{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T02:58:12Z","timestamp":1782788292638,"version":"3.54.5"},"reference-count":62,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background: Chemotherapy-induced cardiac dysfunction (CIC) is a significant and concerning complication observed among cancer patients. Despite the demonstrated cardioprotective benefits of statins in various cardiovascular diseases, their effectiveness in mitigating CIC remains uncertain. Objective: This meta-analysis aims to comprehensively evaluate the potential cardioprotective role of statins in patients with CIC. Methods: A systematic literature search was conducted using PubMed, Embase, and Scopus databases to identify relevant articles published from inception until 10th May 2023. The outcomes were assessed using pooled odds ratio (OR) for categorical data and mean difference (MD) for continuous data, with corresponding 95% confidence intervals (95% CIs). Results: This meta-analysis comprised nine studies involving a total of 5532 patients, with 1904 in the statin group and 3628 in the non-statin group. The pooled analysis of primary outcome shows that patients who did not receive statin suffer a greater decline in the LVEF after chemotherapy compared to those who receive statin (MD, 3.55 (95% CI: 1.04\u20136.05), p = 0.01). Likewise, we observed a significantly higher final mean LVEF among chemotherapy patients with statin compared to the non-statin group of patients (MD, 2.08 (95% CI: 0.86\u20133.30), p &gt; 0.001). Additionally, there was a lower risk of incident heart failure in the statin group compared to the non-statin group of patients (OR, 0.41 (95% CI: 0.27\u20130.62), p &lt; 0.001). Lastly, the change in the mean difference for LVEDV was not statistically significant between the statin and non-statin groups (MD, 1.55 (95% CI: \u22125.22\u20138.33), p = 0.65). Conclusion: Among patients of CIC, statin use has shown cardioprotective benefits by improving left ventricular function and reducing the risk of heart failure.<\/jats:p>","DOI":"10.3390\/medicina60040580","type":"journal-article","created":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T13:44:52Z","timestamp":1711892692000},"page":"580","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association between Statin Use and Chemotherapy-Induced Cardiotoxicity: A Meta-Analysis"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2021-1660","authenticated-orcid":false,"given":"Vikash","family":"Jaiswal","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Research, Larkin Community Hospital, South Miami, FL 33143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8557-9880","authenticated-orcid":false,"given":"Song Peng","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rutgers Health\/Community Medical Center, Toms River, NJ 08755, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9005-8358","authenticated-orcid":false,"given":"Novonil","family":"Deb","sequence":"additional","affiliation":[{"name":"North Bengal Medical College and Hospital, Darjeeling 734012, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Hanif","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, SUNY Upstate Medical University, 750 E Adams St., Syracuse, NY 13210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitya","family":"Batra","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Beaumont Hospital, Royal Oak, MI 48073, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Gautham","family":"Kanagala","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Metropolitan Hospital Center, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7238-1058","authenticated-orcid":false,"given":"Nikhil","family":"Vojjala","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Trinity Health Oakland\/Wayne State University, Detroit, MI 48341, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kripa","family":"Rajak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, UPMC Harrisburgh, 111 S Front St., Harrisburg, PA 17101, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5636-0334","authenticated-orcid":false,"given":"Poulami","family":"Roy","sequence":"additional","affiliation":[{"name":"North Bengal Medical College and Hospital, Darjeeling 734012, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5151-1615","authenticated-orcid":false,"given":"Medha","family":"Sharath","sequence":"additional","affiliation":[{"name":"Bangalore Medical College and Research Institute, Kalasipalya, Bengaluru 560002, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeeha Subhan","family":"Waleed","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Lower Bucks Hospital, Bristo, 501 Bath Rd., Bristol, PA 19007, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zarghoona","family":"Wajid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wayne State University School of Medicine, 540 E. Canfield Ave., Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6359-3435","authenticated-orcid":false,"given":"Jishanth","family":"Mattumpuram","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,31]]},"reference":[{"key":"ref_1","unstructured":"(2024, January 27). Cancer Facts & Figures 2022. Available online: https:\/\/www.cancer.org\/research\/cancer-facts-statistics\/all-cancer-facts-figures\/cancer-facts-figures-2022.html."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer Statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. 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