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The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the development of the modern two-stage implantation technique. The quadripolar lead is positioned percutaneously under fluoroscopy guidance through the third sacral foramen following the trajectory of S3. The procedure can be performed under local or general anesthesia with the patient in prone position. Current applications of sacral neuromodulation in urology are increasing thanks to the recent improvements of the devices that make this a valuable option not only in conditions such as overactive bladder and non-obstructing urinary retention but also neurogenic lower urinary tract dysfunction.<\/jats:p>","DOI":"10.3390\/medicina60030509","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T13:09:36Z","timestamp":1710940176000},"page":"509","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Sacral Neuromodulation: Device Improvement and Current Applications in Urology"],"prefix":"10.3390","volume":"60","author":[{"given":"Marco","family":"Spilotros","sequence":"first","affiliation":[{"name":"Andrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area-Urology, University of Bari \u201cAldo Moro\u201d, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Gerbasi","sequence":"additional","affiliation":[{"name":"Andrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area-Urology, University of Bari \u201cAldo Moro\u201d, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8884-0757","authenticated-orcid":false,"given":"Francesco","family":"Lasorsa","sequence":"additional","affiliation":[{"name":"Andrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area-Urology, University of Bari \u201cAldo Moro\u201d, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"de Rienzo","sequence":"additional","affiliation":[{"name":"Andrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area-Urology, University of Bari \u201cAldo Moro\u201d, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Balducci","sequence":"additional","affiliation":[{"name":"Radiology Unit, University of Bari \u201cAldo Moro\u201d, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7718-7676","authenticated-orcid":false,"given":"Pasquale","family":"Ditonno","sequence":"additional","affiliation":[{"name":"Andrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area-Urology, University of Bari \u201cAldo Moro\u201d, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7807-1229","authenticated-orcid":false,"given":"Giuseppe","family":"Lucarelli","sequence":"additional","affiliation":[{"name":"Andrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area-Urology, University of Bari \u201cAldo Moro\u201d, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"ref_1","first-page":"276","article-title":"Experiences Sur Les Foilctions Des Racines Des Nerfsrachidiens","volume":"2","author":"Magendie","year":"1822","journal-title":"J. Physiol. Exp. Pathol."},{"key":"ref_2","unstructured":"Saxtorph, M.H. (1878). Strictura urethrae\u2013Fistula perinei\u2013Retentio urinae, Clinisk Chirurgi, Gyldendalske Forlag."},{"key":"ref_3","unstructured":"McGuire, W.F. (1955). Response of the Neurogenic Bladder to Various Electric Stimuli. [Thesis, Department of Surgery, Bowman Gray School of Medicine]."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1136\/bmj.3.5558.150","article-title":"Treatment of Stress Incontinence by Maximum Perineal Electrical Stimulation","volume":"3","author":"Moore","year":"1967","journal-title":"BMJ"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0022-5347(17)59647-0","article-title":"Treatment of Urinary Incontinence by An Implantable Prosthetic Urinary Sphincter","volume":"112","author":"Scott","year":"1974","journal-title":"J. Urol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1136\/jnnp.49.10.1104","article-title":"Sacral Anterior Root Stimulators for Bladder Control in Paraplegia: The First 50 Cases","volume":"49","author":"Brindley","year":"1986","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.juro.2017.06.074","article-title":"Real-Time Changes in Brain Activity during Sacral Neuromodulation for Overactive Bladder","volume":"198","author":"Gill","year":"2017","journal-title":"J. Urol."},{"key":"ref_8","unstructured":"(2024, February 16). Available online: https:\/\/europe.medtronic.com\/xd-en\/healthcare-professionals\/products\/urology\/sacral-neuromodulation-systems\/interstim-ii.html."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/S0022-5347(17)42038-6","article-title":"Electrical Stimulation in the Clinical Management of the Neurogenic Bladder","volume":"140","author":"Tanagho","year":"1988","journal-title":"J. Urol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1097\/01.ju.0000092634.64580.9a","article-title":"New Sacral Neuromodulation Lead for Percutaneous Implantation Using Local Anesthesia: Description and First Experience","volume":"170","author":"Spinelli","year":"2003","journal-title":"J. Urol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s12325-019-01205-z","article-title":"New Technologies and Applications in Sacral Neuromodulation: An Update","volume":"37","author":"Knowles","year":"2020","journal-title":"Adv. Ther."},{"key":"ref_12","unstructured":"(2024, February 16). Available online: https:\/\/www.axonics.com\/en-au\/."},{"key":"ref_13","first-page":"267","article-title":"Prospective Randomized Feasibility Study Assessing the Effect of Cyclic Sacral Neuromodulation on Urinary Urge Incontinence in Women","volume":"24","author":"Siegel","year":"2018","journal-title":"Urogynecology"},{"key":"ref_14","first-page":"S9","article-title":"Three Month Clinical Results with a Rechargeable Sacral Neuromodulation System for the Treatment of Overactive Bladder","volume":"37","author":"Blok","year":"2018","journal-title":"Neurourol. Urodyn."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.juro.2018.05.095","article-title":"Can Lumbosacral Magnetic Resonance Imaging Be Performed Safely in Patients with a Sacral Neuromodulation Device? An In Vivo Prospective Study","volume":"200","author":"Gill","year":"2018","journal-title":"J. Urol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1540-8159.2005.50024.x","article-title":"Current Clinical Issues for MRI Scanning of Pacemaker and Defibrillator Patients","volume":"28","author":"Kalin","year":"2005","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1002\/nau.23515","article-title":"International Continence Society Best Practice Statement for Use of Sacral Neuromodulation","volume":"37","author":"Goldman","year":"2018","journal-title":"Neurourol. Urodyn."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.37358\/RC.17.7.5694","article-title":"A Risk Assessment of Clostridium Difficile Infection after Antibiotherapy for Urinary Tract Infections in the Urology Department for Hospitalized Patients","volume":"68","author":"Grigore","year":"2017","journal-title":"Rev. Chim."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.purol.2013.04.018","article-title":"Recommandations de bonnes pratiques cliniques: Antibioprophylaxie et neuromodulation des racines sacr\u00e9es par le Comit\u00e9 d\u2019infectiologie de l\u2019Association fran\u00e7aise d\u2019urologie (CIAFU) et le Comit\u00e9 de neuro-urologie de l\u2019AFU","volume":"23","author":"Doublet","year":"2013","journal-title":"Progr\u00e8s Urol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.urpr.2014.07.003","article-title":"National Practice Patterns of Infection Prophylaxis for Sacral Neuromodulation Device: A Survey of High Volume Providers","volume":"2","author":"Lee","year":"2015","journal-title":"Urol. Pract."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3171\/2014.9.SPINE13667","article-title":"Functional Variability of Sacral Roots in Bladder Control","volume":"21","author":"Carlucci","year":"2014","journal-title":"J. Neurosurg. Spine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.eururo.2018.02.011","article-title":"Two-Year Outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for Refractory Urgency Urinary Incontinence: A Randomized Trial","volume":"74","author":"Amundsen","year":"2018","journal-title":"Eur. Urol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.urology.2016.04.024","article-title":"Three-Year Follow-up Results of a Prospective, Multicenter Study in Overactive Bladder Subjects Treated with Sacral Neuromodulation","volume":"94","author":"Siegel","year":"2016","journal-title":"Urology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.urology.2016.06.004","article-title":"Sacral Neuromodulation in Urological Practice","volume":"99","author":"Liberman","year":"2017","journal-title":"Urology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.juro.2017.11.066","article-title":"Motor Response Matters: Optimizing Lead Placement Improves Sacral Neuromodulation Outcomes","volume":"199","author":"Gill","year":"2018","journal-title":"J. Urol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.juro.2013.01.013","article-title":"Patterns of Hardware Related Electrode Failures in Sacral Nerve Stimulation Devices","volume":"190","author":"Lenis","year":"2013","journal-title":"J. Urol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1590\/s1677-5538.ibju.2021.99.08","article-title":"Sacral Neuromodulation\u2014When and for Who","volume":"47","author":"Goldman","year":"2021","journal-title":"Int. Braz. J. Urol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.juro.2017.07.010","article-title":"Five-Year Followup Results of a Prospective, Multicenter Study of Patients with Overactive Bladder Treated with Sacral Neuromodulation","volume":"199","author":"Siegel","year":"2018","journal-title":"J. Urol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/nau.22609","article-title":"Do We Need a New Definition of the Overactive Bladder Syndrome? ICI-RS 2013","volume":"33","author":"Drake","year":"2014","journal-title":"Neurourol. Urodyn."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1046\/j.1464-410x.2001.02228.x","article-title":"How Widespread Are the Symptoms of an Overactive Bladder and How Are They Managed? A Population-Based Prevalence Study","volume":"87","author":"Milsom","year":"2001","journal-title":"BJU Int."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1111\/j.1464-410X.2008.07601.x","article-title":"The Impact of Overactive Bladder, Incontinence and Other Lower Urinary Tract Symptoms on Quality of Life, Work Productivity, Sexuality and Emotional Well-Being in Men and Women: Results from the EPIC Study","volume":"101","author":"Coyne","year":"2008","journal-title":"BJU Int."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1097\/JU.0000000000000309","article-title":"Diagnosis and Treatment of Overactive Bladder (Non-Neurogenic) in Adults: AUA\/SUFU Guideline Amendment 2019","volume":"202","author":"Lightner","year":"2019","journal-title":"J. Urol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/S0022-5347(05)67558-1","article-title":"Sacral Neuromodulation in the Treatment of Urgency-Frequency Symptoms: A Multicenter Study on Efficacy and Safety","volume":"163","author":"Hassouna","year":"2000","journal-title":"J. Urol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0090-4295(00)00597-5","article-title":"Long-Term Results of a Multicenter Study on Sacral Nerve Stimulation for Treatment of Urinary Urge Incontinence, Urgency-Frequency, and Retention","volume":"56","author":"Siegel","year":"2000","journal-title":"Urology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0022-5347(05)68558-8","article-title":"Sacral Nerve Stimulation for Treatment of Refractory Urinary Urge Incontinence. Sacral Nerve Stimulation Study Group","volume":"162","author":"Schmidt","year":"1999","journal-title":"J. Urol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1001\/jama.2016.14617","article-title":"OnabotulinumtoxinA vs Sacral Neuromodulation on Refractory Urgency Urinary Incontinence in Women: A Randomized Clinical Trial","volume":"316","author":"Amundsen","year":"2016","journal-title":"JAMA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/j.juro.2007.07.032","article-title":"Results of Sacral Neuromodulation Therapy for Urinary Voiding Dysfunction: Outcomes of a Prospective, Worldwide Clinical Study","volume":"178","author":"Heesakkers","year":"2007","journal-title":"J. Urol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/00005392-200101000-00004","article-title":"Efficacy of Sacral Nerve Stimulation for Urinary Retention: Results 18 Months after Implantation","volume":"165","author":"Jonas","year":"2001","journal-title":"J. Urol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1464-410X.2006.06508.x","article-title":"Medium-Term Experience of Sacral Neuromodulation by Tined Lead Implantation","volume":"99","author":"Oerlemans","year":"2007","journal-title":"BJU Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/nau.24694","article-title":"Efficacy of Sacral Neuromodulation and Percutaneous Tibial Nerve Stimulation in the Treatment of Chronic Nonobstructive Urinary Retention: A Systematic Review","volume":"40","author":"Ho","year":"2021","journal-title":"Neurourol. Urodyn."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1525-1403.2012.00465.x","article-title":"Does Sacral Neuromodulation Lead to Relevant Reduction in the Need for Intermittent Catheterization? A Single-Center Experience on Patients with Chronic Urinary Retention","volume":"15","author":"Denzinger","year":"2012","journal-title":"Neuromodulation"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/S0022-5347(05)66551-2","article-title":"Percutaneous Sacral Nerve Root Neuromodulation for Intractable Interstitial Cystitis","volume":"165","author":"Maher","year":"2001","journal-title":"J. Urol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1111\/j.1464-410X.2010.09697.x","article-title":"The Long-Term Efficacy of Sacral Neuromodulation in the Management of Intractable Cases of Bladder Pain Syndrome: 14 Years of Experience in One Centre","volume":"107","author":"Gajewski","year":"2011","journal-title":"BJU Int."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s00192-010-1281-3","article-title":"Sacral Neuromodulation Stimulation for IC\/PBS, Chronic Pelvic Pain, and Sexual Dysfunction","volume":"21","author":"Fariello","year":"2010","journal-title":"Int. Urogynecol. J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.eururo.2017.11.002","article-title":"Efficacy and Safety of Sacral and Percutaneous Tibial Neuromodulation in Non-Neurogenic Lower Urinary Tract Dysfunction and Chronic Pelvic Pain: A Systematic Review of the Literature","volume":"73","author":"Tutolo","year":"2018","journal-title":"Eur. Urol."},{"key":"ref_46","unstructured":"EAU Guidelines (2024, February 16). Neuro-Urology. Available online: https:\/\/uroweb.org\/guidelines\/neuro-urology\/chapter\/introduction."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.urology.2020.06.063","article-title":"Sacral Nerve Stimulation in Parkinson\u2019s Disease Patients with Overactive Bladder Symptoms","volume":"144","author":"Greenberg","year":"2020","journal-title":"Urology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1007\/s00345-015-1479-6","article-title":"The Value of Urodynamic Tools to Guide Patient Selection in Sacral Neuromodulation","volume":"33","author":"Drossaerts","year":"2015","journal-title":"World J. Urol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1159\/000501529","article-title":"Sacral Neuromodulation for Lower Urinary Tract Dysfunction in Spinal Cord Injury: A Systematic Review and Meta-Analysis","volume":"103","author":"Hu","year":"2019","journal-title":"Urol. Int."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00345-011-0669-0","article-title":"Sacral Neuromodulation in Patients with Multiple Sclerosis","volume":"30","author":"Minardi","year":"2012","journal-title":"World J. Urol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00192-015-2771-0","article-title":"Sacral Neuromodulation: An Effective Treatment for Lower Urinary Tract Symptoms in Multiple Sclerosis","volume":"27","author":"Puccini","year":"2016","journal-title":"Int. Urogynecol. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.urology.2020.11.075","article-title":"The Effect of Sacral Neuromodulation in Ambulatory Spina Bifida Patients with Neurogenic Bladder and Bowel Dysfunction","volume":"153","author":"Chen","year":"2021","journal-title":"Urology"},{"key":"ref_53","first-page":"1374","article-title":"Effectiveness and safety of sacral neuromodulation on neurogenic bladder and bowel dysfunction in patients with spina bifida","volume":"35","author":"Chen","year":"2021","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1007\/s12325-021-01650-9","article-title":"Systematic Literature Review and Meta-Analysis of Sacral Neuromodulation (SNM) in Patients with Neurogenic Lower Urinary Tract Dysfunction (nLUTD): Over 20 Years\u2019 Experience and Future Directions","volume":"38","author":"Engelberg","year":"2021","journal-title":"Adv. Ther."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.urology.2020.06.023","article-title":"Sacral Neuromodulation: Determining Predictors of Success","volume":"153","author":"Morgan","year":"2021","journal-title":"Urology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.juro.2017.01.037","article-title":"Urinary Biomarkers in Women with Refractory Urgency Urinary Incontinence Randomized to Sacral Neuromodulation versus OnabotulinumtoxinA Compared to Controls","volume":"197","author":"Richter","year":"2017","journal-title":"J. Urol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/nau.21037","article-title":"Efficacy of Sacral Neuromodulation in Treatment of Bladder Pain Syndrome: Long-Term Follow-Up","volume":"30","author":"Ghazwani","year":"2011","journal-title":"Neurourol. Urodyn."},{"key":"ref_58","first-page":"E7","article-title":"Sacral Neuromodulation Using the Standardized Tined Lead Implantation Technique with a Curved vs a Straight Stylet: 2-Year Clinical Outcomes and Sensory Responses to Lead Stimulation","volume":"123","author":"Kessler","year":"2019","journal-title":"BJU Int."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/nau.22437","article-title":"Randomized Prospective Crossover Study of Interstim Lead Wire Placement with Curved versus Straight Stylet","volume":"33","author":"Jacobs","year":"2014","journal-title":"Neurourol. Urodyn."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/bju.14240","article-title":"Improving Clinical Outcomes for Women with Overactive Bladder or Urinary Retention Symptoms: A Comparison of Motor Response Voltages (1\u20139 V) during Stage 1 Sacral Neuromodulation","volume":"122","author":"Marinkovic","year":"2018","journal-title":"BJU Int."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000020134","article-title":"Sacral Root Neuromodulation in the Treatment of Refractory Urinary Urge Incontinence: A Prospective Randomized Clinical Trial","volume":"37","author":"Weil","year":"2000","journal-title":"Eur. Urol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1159\/000049812","article-title":"Buttock Placement of the Implantable Pulse Generator: A New Implantation Technique for Sacral Neuromodulation\u2014A Multicenter Study","volume":"40","author":"Scheepens","year":"2001","journal-title":"Eur. Urol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s001920070031","article-title":"Patient Satisfaction and Complications Following Sacral Nerve Stimulation for Urinary Retention, Urge Incontinence and Perineal Pain: A Multicenter Evaluation","volume":"11","author":"Everaert","year":"2000","journal-title":"Int. Urogynecol. J. Pelvic. Floor Dysfunct."},{"key":"ref_64","first-page":"14","article-title":"Permanente Sakrale Neuromodulation Mittels InterStim1: Ergebnisse Einer Anwenderbefragung Zu Aktuellen Technischen Entwicklungen","volume":"14","author":"Sievert","year":"2007","journal-title":"J. Urol. Urogynakol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1016\/S0022-5347(06)00318-1","article-title":"Failure of Sacral Nerve Stimulation Due to Migration of Tined Lead","volume":"175","author":"Deng","year":"2006","journal-title":"J. Urol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s11934-012-0268-7","article-title":"Troubleshooting Sacral Neuromodulation Issues","volume":"13","author":"Carmel","year":"2012","journal-title":"Curr. Urol. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1464-410X.2004.04979.x","article-title":"Long-Term Results of Sacral Neuromodulation for Women with Urinary Retention","volume":"94","author":"Dasgupta","year":"2004","journal-title":"BJU Int."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e851","DOI":"10.1016\/j.juro.2016.02.1112","article-title":"PD36-07 Infection rate after sacral neuromodulation surgery: A review of 1033 interstim procedures","volume":"195","author":"Clifton","year":"2016","journal-title":"J. Urol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s11605-010-1177-z","article-title":"Infection Rates in a Large Investigational Trial of Sacral Nerve Stimulation for Fecal Incontinence","volume":"14","author":"Wexner","year":"2010","journal-title":"J. Gastrointest. Surg."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/ner.13255","article-title":"Stimulation Parameters for Sacral Neuromodulation on Lower Urinary Tract and Bowel Dysfunction-Related Clinical Outcome: A Systematic Review","volume":"23","author":"Assmann","year":"2020","journal-title":"Neuromodulation"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"123","DOI":"10.7257\/1053-816X.2016.36.3.123","article-title":"Cycling versus Continuous Mode in Neuromodulator Programming: A Crossover, Randomized, Controlled Trial","volume":"36","author":"Beer","year":"2016","journal-title":"Urol. Nurs."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/nau.22962","article-title":"Stimulation Latency and Comparison of Cycling Regimens in Women Using Sacral Neuromodulation","volume":"36","author":"Cadish","year":"2017","journal-title":"Neurourol. Urodyn."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/nau.22938","article-title":"Intermittent Sacral Neuromodulation for Idiopathic Urgency Urinary Incontinence in Women","volume":"36","author":"Groen","year":"2017","journal-title":"Neurourol. Urodyn."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1002\/nau.24476","article-title":"Unilateral versus Bilateral Sacral Neuromodulation Test in the Treatment of Refractory Idiopathic Overactive Bladder: A Randomized Controlled Pilot Trial","volume":"39","author":"Wagner","year":"2020","journal-title":"Neurourol. Urodyn."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.juro.2010.10.065","article-title":"The Use of Bilateral Sacral Nerve Stimulation in Patients with Loss of Unilateral Treatment Efficacy","volume":"185","author":"Marcelissen","year":"2011","journal-title":"J. Urol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1016\/S0022-5347(05)64292-9","article-title":"Unilateral versus Bilateral Sacral Neuromodulation in Patients with Chronic Voiding Dysfunction","volume":"168","author":"Scheepens","year":"2002","journal-title":"J. Urol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00345-011-0780-2","article-title":"Sacral Neuromodulation for Lower Urinary Tract Dysfunction","volume":"30","author":"Marcelissen","year":"2012","journal-title":"World J. Urol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s11934-010-0132-6","article-title":"Sacral Nerve Modulation in Overactive Bladder","volume":"11","author":"Occhino","year":"2010","journal-title":"Curr. Urol. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e196","DOI":"10.1111\/j.1463-1318.2011.02646.x","article-title":"Sacral Nerve Stimulation for Faecal Incontinence: Optimizing Outcome and Managing Complications","volume":"13","author":"Dudding","year":"2011","journal-title":"Color. Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1111\/j.1463-1318.2011.02650.x","article-title":"Sacral Nerve Stimulation for Faecal Incontinence: Patient Selection, Service Provision and Operative Technique","volume":"13","author":"Dudding","year":"2011","journal-title":"Color. Dis."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/ner.13117","article-title":"European SNM Expert Group Programming Algorithms for Sacral Neuromodulation: Clinical Practice and Evidence-Recommendations for Day-to-Day Practice","volume":"23","author":"Lehur","year":"2020","journal-title":"Neuromodulation"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.surge.2014.11.002","article-title":"A Review of Sacral Nerve Stimulation Parameters Used in the Treatment of Faecal Incontinence","volume":"13","author":"Devane","year":"2015","journal-title":"Surgeon"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/ner.12695","article-title":"Sacral Neuromodulation: Standardized Electrode Placement Technique","volume":"20","author":"Matzel","year":"2017","journal-title":"Neuromodulation"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s11934-011-0204-2","article-title":"How Does Sacral Modulation Work Best? Placement and Programming Techniques to Maximize Efficacy","volume":"12","author":"Amend","year":"2011","journal-title":"Curr. Urol. Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/MOU.0000000000000294","article-title":"Neuromodulation and Female Pelvic Disorders","volume":"26","author":"Noblett","year":"2016","journal-title":"Curr. Opin. Urol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.juro.2010.12.089","article-title":"The Effect of Pulse Rate Changes on the Clinical Outcome of Sacral Neuromodulation","volume":"185","author":"Marcelissen","year":"2011","journal-title":"J. Urol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Hamani, C., Holtzheimer, P., Lozano, A.M., and Mayberg, H. (2015). Neuromodulation in Psychiatry, Wiley.","DOI":"10.1002\/9781118801086"},{"key":"ref_88","first-page":"2303","article-title":"Parameters of Successful Sacral Root Neuromodulation of the Pelvic Floor: A Retrospective Study","volume":"11","author":"Mahfooz","year":"2004","journal-title":"Can. J. Urol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"S284","DOI":"10.1002\/mds.20961","article-title":"Basic Algorithms for the Programming of Deep Brain Stimulation in Parkinson\u2019s Disease","volume":"21","author":"Volkmann","year":"2006","journal-title":"Mov. 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