{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:46:19Z","timestamp":1778262379533,"version":"3.51.4"},"reference-count":23,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T00:00:00Z","timestamp":1712361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Parkinson\u2019s disease (PD) is associated with various non-motor symptoms, including minor hallucinations, comprising visual illusions and presence and passage hallucinations. Despite their occurrence, even in newly diagnosed PD patients, data regarding the prevalence and characteristics of minor hallucinations, visual illusions in particular, remain limited. The aim of this study was to address this knowledge gap by assessing the prevalence of minor hallucinations in PD patients, with a focus on visual illusions. Materials and Methods: In this prospective pilot study, we enrolled 35 PD patients without dementia and 35 age- and gender-matched PD-unaffected individuals. Cognitive function was assessed using the Montreal Cognitive Assessment, clinical data were collected, and all subjects were assessed via questionnaires regarding 20 types of visual illusions and other minor hallucinations. Results: The prevalence of minor hallucinations was significantly higher among PD patients compared to controls (45.7% vs. 11.4%, p = 0.003). PD patients reported visual illusions and presence hallucinations more frequently than the controls (37.1% vs. 8.6% and 22.9% vs. 2.9%, p = 0.009 and p = 0.028, respectively), with no significant difference in passage hallucinations (20% vs. 8.6%, p = 0.306). In the PD group, the most frequently observed visual illusions were complex visual illusions, kinetopsia, and pelopsia; the latter was also the most common visual illusion in the control group. PD patients experiencing visual illusions were more likely to report presence hallucinations compared to patients without visual illusions (53.8% vs. 4.5%, p = 0.002); no significant differences in other clinical characteristics were found. Conclusions: Minor hallucinations are a common phenomenon among PD patients without dementia, with a higher prevalence than among healthy controls. Visual illusions are the most prevalent type of minor hallucinations, affecting more than a third of PD patients, with complex visual illusions, kinetopsia, and pelopsia being the most frequently reported types.<\/jats:p>","DOI":"10.3390\/medicina60040606","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T12:01:22Z","timestamp":1712577682000},"page":"606","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exploring the Spectrum of Visual Illusions and Other Minor Hallucinations in Patients with Parkinson\u2019s Disease in Lithuania"],"prefix":"10.3390","volume":"60","author":[{"given":"Neringa","family":"Jucevi\u010di\u016bt\u0117","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus Str. 9, LT-44307 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Balnyt\u0117","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus Str. 9, LT-44307 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ovidijus","family":"Laucius","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus Str. 9, LT-44307 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/mds.21875","article-title":"Scales to assess psychosis in Parkinson\u2019s disease: Critique and recommendations","volume":"23","author":"Fernandez","year":"2008","journal-title":"Mov. Disord."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1212\/WNL.43.11.2227","article-title":"Risk factors for nursing home placement in advanced Parkinson\u2019s disease","volume":"43","author":"Goetz","year":"1993","journal-title":"Neurology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.1532-5415.2000.tb06891.x","article-title":"Predictors of nursing home placement in Parkinson\u2019s disease: A population-based, prospective study","volume":"48","author":"Aarsland","year":"2000","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_5","first-page":"100119","article-title":"High frequency of psychosis in late-stage Parkinso\u0144s disease","volume":"5","author":"Chendo","year":"2021","journal-title":"Clin. Park. Relat. Disord."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/mds.21382","article-title":"Diagnostic criteria for psychosis in Parkinson\u2019s disease: Report of an NINDS, NIMH work group","volume":"22","author":"Ravina","year":"2007","journal-title":"Mov. Disord."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/mds.26432","article-title":"Minor hallucinations occur in drug-naive Parkinson\u2019s disease patients, even from the premotor phase","volume":"31","author":"Pagonabarraga","year":"2016","journal-title":"Mov. Disord."},{"key":"ref_8","first-page":"154","article-title":"Disturbances of visual perception in non-demented patients with Parkinson\u2019s disease","volume":"23","author":"Vilda","year":"2019","journal-title":"Neurol. Semin."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/psyg.12771","article-title":"Visual illusions in Parkinson\u2019s disease: An interview survey of symptomatology","volume":"22","author":"Sasaki","year":"2022","journal-title":"Psychogeriatrics"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1212\/WNL.40.10.1529","article-title":"Variable expression of Parkinson\u2019s disease","volume":"40","author":"Jankovic","year":"1990","journal-title":"Neurology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3469706","DOI":"10.1155\/2021\/3469706","article-title":"Prevalence and Risk Factors for Minor Hallucinations in Patients with Parkinson\u2019s Disease","volume":"2021","author":"Zhong","year":"2021","journal-title":"Behav. Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.parkreldis.2018.05.023","article-title":"Defining visual illusions in Parkinson\u2019s disease: Kinetopsia and object misidentification illusions","volume":"55","author":"Nishio","year":"2018","journal-title":"Park. Relat. Disord."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3389\/fnhum.2019.00269","article-title":"Origins Matter: Culture Impacts Cognitive Testing in Parkinson\u2019s Disease","volume":"13","author":"Statucka","year":"2019","journal-title":"Front. Hum. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/ane.13380","article-title":"Risk factors for minor hallucinations in Parkinson\u2019s disease","volume":"143","author":"Omoto","year":"2021","journal-title":"Acta Neurol. Scand."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1007\/s00415-020-09925-x","article-title":"Visual hallucinations and illusions in Parkinson\u2019s disease: The role of ocular pathology","volume":"267","author":"Marques","year":"2020","journal-title":"J. Neurol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrneurol.2016.200","article-title":"The psychosis spectrum in Parkinson disease","volume":"13","author":"Ffytche","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/mds.20308","article-title":"Repeated visual hallucinations in Parkinson\u2019s disease as disturbed external\/internal perceptions: Focused review and a new integrative model","volume":"20","author":"Diederich","year":"2005","journal-title":"Mov. Disord."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.neubiorev.2007.09.004","article-title":"The possible role of retinal dopaminergic system in visual performance","volume":"32","author":"Brandies","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1158188","DOI":"10.3389\/fneur.2023.1158188","article-title":"Clinical features of minor hallucinations in different phenotypes of Parkinson\u2019s disease: A cross-sectional study","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1212\/WNL.0000000000007913","article-title":"Minor hallucinations in Parkinson disease","volume":"93","author":"Lenka","year":"2019","journal-title":"Neurology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1007\/s00415-022-11074-2","article-title":"Two-year longitudinal follow-up of visual illusions and hallucinations in Parkinson\u2019s disease","volume":"269","author":"Beze","year":"2022","journal-title":"J. Neurol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/mds.29681","article-title":"Functional Brain Networks of Minor and Well-Structured Major Hallucinations in Parkinson\u2019s Disease","volume":"39","author":"Baik","year":"2024","journal-title":"Mov. Disord."},{"key":"ref_23","first-page":"438","article-title":"Minor hallucinations reflect early gray matter loss and predict subjective cognitive decline in Parkinson\u2019s disease","volume":"28","author":"Sampedro","year":"2020","journal-title":"Eur. J. Neurol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/4\/606\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:24:09Z","timestamp":1760106249000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/4\/606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,6]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["medicina60040606"],"URL":"https:\/\/doi.org\/10.3390\/medicina60040606","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,6]]}}}