{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:57:55Z","timestamp":1760144275523,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T00:00:00Z","timestamp":1711238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Ectodermal dysplasia (ED)\u2014a genetic disorder\u2014is characterized by severe tooth deficiency. We compared the mandibular volume and the sagittal and horizontal mandibular widths between patients with ED (ED group) and individuals without tooth deficiency (control group) using three-dimensional modeling. We hypothesized that the mandibular volume differs in ED cases owing to congenital tooth deficiency. Materials and Methods: We used previously obtained cone-beam computed tomography (CBCT) images of 13 patients with ED. The control group data comprised retrospective CBCT images of patients of similar age and sex with a skeletal relationship of class 1. Further, using the three-dimensional image analysis software, the tooth crowns were separated from the mandible, the mandible was reconstructed and the gonion-to-gonion distance in the mandible was marked, the distance to the menton point was measured, and the distance between the two condyles was measured and compared with the control group. Results: Overall, 46.2% and 53.8% of the participants were men and women, respectively. In the ED group, the mean age of the participants was 15.46 (range, 6\u201324) years, and the mean number of mandibular teeth was 4.62. Notably, the edentulous mandible volume of the ED group (27.020 mm3) was statistically significantly smaller than that of the control group (49.213 mm3) (p &lt; 0.001). There was no difference between the two groups in terms of the marked points. For data analysis, the Shapiro\u2013Wilk test, independent samples t-test, and Mann\u2013Whitney U test were used. Conclusions: It has been considered that mandible volume does not develop in ED cases because of missing teeth. Modern practices, such as the CBCT technique and three-dimensional software, may be effective in identifying the true morphologic features, especially in patients with genetic syndromes affecting the maxillofacial structure.<\/jats:p>","DOI":"10.3390\/medicina60040528","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T12:47:11Z","timestamp":1711370831000},"page":"528","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Three-Dimensional Modeling and Quantitative Assessment of Mandibular Volume in Ectodermal Dysplasia: A Case Series"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4302-6561","authenticated-orcid":false,"given":"Ebru","family":"Akleyin","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Faculty of Dentistry, Dicle University, Diyarbak\u0131r 21010, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasemin","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Faculty of Dentistry, Harran University, Urfa 63000, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2776-1195","authenticated-orcid":false,"given":"Ahmet","family":"Yard\u0131meden","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Faculty of Engineering, Dicle University, Diyarbak\u0131r 21010, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4103\/0970-0358.63969","article-title":"Ectodermal dysplasia-maxillary and mandibular alveolar reconstruction with dental rehabilitation: A case report and review of the literature","volume":"43","author":"Deshpande","year":"2010","journal-title":"Indian J. Plast. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1607-551X(09)70303-1","article-title":"Evaluation of ectodermal dysplasia","volume":"22","author":"Baskan","year":"2006","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_3","first-page":"268","article-title":"Dental implants in patients with ectodermal dysplasia and tooth agenesis: A critical review of the literature","volume":"22","author":"Yap","year":"2009","journal-title":"Int. J. Prosthodont."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ajmg.1320530207","article-title":"Ectodermal dysplasias: A clinical classification and a causal review","volume":"53","author":"Pinheiro","year":"1994","journal-title":"Am. J. Med. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5577\/intdentres.2022.vol12.no1.4","article-title":"Ectodermal dysplasia: A retrospective evaluation of the clinical findings of forty-four cases in the 0\u201316 years age","volume":"12","author":"Akleyin","year":"2022","journal-title":"Int. Dent. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-263X.2005.00610.x","article-title":"Treatment outcomes for adolescent ectodermal dysplasia patients treated with dental implants","volume":"15","author":"Sweeney","year":"2005","journal-title":"Int. J. Paediatr. Dent."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.ijom.2016.03.011","article-title":"Clinical outcomes of implant therapy in ectodermal dysplasia patients: A systematic review","volume":"4\u20135","author":"Wang","year":"2016","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.jcms.2018.05.038","article-title":"Dental implants in patients with ectodermal dysplasia: A systematic review","volume":"46","author":"Chrcanovic","year":"2018","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e20190148","DOI":"10.1590\/1678-7757-2019-0148","article-title":"CBCT assessment of bone thickness in maxillary and mandibular teeth: An anatomic study","volume":"28","author":"Porto","year":"2020","journal-title":"J. Appl. Oral Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/RCT.0000000000000166","article-title":"Relationship between the position of the mental foramen and the anterior loop of the inferior alveolar nerve as determined by cone beam computed tomography combined with mimics","volume":"39","author":"Chen","year":"2015","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Lo Giudice, A., Ronsivalle, V., Grippaudo, C., Lucchese, A., Muraglie, S., Lagrav\u00e8re, M.O., and Isola, G. (2020). One step before 3D printing\u2014Evaluation of imaging software accuracy for 3-dimensional analysis of the mandible: A comparative study using a surface-to-surface matching technique. Materials, 13.","DOI":"10.3390\/ma13122798"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"540.e1","DOI":"10.1016\/j.ajodo.2010.04.025","article-title":"Three-dimensional computed tomography analysis of mandibular morphology in patients with facial asymmetry and mandibular prognathism","volume":"138","author":"You","year":"2010","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_13","unstructured":"Moyers, R.E. (1973). Handbook of Orthodontics for the Student and General Practitioner, Year Book Medical Publish."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2319\/012913-87.1","article-title":"Evaluation of mandibular volume using cone-beam computed tomography and correlation with cephalometric values","volume":"84","author":"Katayama","year":"2014","journal-title":"Angle Orthod."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"966","DOI":"10.2319\/022011-122.1","article-title":"Mandibular asymmetry in unilateral and bilateral posterior crossbite patients using cone-beam computed tomography","volume":"81","author":"Veli","year":"2011","journal-title":"Angle Orthod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ajodo.2008.02.029","article-title":"Morphologic quantification of the maxilla and the mandible with cone-beam computed tomography","volume":"137","author":"Deguchi","year":"2010","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_17","first-page":"865","article-title":"Craniomaxillofacial morphology by X-ray computed tomography","volume":"75","author":"Hashiba","year":"1987","journal-title":"Shigaku"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"885e","DOI":"10.1097\/PRS.0000000000001160","article-title":"Reduced three-dimensional nasal airway volume in Treacher Collins syndrome and its association with craniofacial morphology","volume":"135","author":"Ma","year":"2015","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4103\/0976-9668.117012","article-title":"Hereditary ectodermal dysplasia: A retrospective study","volume":"4","author":"More","year":"2013","journal-title":"J. Nat. Sci. Biol. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.arcmed.2005.06.016","article-title":"Ectodermal dysplasia: Retrospective study of fifteen cases","volume":"37","author":"Yavuz","year":"2006","journal-title":"Arch. Med. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1034\/j.1600-0544.2002.01159.x","article-title":"Analysis of facial growth in subjects with syndromic ectodermal dysplasia: A longitudinal analysis","volume":"5","author":"Bondarets","year":"2002","journal-title":"Orthod. Craniofac. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.archoralbio.2017.02.020","article-title":"Patterns of non-syndromic permanent tooth agenesis in a large orthodontic population","volume":"79","author":"Gkantidis","year":"2017","journal-title":"Arch. Oral Biol."},{"key":"ref_23","first-page":"175","article-title":"Wolff\u2019s law and bone\u2019s structural adaptations to mechanical usage: An overview for clinicians","volume":"64","author":"Frost","year":"1994","journal-title":"Angle Orthod."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3109\/00016356609026127","article-title":"The reduction in face height of edentulous and partially edentulous subjects during long-term denture wear a longitudinal roentgenographic cephalometric STUDY","volume":"24","author":"Tallgren","year":"1966","journal-title":"Acta Odontol. Scand."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/ajmg.10654","article-title":"Analysis of craniofacial development in children with hypohidrotic ectodermal dysplasia","volume":"112","author":"Johnson","year":"2002","journal-title":"Am. J. Med. Genet."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1365-2842.2005.01566.x","article-title":"Growth analysis of a patient with ectodermal dysplasia treated with endosseous implants: 6-year follow-up","volume":"33","author":"Alcan","year":"2006","journal-title":"J. Oral Rehabil."},{"key":"ref_27","first-page":"6691235","article-title":"Comprehensive management of ectodermal dysplasia with interceptive orthodontics in a young boy who was bullied at school","volume":"2020","author":"Wimalarathna","year":"2020","journal-title":"Case Rep. Dent."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1600-0722.2008.00550.x","article-title":"Non-invasive longitudinal assessment of facial growth in children and adolescents with hypohidrotic ectodermal dysplasia","volume":"116","author":"Dellavia","year":"2008","journal-title":"Eur. J. Oral Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-263X.1993.tb00044.x","article-title":"Longitudinal study of jaw growth and prosthetic management in a patient with ectodermal dysplasia and anodontia","volume":"3","author":"Nomura","year":"1993","journal-title":"Int. J. Paediatr. Dent."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1080\/13102818.2022.2138782","article-title":"Reasons for requesting cone-beam computed tomography in children and adolescents: A 10-year study","volume":"36","author":"Akleyin","year":"2022","journal-title":"Biotechnol. Biotechnol. Equip."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/4\/528\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:17:49Z","timestamp":1760105869000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/4\/528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,24]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["medicina60040528"],"URL":"https:\/\/doi.org\/10.3390\/medicina60040528","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2024,3,24]]}}}