implantitis by local delivery of tetracycline. Clinical, microbiological and radiological results","volume":"12","author":"Mombelli","year":"2001","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_31","first-page":"133","article-title":"Water jet with adjunct chlorhexidine gel for nonsurgical treatment of peri-implantitis","volume":"46","author":"Levin","year":"2015","journal-title":"Quintessence Int."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/JPER.20-0353","article-title":"Repeated delivery of chlorhexidine chips for the treatment of peri-implantitis: A multicenter, randomized, comparative clinical trial","volume":"92","author":"Machtei","year":"2021","journal-title":"J. Periodontol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/cid.13006","article-title":"Adjunctive use of metronidazole-minocycline ointment in the nonsurgical treatment of peri-implantitis: A multicenter randomized controlled trial","volume":"23","author":"Park","year":"2021","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Passarelli, P.C., Netti, A., Lopez, M.A., Giaquinto, E.F., De Rosa, G., Aureli, G., Bodnarenko, A., Papi, P., Starzy\u0144ska, A., and Pompa, G. (2021). Local\/topical antibiotics for peri-implantitis treatment: A systematic review. Antibiotics, 10.","DOI":"10.3390\/antibiotics10111298"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"102231","DOI":"10.1016\/j.pdpdt.2021.102231","article-title":"Antimicrobial photodynamic therapy versus antibiotics as an adjunct in the treatment of periodontitis and peri-implantitis: A systematic review and meta-analysis","volume":"34","author":"Zhao","year":"2021","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1902\/jop.2006.77.1.31","article-title":"Local oxygen therapy for treating acute necrotizing periodontal disease in smokers","volume":"77","author":"Gaggl","year":"2006","journal-title":"J. Periodontol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"152","DOI":"10.4103\/jehp.jehp_66_18","article-title":"Periodontal therapy as an adjunctive modality for hba1c reduction in type-2 diabetic patients","volume":"7","author":"Sundar","year":"2018","journal-title":"J. Educ. Health Promot."},{"key":"ref_38","unstructured":"Alghamdi, H., and Jansen, J. (2020). Dental Implants and Bone Grafts, Woodhead Publishing."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.sdentj.2014.11.003","article-title":"Clinical evaluation of implant survival based on size and site of placement: A retrospective study of immediate implants at single rooted teeth sites","volume":"27","author":"Ramalingam","year":"2015","journal-title":"Saudi Dent. J."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/3\/447\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:10:48Z","timestamp":1760105448000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/3\/447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,8]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["medicina60030447"],"URL":"https:\/\/doi.org\/10.3390\/medicina60030447","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,8]]}}}