{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:53:59Z","timestamp":1760144039330,"version":"build-2065373602"},"reference-count":45,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:00:00Z","timestamp":1710547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy Timisoara, Romania","award":["5EXP\/1244\/30.01.2020"],"award-info":[{"award-number":["5EXP\/1244\/30.01.2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Nucleotide delivery has emerged as a noteworthy research trend in recent years because of its potential utility in addressing a range of genetic defects resulting in the presence of incorrect nucleotides. The primary goals of this research were to create and to characterize polyurethane microstructures, with the aim of utilizing them for nucleotide transport. Materials and Methods: Two samples were prepared using an aliphatic diisocyanate in reaction with a mixture of polyethylene glycol and polycaprolactone diol, where 2\u2032-deoxycytidinic acid was used as the active agent and glycerol 1,2-diacetate was used as an enhancer of the aqueous solubility. The solubility, pH, size distribution, and surface charge of the samples were measured, and encapsulation efficacy and release, cell proliferation, and irritation tests on mouse skin were conducted. Results: The results showed almost neutral acidic\u2013basic structures with a high heterogeneity, and a medium tendency to form clusters with non-cytotoxic and non-irritative potentials. Conclusions: Future research could explore the efficacy of this carrier in delivering other nucleotides, as well as investigating the long-term effects and safety of these microstructures in vivo.<\/jats:p>","DOI":"10.3390\/medicina60030491","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T06:58:39Z","timestamp":1710745119000},"page":"491","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polyurethane Microstructures for 2\u2032-Deoxycytidinic Acid Delivery: Preparation and Preliminary Characterization"],"prefix":"10.3390","volume":"60","author":[{"given":"Roxana Maria","family":"Jeleriu","sequence":"first","affiliation":[{"name":"PhD School, Faculty of Medicine, Department of Microscopic Morphology, Genetics Discipline, Center of Genomic Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2 E. Murgu, Sq., 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdana","family":"Cavaloiu","sequence":"additional","affiliation":[{"name":"PhD School, Faculty of Medicine, Department of Microscopic Morphology, Genetics Discipline, Center of Genomic Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2 E. Murgu, Sq., 300041 Timisoara, Romania"},{"name":"Department of Radiology, \u201cVictor Gomoiu\u201d Children\u2019s Clinical Hospital, 21 Basarabia Blvd., 022102 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia Manuela","family":"Onofrei","sequence":"additional","affiliation":[{"name":"PhD School, Faculty of Medicine, Department of Microscopic Morphology, Genetics Discipline, Center of Genomic Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2 E. Murgu, Sq., 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3406-0303","authenticated-orcid":false,"given":"Florin","family":"Borcan","sequence":"additional","affiliation":[{"name":"Department I, Advanced Instrumental Screening Center, Faculty of Pharmacy, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 E. Murgu Sq., 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramona Carmen","family":"Albulescu","sequence":"additional","affiliation":[{"name":"Department XI (Pediatrics II), Faculty of Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2 E. Murgu, Sq., 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Puiu","sequence":"additional","affiliation":[{"name":"Department II (Microscopic Morphology), Genetics Discipline, Center of Genomic Medicine, Faculty of Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2 E. Murgu, Sq., 300041 Timisoara, Romania"},{"name":"Clinical Emergency Hospital for Children \u201cLouis Turcanu\u201d, Regional Center of Medical Genetics, 2 Dr. I. Nemoianu, 300011 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9431","DOI":"10.3390\/ijms16059431","article-title":"Nucleotide salvage deficiencies, DNA damage and neurodegeneration","volume":"16","author":"Fasullo","year":"2015","journal-title":"Int. J. Mol. 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