{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:53:11Z","timestamp":1761745991034,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: Gastroesophageal reflux disease (GERD) is a common disease affecting approximately 20% of the adult population. This study aimed to compare the results of laparoscopic Nissen fundoplication (LNF) in the treatment of GERD in patients of different age groups. Materials and Methods: A retrospective analysis was performed on patients who underwent LNF in one surgical department between 2014 and 2018. Patients were divided into three groups based on age: under 40 years of age, 40\u201365 years of age, and over 65 years of age. Results: A total of 111 patients (44.1% women) were analyzed in this study. The mean age was 50.2 \u00b115 years, and the mean follow-up was 50 months \u00b1 16.6 months. Recurrence of symptoms occurred in 23%, 20%, and 23% in each age group, respectively (p = 0.13), and 85%, 89%, and 80% of patients from the respective groups reported that they would recommend the surgery to their relatives (p = 0.66). Furthermore, 83%, 92%, and 73% of patients from the respective age groups reported that they would undergo the surgery again with the knowledge they now had (p = 0.16). Conclusions: Given these results and observations, LNF has been shown to be a good method of treatment for GERD in every age group. In our study, there were no differences found in terms of satisfaction with surgery and associated recommendations between the studied age groups.<\/jats:p>","DOI":"10.3390\/medicina60050688","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T03:56:31Z","timestamp":1713930991000},"page":"688","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Age on Long-Term Outcomes of Laparoscopic Nissen Fundoplication\u2014A Single Center Study"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2204-5088","authenticated-orcid":false,"given":"Natalia","family":"Dowgia\u0142\u0142o-Gornowicz","sequence":"first","affiliation":[{"name":"Department of General, Minimally Invasive and Elderly Surgery, Collegium Medicum, University of Warmia and Mazury, Niepodleg\u0142osci 44 St., 10-045 Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3292-3016","authenticated-orcid":false,"given":"Justyna","family":"Kacperczyk","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Children\u2019s Memorial Health Institute, Av. Dzieci Polskich 20, 04-730 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Masiewicz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Military Institute of Medicine, Szaser\u00f3w 128 St., 04-141 Warszawa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8931-9576","authenticated-orcid":false,"given":"Karolina","family":"Osowiecka","sequence":"additional","affiliation":[{"name":"Department of Psychology and Sociology of Health and Public Health, School of Public Health, University of Warmia and Mazury in Olsztyn, Warszawska 30 St., 11-041 Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Lech","sequence":"additional","affiliation":[{"name":"Department of General, Minimally Invasive and Elderly Surgery, Collegium Medicum, University of Warmia and Mazury, Niepodleg\u0142osci 44 St., 10-045 Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"14272","DOI":"10.3748\/wjg.v20.i39.14272","article-title":"Laparoscopic fundoplication for gastroesophageal reflux disease","volume":"20","author":"Frazzoni","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.5114\/wiitm.2018.75909","article-title":"Study of the prevalence of gastroesophageal reflux symptoms and the role of each in relation to the GERD Impact Scale, based on a population of patients admitted for laparoscopic surgery compared to a control group","volume":"13","author":"Frask","year":"2018","journal-title":"Videosurgery Other Miniinvasive Tech."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4240\/wjgs.v8.i1.77","article-title":"Gastroesophageal reflux disease: A review of surgical decision making","volume":"8","author":"Moore","year":"2016","journal-title":"World J. Gastrointest. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4292\/wjgpt.v5.i3.105","article-title":"Diagnosis and treatment of gastroesophageal reflux disease","volume":"5","author":"Badillo","year":"2014","journal-title":"World J. Gastrointest. Pharmacol. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Dowgia\u0142\u0142o-Gornowicz, N., Masiewicz, A., Kacperczyk, J., Lech, P., Saluk, S., Osowiecka, K., and Michalik, M. (2021). Long-Term Outcomes of Chronic Cough Reduction after Laparoscopic Nissen Fundoplication\u2014A Single-Center Study. Medicina, 58.","DOI":"10.3390\/medicina58010047"},{"key":"ref_6","first-page":"S1542","article-title":"Prevalence of Barrett\u2019s Esophagus and Esophageal Adenocarcinoma with and without Gastroesophageal Reflux: A Systematic Review and Meta-analysis","volume":"23","author":"Saha","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1365-2036.2007.03574.x","article-title":"Night-time and daytime atypical manifestations of gastro-oesophageal reflux disease: Frequency, severity and impact on health-related quality of life","volume":"27","author":"Dean","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/j.1365-2036.2012.05086.x","article-title":"Systematic review: The burden of disruptive gastro-oesophageal reflux disease on health-related quality of life","volume":"35","author":"Tack","year":"2012","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"388","DOI":"10.4253\/wjge.v2.i12.388","article-title":"Gastroesophageal reflux disease: Important considerations for the older patients","volume":"2","author":"Chait","year":"2010","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.14309\/ajg.0000000000001538","article-title":"ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease","volume":"117","author":"Katz","year":"2022","journal-title":"Am. J. Gastroenterol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Lee, J., Lee, I., Oh, Y., Kim, J.W., Kwon, Y., Alromi, A., Eledreesi, M., Khalid, A., Aljarbou, W., and Park, S. (2024). Current Status of Anti-Reflux Surgery as a Treatment for GERD. Medicina, 60.","DOI":"10.3390\/medicina60030518"},{"key":"ref_12","unstructured":"WHO Fact Sheet (2023). Ageing and Health, WHO."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.therap.2020.06.019","article-title":"Long-term use of proton pump inhibitors as a risk factor for various adverse manifestations","volume":"76","author":"Koyyada","year":"2021","journal-title":"Therapies"},{"key":"ref_14","first-page":"368","article-title":"Gi Problems in Geriatric Patients: Gastroesophageal Reflux Disease in the Older Patient: Presenta-tion, Treatment, and Complications","volume":"95","author":"Richter","year":"2000","journal-title":"Am. J. Gastroenterol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.amjmed.2009.07.036","article-title":"Review: Treatment of Gastroesophageal Reflux Disease in the Elderly","volume":"123","author":"Poh","year":"2010","journal-title":"Am. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00464-020-07489-5","article-title":"Age-related outcomes in laparoscopic hiatal hernia repair: Is there a \u201ctoo old\u201d for antireflux surgery?","volume":"35","author":"Addo","year":"2021","journal-title":"Surg. Endosc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1136\/gutjnl-2017-314722","article-title":"Modern diagnosis of GERD: The Lyon Consensus","volume":"67","author":"Gyawali","year":"2018","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1007\/s00464-021-08625-5","article-title":"SAGES guidelines for the surgical treatment of gastroesophageal reflux (GERD)","volume":"35","author":"Slater","year":"2021","journal-title":"Surg. Endosc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"740","DOI":"10.3748\/wjg.v13.i5.740","article-title":"Influence of age on outcome of total laparoscopic fundoplication for gastroesophageal reflux disease","volume":"13","author":"Pizza","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1177\/000313480607200904","article-title":"Results after laparoscopic fundoplication: Does age matter?","volume":"72","author":"Cowgill","year":"2006","journal-title":"Am. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1007\/s00268-009-0216-y","article-title":"Impact of Gender and Age on the Long-Term Outcome of Laparoscopic Fundoplication","volume":"33","author":"Beck","year":"2009","journal-title":"World J. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1001\/jama.2017.10981","article-title":"Association Between Laparoscopic Antireflux Surgery and Recurrence of Gastroesophageal Reflux","volume":"318","author":"Wahlin","year":"2017","journal-title":"JAMA"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Lin, H.-S., Watts, J.N., Peel, N.M., and Hubbard, R.E. (2016). Frailty and post-operative outcomes in older surgical patients: A systematic review. BMC Geriatr., 16.","DOI":"10.1186\/s12877-016-0329-8"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1123\/jpah.2021-0013","article-title":"Associations Between Muscular Strength and Gastroesophageal Reflux Disease in Older Adults","volume":"18","author":"Brellenthin","year":"2021","journal-title":"J. Phys. Act. Health"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s00464-014-3660-1","article-title":"Reoperation rates after laparoscopic fundoplication","volume":"29","author":"Zhou","year":"2014","journal-title":"Surg. Endosc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.surg.2006.07.001","article-title":"Outcomes of laparoscopic paraesophageal hernia repair in elderly and high-risk patients","volume":"140","author":"Gangopadhyay","year":"2006","journal-title":"Surgery"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.surg.2014.04.005","article-title":"Outcomes of operations for benign foregut disease in elderly patients: A national surgical quality improvement program database analysis","volume":"156","author":"Molena","year":"2014","journal-title":"Surgery"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1007\/s00268-016-3428-y","article-title":"Laparoscopic Hiatal Hernia Repair in the Elderly Patient","volume":"40","author":"Oor","year":"2016","journal-title":"World J. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9345","DOI":"10.1007\/s00464-022-09209-7","article-title":"Review of SAGES GERD guidelines and recommendations","volume":"36","author":"Mohr","year":"2022","journal-title":"Surg. Endosc."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/5\/688\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:32:57Z","timestamp":1760106777000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/5\/688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,24]]},"references-count":30,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["medicina60050688"],"URL":"https:\/\/doi.org\/10.3390\/medicina60050688","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2024,4,24]]}}}