{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T23:26:16Z","timestamp":1793057176045,"version":"4.5.0"},"reference-count":54,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: The association between endometriosis and breast cancer still remains controversial. The aim of this study was to investigate the different subtypes of breast cancer, immunohistochemical markers, hormone receptors, and ki67 proliferation indexes in patients with and without endometriosis and\/or adenomyosis. Materials and Methods: All patients with endometriosis and breast cancer were enrolled. Women with endometriosis and breast cancer (Group BC+EN+) were compared to patients with breast cancer without endometriosis (group BC+EN\u2212) and those with endometriosis without breast cancer (group BC-EN+). General population characteristics and histological and immunohistochemical subtypes of breast cancer were compared between groups. Results: Our study included 41 cases affected by both endometriosis and\/or adenomyosis and breast cancer (Group BC+EN+) that were matched (1:2) with 82 patients affected only by breast cancer (group BC+EN\u2212) and 82 patients affected only by endometriosis and\/or adenomyosis (group BC-EN+). Group BC+EN+ presented a higher percentage of ER receptor expression (83% vs. 70%, p = 0.02), as well as lower values of Ki 67% (15% vs. 24%, p &lt; 0.0001) and HER2+ (9.8% vs. 28%, p = 0.022). These findings were more evident when comparing patients with premenopausal status, while in postmenopausal patients, this difference was no longer significant. Regarding endometriosis, no statistical differences were observed in type or specific localization of the disease among the groups with and without breast cancer. Conclusions: Patients with endometriosis presented lower aggressive breast cancer rates with higher values of ER% and lower values of Ki 67 and HER2neu+. The type and severity of endometriotic diseases seemed not to influence breast cancer occurrence.<\/jats:p>","DOI":"10.3390\/medicina60040625","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T11:09:20Z","timestamp":1712920160000},"page":"625","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Breast Cancer in Patients with Previous Endometriosis Showed Low Aggressive Subtype"],"prefix":"10.3390","volume":"60","author":[{"given":"Gianluca","family":"Vanni","sequence":"first","affiliation":[{"name":"Breast Unit, Department of Surgical Science, University of Rome \u201cTor Vergata\u201d, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2467-737X","authenticated-orcid":false,"given":"Aikaterini","family":"Selntigia","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecological Unit, Department of Surgical Science, University of Rome \u201cTor Vergata\u201d, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6604-1473","authenticated-orcid":false,"given":"Valentina Enrica","family":"Marsella","sequence":"additional","affiliation":[{"name":"Breast Unit, Department of Surgical Science, University of Rome \u201cTor Vergata\u201d, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Russo","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecological Unit, Department of Surgical Science, University of Rome \u201cTor Vergata\u201d, Viale Oxford 81, 00133 Rome, Italy"},{"name":"Ph.D. Program in Translation Medicine, Department Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pellicciaro","sequence":"additional","affiliation":[{"name":"Breast Unit, Department of Surgical Science, University of Rome \u201cTor Vergata\u201d, Viale Oxford 81, 00133 Rome, Italy"},{"name":"Ph.D. Program in Applied Medical-Surgical Sciences, Department of Surgical Science, University of Rome \u201cTor Vergata\u201d, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Materazzo","sequence":"additional","affiliation":[{"name":"Breast Unit, Department of Surgical Science, University of Rome \u201cTor Vergata\u201d, Viale Oxford 81, 00133 Rome, Italy"},{"name":"Ph.D. Program in Applied Medical-Surgical Sciences, Department of Surgical Science, University of Rome \u201cTor Vergata\u201d, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5525-4353","authenticated-orcid":false,"given":"Giuseppe","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecological Unit, Department Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oreste Claudio","family":"Buonomo","sequence":"additional","affiliation":[{"name":"Breast Unit, Department of Surgical Science, University of Rome \u201cTor Vergata\u201d, Viale Oxford 81, 00133 Rome, Italy"},{"name":"General Surgery Program, UNIBAS, University of Basilicata, Via dell\u2019Ateneo Lucano, 10, 85100 Potenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3821-201X","authenticated-orcid":false,"given":"Caterina","family":"Exacoustos","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecological Unit, Department of Surgical Science, University of Rome \u201cTor Vergata\u201d, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/humupd\/dmi049","article-title":"Advances in the management of endometriosis: An update for clinicians","volume":"12","author":"Crosignani","year":"2006","journal-title":"Hum. 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