{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T03:48:36Z","timestamp":1788666516199,"version":"build-2803163510"},"reference-count":35,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T00:00:00Z","timestamp":1709942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background: Takayasu\u2019s arteritis is a rare type of vasculitis with severe complications like stroke, ischemic heart disease, pulmonary hypertension, secondary hypertension, and aneurysms. Diagnosis is achieved using clinical and angiographic criteria. Treatment is medical and surgical, but unfortunately, the outcome is limited. Case presentation: A 34-year-old Caucasian woman had an ischemic stroke (2009). She was diagnosed with Takayasu\u2019s arteritis and received treatment with methotrexate, prednisolone, and antiplatelet agents, with a mild improvement in clinical state. After 6 years (2015), she experienced an ascending aorta aneurysm, pulmonary hypertension, and mild aortic regurgitation. Surgical treatment solved both the ascending aorta aneurysm and left carotid artery stenosis (ultrasound in 2009 and computed tomography angiogram in 2014). Morphopathology revealed a typical case of Takayasu\u2019s arteritis. Tumor necrosis factor inhibitors (TNF inhibitors) were prescribed with methotrexate. At 48 years old (2023), she developed coronary heart disease (angina, electrocardiogram); echocardiography revealed severe pulmonary hypertension, and angiography revealed normal coronary arteries, abdominal aorta pseudoaneurysm, and arterial\u2013venous fistula originating in the right coronary artery with drainage in the medium pulmonary artery. The patient refused surgical\/interventional treatment. She again received TNF inhibitors, methotrexate, antiplatelet agents, and statins. Conclusions: This case report presented a severe form of Takayasu\u2019s arteritis. Our patient had multiple arterial complications, as previously mentioned. She received immunosuppressive treatment, medication targeted to coronary heart disease, and surgical therapy.<\/jats:p>","DOI":"10.3390\/medicina60030456","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T07:25:32Z","timestamp":1710141932000},"page":"456","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Takayasu\u2019s Arteritis: A Special Case Report and Review of the Literature"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0672-7289","authenticated-orcid":false,"given":"Paloma","family":"Moisii","sequence":"first","affiliation":[{"name":"1st Medical Department, \u201cGr. T. Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"\u201cPromedicanon\u201d Cardiology Office, 15 Prisacii Valley, Valea Lupului, 707410 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4636-3974","authenticated-orcid":false,"given":"Irina","family":"Jari","sequence":"additional","affiliation":[{"name":"2nd Surgical Department, \u201cGr. T. Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"\u201cSf. Spiridon\u201d Emergency Hospital, Radiology and Medical Imaging Clinique, 1st Independentei Avenue, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6894-673X","authenticated-orcid":false,"given":"Alexandru Gratian","family":"Naum","sequence":"additional","affiliation":[{"name":"2nd Morphofunctional Sciences Department, Biophysics and Medical Physics, \u201cGr. T. Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"\u201cNeolife\u201d Medical Center, 52 Carol I Avenue, 700503 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1377-1504","authenticated-orcid":false,"given":"Doina","family":"Butcovan","sequence":"additional","affiliation":[{"name":"1st Morpho-Functional Sciences Department, \u201cGr. T. Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"Pathology Department, \u201cProf. Dr. George Georgescu\u201d Institute of Cardiovascular Diseases, 50 Carol I Avenue, 700503 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigore","family":"Tinica","sequence":"additional","affiliation":[{"name":"1st Surgery Department\u2014Cardiac Surgery, \u201cGr. T. Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"Cardiac Surgery Department, \u201cProf. Dr. George Georgescu\u201d Institute of Cardiovascular Diseases, 50 Carol I Avenue, 700503 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,9]]},"reference":[{"key":"ref_1","first-page":"e400","article-title":"Takayasu\u2019s arteritis: Recent advances and clinical pitfalls","volume":"4","author":"Tombetti","year":"2022","journal-title":"Beyond Reum."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00015458.2000.12098506","article-title":"Takayasu arteritis","volume":"100","author":"Desiron","year":"2000","journal-title":"Acta Chir. 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