{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:16Z","timestamp":1790294416020,"version":"4.1.0"},"reference-count":61,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Transarterial chemoembolization (TACE) has revolutionized the treatment landscape for malignant liver disease, offering localized therapy with reduced systemic toxicity. This manuscript delves into the use of degradable microspheres (DMS) in TACE, exploring its potential advantages and clinical applications. DMS-TACE emerges as a promising strategy, offering temporary vessel occlusion and optimized drug delivery. The manuscript reviews the existing literature on DMS-TACE, emphasizing its tolerability, toxicity, and efficacy. Notably, DMS-TACE demonstrates versatility in patient selection, being suitable for both intermediate and advanced stages. The unique properties of DMS provide advantages over traditional embolic agents. The manuscript discusses the DMS-TACE procedure, adverse events, and tumor response rates in HCC, ICC, and metastases.<\/jats:p>","DOI":"10.3390\/medicina60040678","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T12:38:41Z","timestamp":1713789521000},"page":"678","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Biodegradable Microspheres for Transarterial Chemoembolization in Malignant Liver Disease"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7713-3272","authenticated-orcid":false,"given":"Ornella","family":"Moschovaki-Zeiger","sequence":"first","affiliation":[{"name":"2nd Department of Radiology, School of Medicine, \u201cAttikon\u201d University General Hospital, National and Kapodistrian University of Athens, GR-124 62 Chaidari, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0783-5700","authenticated-orcid":false,"given":"Nikolaos-Achilleas","family":"Arkoudis","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, School of Medicine, \u201cAttikon\u201d University General Hospital, National and Kapodistrian University of Athens, GR-124 62 Chaidari, Greece"},{"name":"Research Unit of Radiology and Medical Imaging, 2nd Department of Radiology, Medical School, National and Kapodistrian University of Athens, GR-115 28 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Giannakis","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, School of Medicine, \u201cAttikon\u201d University General Hospital, National and Kapodistrian University of Athens, GR-124 62 Chaidari, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Grigoriadis","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, School of Medicine, \u201cAttikon\u201d University General Hospital, National and Kapodistrian University of Athens, GR-124 62 Chaidari, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotis","family":"Anagnostopoulos","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, School of Medicine, \u201cAttikon\u201d University General Hospital, National and Kapodistrian University of Athens, GR-124 62 Chaidari, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1860-0568","authenticated-orcid":false,"given":"Stavros","family":"Spiliopoulos","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, School of Medicine, \u201cAttikon\u201d University General Hospital, National and Kapodistrian University of Athens, GR-124 62 Chaidari, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"ref_1","first-page":"S6-100","article-title":"Spherex (degradable starch microspheres) chemo-occlusion\u2014Enhancement of tumor drug concentration and therapeutic efficacy: An overview","volume":"24","author":"Morales","year":"1997","journal-title":"Semin. 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