{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:36:43Z","timestamp":1783424203652,"version":"3.54.6"},"reference-count":74,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Atrial fibrillation (AF) is an important independent risk factor for stroke. Current guidelines handle AF as a binary entity with risk driven by the presence of clinical risk factors, which guides the decision to treat with an oral anticoagulant. Recent studies in the literature suggest a dose\u2013response relationship between AF burden and stroke risk, in both clinical AF and subclinical atrial fibrillation (SCAF), which differs from current guidance to disregard burden and utilize clinical risk scores alone. Within clinical classification and at the same risk levels in various scores, the risk of stroke increases with AF burden. This opens the possibility of incorporating burden into risk profiles, which has already shown promise. Long-term rhythm monitoring is needed to elucidate SCAF in patients with stroke. Recent data from randomized trials are controversial regarding whether there is an independent risk from AF episodes with a duration of less than 24 h, including the duration of SCAF greater than six minutes but less than 24 h.<\/jats:p>","DOI":"10.3390\/medicina60040536","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T11:34:58Z","timestamp":1711452898000},"page":"536","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Atrial Fibrillation Burden: Impact on Stroke Risk and Beyond"],"prefix":"10.3390","volume":"60","author":[{"given":"Ahmed","family":"AlTurki","sequence":"first","affiliation":[{"name":"Division of Cardiology, McGill University Health Center, Montreal, QC H3G1A4, Canada"},{"name":"Department of Medicine, Faculty of Medicine, Kuwait University, Jabriya 13110, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidal","family":"Essebag","sequence":"additional","affiliation":[{"name":"Division of Cardiology, McGill University Health Center, Montreal, QC H3G1A4, Canada"},{"name":"Division of Cardiology, Hopital Sacre-Coeur de Montreal, Montreal, QC H4J 1C5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1056\/NEJMcp2023658","article-title":"Atrial Fibrillation","volume":"384","author":"Michaud","year":"2021","journal-title":"New Engl. 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