{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:31:55Z","timestamp":1780065115093,"version":"3.54.0"},"reference-count":68,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: The pancreas, ensconced within the abdominal cavity, requires a plethora of sophisticated imaging modalities for its comprehensive evaluation, with ultrasonography serving as a primary investigative technique. A myriad of pancreatic pathologies, encompassing pancreatic neoplasia and a spectrum of inflammatory diseases, are detectable through these imaging strategies. Nevertheless, the intricate anatomical confluence and the pancreas\u2019s deep-seated topography render the visualization and accurate diagnosis of its pathologies a formidable endeavor. The objective of our paper is to review the best diagnostic imagistic tools for the pancreas. Materials and Methods: we have gathered several articles using Prisma guidelines to determine the best imagistic methods. The imperative of pancreatic scanning transcends its diagnostic utility, proving to be a pivotal element in a multitude of clinical specialties, notably surgical oncology. Within this domain, multidetector computed tomography (MDCT) of the pancreas holds the distinction of being the paramount imaging modality, endorsed for its unrivaled capacity to delineate the staging and progression of pancreatic carcinoma. In synergy with MDCT, there has been a notable advent of avant-garde imaging techniques in recent years. These advanced methodologies, including ultrasonography, endoscopic ultrasonography, contrast-enhanced ultrasonography, and magnetic resonance imaging (MRI) conjoined with magnetic resonance cholangiopancreatography (MRCP), have broadened the horizon of tumor characterization, offering unparalleled depth and precision in oncological assessment. Other emerging diagnostic techniques, such as elastography, also hold a lot of potential and promise for the future of pancreatic imaging. Fine needle aspiration (FNA) is a quick, minimally invasive procedure to evaluate lumps using a thin needle to extract tissue for analysis. It is less invasive than surgical biopsies and usually performed as an outpatient with quick recovery. Its accuracy depends on sample quality, and the risks include minimal bleeding or discomfort. Results, guiding further treatment, are typically available within a week. Elastography is a non-invasive medical imaging technique that maps the elastic properties and stiffness of soft tissue. This method, often used in conjunction with ultrasound or MRI, helps differentiate between hard and soft areas in tissue, providing valuable diagnostic information. It is particularly useful for assessing liver fibrosis, thyroid nodules, breast lumps, and musculoskeletal conditions. The technique is painless and involves applying gentle pressure to the area being examined. The resulting images show tissue stiffness, indicating potential abnormalities. Elastography is advantageous for its ability to detect diseases in early stages and monitor treatment effectiveness. The procedure is quick, safe, and requires no special preparation, with results typically available immediately. Results: The assembled and gathered data shows the efficacy of various techniques in discerning the nature and extent of neoplastic lesions within the pancreas. Conclusions: The most common imaging modalities currently used in diagnosing pancreatic neoplasms are multidetector computed tomography (MDCT), endoscopic ultrasound (EUS), and magnetic resonance imaging (MRI), alongside new technologies, such as elastography.<\/jats:p>","DOI":"10.3390\/medicina60050695","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T10:18:36Z","timestamp":1713953916000},"page":"695","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Revolutionizing the Pancreatic Tumor Diagnosis: Emerging Trends in Imaging Technologies: A Systematic Review"],"prefix":"10.3390","volume":"60","author":[{"given":"Sabina Florina","family":"\u0218olea","sequence":"first","affiliation":[{"name":"Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania"},{"name":"Bihor Clinical County Emergency Hospital, 410169 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3603-8070","authenticated-orcid":false,"given":"Mihaela Cristina","family":"Brisc","sequence":"additional","affiliation":[{"name":"Bihor Clinical County Emergency Hospital, 410169 Oradea, Romania"},{"name":"Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Or\u0103\u0219eanu","sequence":"additional","affiliation":[{"name":"Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania"},{"name":"Bihor Clinical County Emergency Hospital, 410169 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian Ciprian","family":"Venter","sequence":"additional","affiliation":[{"name":"Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania"},{"name":"Bihor Clinical County Emergency Hospital, 410169 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciprian Mihai","family":"Brisc","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u0103zvan Mihai","family":"\u0218olea","sequence":"additional","affiliation":[{"name":"Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4343-4397","authenticated-orcid":false,"given":"Lavinia","family":"Davidescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Venter","sequence":"additional","affiliation":[{"name":"Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4416-2848","authenticated-orcid":false,"given":"Ciprian","family":"Brisc","sequence":"additional","affiliation":[{"name":"Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania"},{"name":"Bihor Clinical County Emergency Hospital, 410169 Oradea, Romania"},{"name":"Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania"},{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7247","DOI":"10.3748\/wjg.v19.i42.7247","article-title":"Ultrasonography in diagnosing chronic pancreatitis: New aspects","volume":"19","author":"Dimcevski","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.pan.2023.12.009","article-title":"International evidence-based Kyoto guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas","volume":"24","author":"Ohtsuka","year":"2024","journal-title":"Pancreatology"},{"key":"ref_3","first-page":"132","article-title":"Which is the Best Imaging Method in Pancreatic Adenocarcinoma Diagnosis and Staging\u2014CT, MRI or EUS?","volume":"43","author":"Costache","year":"2017","journal-title":"Curr. Health Sci. J."},{"key":"ref_4","first-page":"36","article-title":"EFSUMB Technical Review\u2013Update 2023: Dynamic ContrastEnhanced Ultrasound (DCE-CEUS) for the Quantification of Tumor Perfusion Technisches Review der EFSUMB\u2013Update 2023: Dynamischer kontrastverst\u00e4rkter Ultraschall (DCE-US) zur Quantifizierung der Tumorperfusion","volume":"45","author":"Dietrich","year":"2024","journal-title":"Ultraschall Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.3748\/wjg.v25.i9.1080","article-title":"Computed tomography scan imaging in diagnosing acute uncomplicated pancreatitis: Usefulness vs. cost","volume":"25","author":"Kothari","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/00006676-199303000-00002","article-title":"Clinical presentation and ultrasonography in the diagnosis of pancreatic cancer","volume":"8","author":"Maringhini","year":"1993","journal-title":"Pancreas"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1080\/003655202761020605","article-title":"Differentiation of pancreatic tumours by conventional ultrasound, unenhanced and echo-enhanced power Doppler sonography","volume":"37","author":"Rickes","year":"2002","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1148\/rg.2019190011","article-title":"Chronic pancreatitis or pancreatic tumor? A problem-solving approach","volume":"39","author":"Wolske","year":"2019","journal-title":"RadioGraphics"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1007\/s00330-009-1332-7","article-title":"Groove pancreatitis: A diagnostic challenge","volume":"19","author":"Triantopoulou","year":"2009","journal-title":"Eur. Radiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000289099","article-title":"Groove pancreatitis","volume":"27","author":"Tezuka","year":"2010","journal-title":"Dig. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/107327480401100203","article-title":"Applications of endoscopic ultrasonography in pancreatic cancer","volume":"11","author":"Varadarajulu","year":"2004","journal-title":"Cancer Control"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.3748\/wjg.v16.i22.2735","article-title":"Magnetic resonance imaging for local complications of acute pancreatitis: A pictorial review","volume":"16","author":"Xiao","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0002-9610(98)00097-X","article-title":"The incidence of main pancreatic duct disruption in severe biliary pancreatitis","volume":"176","author":"Uomo","year":"1998","journal-title":"Am. J. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"984","DOI":"10.2214\/AJR.08.2034","article-title":"Complementary roles of CT and endoscopic ultrasound in evaluating a pancreatic Mass","volume":"194","author":"Goldberg","year":"2010","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_15","first-page":"220","article-title":"Endoscopic ultrasonography for pancreatic cancer: Current and future perspectives","volume":"4","author":"Angelis","year":"2013","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mri.2017.04.015","article-title":"Magnetic resonance elastography of the pancreas: Measurement reproducibility and relationship with age","volume":"42","author":"Kolipaka","year":"2017","journal-title":"Magn. Reson. Imaging"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"688","DOI":"10.12659\/PJR.903631","article-title":"Assessment of the Pancreas with Strain Elastography in Healthy Children: Correlates and Clinical Implications","volume":"82","author":"Citil","year":"2017","journal-title":"Pol. J. Radiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00247-020-04863-2","article-title":"Pancreas ultrasound two-dimensional shear wave elastography in healthy children","volume":"51","author":"Qiu","year":"2021","journal-title":"Pediatr. Radiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3233\/CH-190665","article-title":"Quantitative shear wave elastography for noninvasive assessment of solid pancreatic masses","volume":"74","author":"Xie","year":"2020","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3949\/ccjm.87a.19003","article-title":"Endoscopic ultrasonography: An inside view","volume":"87","author":"Wander","year":"2020","journal-title":"Clevel. Clin. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"17060","DOI":"10.1038\/nrdp.2017.60","article-title":"Chronic pancreatitis","volume":"3","author":"Kleeff","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_22","first-page":"628","article-title":"The utility of ealry cross-sectional imaging to evaluate suspected acute mild pancreatitis","volume":"31","author":"Reynolds","year":"2018","journal-title":"Ann. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"322","DOI":"10.14309\/ajg.0000000000000535","article-title":"ACG Clinical Guideline: Chronic Pancreatitis","volume":"115","author":"Gardner","year":"2020","journal-title":"Am. J. Gastroenterol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.pan.2018.08.012","article-title":"Guidelines for the Diagnostic Cross Sectional Imaging and Severity Scoring of Chronic Pancreatitis","volume":"18","author":"Frokjaer","year":"2018","journal-title":"Pancreatology."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/0016-5085(94)90553-3","article-title":"The different courses of early- and late-onset idiopathic and alcoholic chronic pancreatitis","volume":"107","author":"Layer","year":"1994","journal-title":"Gastroenterology."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00535-006-1945-4","article-title":"The M-ANNHEIM classification of chronic pancreatitis: Introduction of a unifying classification system based on a review of previous classifications of the disease","volume":"42","author":"Schneider","year":"2007","journal-title":"J. Gastroenterol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Buchler, M.W., Martignoni, M.E., Friess, H., and Malfertheiner, P. (2009). A proposal for a new clinical classification of chronic pancreatitis. BMC Gastroenterol., 9.","DOI":"10.1186\/1471-230X-9-93"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Jimenez, R.E., and Fernandez-Del Castillo, C. (2010). Tumors of the Pancreas. Sleisenger and Fordtran\u2019s Gastrointestinal and Liver Disease, Elsevier.","DOI":"10.1016\/B978-1-4160-6189-2.00060-3"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/ajg.2011.68","article-title":"Pancreatic cancer surveillance: Learning as we go","volume":"106","author":"Brentnall","year":"2011","journal-title":"Am. J. Gastroenterol."},{"key":"ref_30","unstructured":"Meseeha, M., and Attia, M. (2023). Endoscopic Retrograde Cholangiopancreatography, StatPearls."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"360","DOI":"10.4251\/wjgo.v6.i9.360","article-title":"Role of endoscopic ultrasound in the diagnosis of pancreatic cancer","volume":"6","author":"Vila","year":"2014","journal-title":"World J. Gastrointest. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Faias, S., Cravo, M., da Silva, J.P., and Chaves, P. (2020). Endoscopic ultrasound with fine needle aspiration is useful in pancreatic cysts smaller than 3 cm. BMC Gastroenterol., 20.","DOI":"10.1186\/s12876-020-01565-9"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.gie.2011.08.049","article-title":"EUS-guided FNA for diagnosis of solid pancreatic neoplasms: A meta-analysis","volume":"75","author":"Hewitt","year":"2012","journal-title":"Gastrointest. Endosc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"272","DOI":"10.4253\/wjge.v6.i7.272","article-title":"Endoscopic ultrasonography for surveillance of individuals at high risk for pancreatic cancer","volume":"6","author":"Lami","year":"2014","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4103\/2303-9027.117691","article-title":"Endoscopic ultrasound-guided fine needle aspiration: From the past to the future","volume":"2","author":"Costache","year":"2013","journal-title":"Endosc. Ultrasound."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s13244-022-01297-2","article-title":"Dual-energy CT with virtual monoenergetic images and iodine maps improves tumor conspicuity in patients with pancreatic ductal adenocarcinoma","volume":"13","author":"Liang","year":"2022","journal-title":"Insights Imaging"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13244-020-00861-y","article-title":"Imagins Diagnosis and Staging of pancreatal Ductal Adenocarcinoma: A Comprehensive review","volume":"11","author":"Elbanna","year":"2020","journal-title":"Insight Imaging"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41575-019-0195-x","article-title":"Diagnosis and management of pancreatic cystic neoplasms: Current evidence and guidelines","volume":"16","author":"Wolfgang","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.3748\/wjg.v23.i17.3184","article-title":"Comparison of endoscopic ultrasound, computed tomography and magnetic resonance imaging in assessment of detailed structures of pancreatic cystic neoplasms","volume":"23","author":"Du","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"294","DOI":"10.4103\/ijri.IJRI_437_19","article-title":"Comparative analysis and assessment of diagnostic accuracy of 256 slice CT and endoscopic ultrasound in evaluation of pancreatic masses","volume":"30","author":"Gupta","year":"2020","journal-title":"Indian J. Radiol. Imaging"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"533","DOI":"10.5946\/ce.2018.156","article-title":"Elastography of the Pancreas, Current View","volume":"52","author":"Dietrich","year":"2019","journal-title":"Clin. Endosc."},{"key":"ref_42","first-page":"624","article-title":"Diagnostic performance of contrast-enhanced ultrasound (CEUS) and contrast-enhanced endoscopic ultrasound (ECEUS) for the differentiation of pancreatic lesions: A systematic review and meta-analysis","volume":"56","author":"Biagioli","year":"2020","journal-title":"Medicina"},{"key":"ref_43","first-page":"203","article-title":"Cardiovascular Imaging with CEUS","volume":"27","author":"Green","year":"2020","journal-title":"Cardiol. Today"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Tong, T., Gu, J., Xu, D., Song, L., Zhao, Q., Cheng, F., Yuan, Z., Tian, S., Yang, X., and Tian, J. (2022). Deep learning radiomics based on contrast-enhanced ultrasound images for assisted diagnosis of pancreatic ductal adenocarcinoma and chronic pancreatitis. BMC Med., 20.","DOI":"10.1186\/s12916-022-02258-8"},{"key":"ref_45","unstructured":"Han, H. (2024, March 26). Ultrasound Activated Microbubbles Enhance the Activity of Standard of Care Therapeutics in Pancreatic Cancer. Available online: https:\/\/www.tgen.org\/news\/2022\/november\/22\/ultrasound-activated-microbubbles-enhance-the-activity-of-standard-of-care-therapeutics-in-pancreatic-cancer\/."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4329\/wjr.v1.i1.15","article-title":"Contrast-enhanced ultrasound: The evolving applications","volume":"1","author":"Xu","year":"2009","journal-title":"World J. Radiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1007\/s00261-017-1315-0","article-title":"Applications of contrast-enhanced ultrasound in the pediatric abdomen","volume":"43","author":"Ntoulia","year":"2018","journal-title":"Abdom. Radiol."},{"key":"ref_48","first-page":"e18243","article-title":"Contrast-Enhanced Ultrasonography: Review and Applications","volume":"13","author":"Ajmal","year":"2021","journal-title":"Cureus"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Carmicheal, J., Patel, A., Dalal, V., Atri, P., Dhaliwal, A.S., Wittel, U.A., Malafa, M.P., Talmon, G., Swanson, B.J., and Singh, S. (2020). Elevating pancreatic cystic lesion stratification: Current and future pancreatic cancer biomarker(s). Biochim. Biophys. Acta Rev. Cancer, 1873.","DOI":"10.1016\/j.bbcan.2019.188318"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e2337799","DOI":"10.1001\/jamanetworkopen.2023.37799","article-title":"Long-Term Outcomes and Risk of Pancreatic Cancer in Intraductal Papillary Mucinous Neoplasms","volume":"6","author":"Chatterjee","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"ref_51","unstructured":"Mangiavillano, B., Frazzoni, L., Togliani, T., Fabbri, C., Tarantino, I., De Luca, L., Staiano, T., Binda, C., Signoretti, M., and Eusebi, L.H. (2024, March 26). Evaluation of Solid Lesion Specimens via Macroscopic On-Site Evaluation during EUS-FNB Across Multiple Centers: A Comparative Analysis of Different Needle Sizes. Available online: https:\/\/www.thieme-connect.de\/products\/ejournals\/abstract\/10.1055\/a-1395-7129."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.annonc.2023.08.009","article-title":"Pancreatic cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"34","author":"Conroy","year":"2023","journal-title":"Ann. Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s10147-023-02317-x","article-title":"Clinical Practice Guidelines for Pancreatic Cancer 2022 from the Japan Pancreas Society: A synopsis","volume":"28","author":"Okusaka","year":"2023","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/13651820500540949","article-title":"Diagnosis of pancreatic cancer","volume":"8","author":"Miura","year":"2006","journal-title":"HPB"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.crad.2010.06.019","article-title":"Relative accuracy of CT and MRI in the differentiation of benign from malignant pancreatic cystic lesions","volume":"66","author":"Lee","year":"2011","journal-title":"Clin. Radiol."},{"key":"ref_56","first-page":"537","article-title":"Advanced EUS Imaging for Pancreatic Diseases: CE-EUS (Low-MI, High-MI) and Real-Time Elastography, 3D","volume":"1","author":"Hocke","year":"2013","journal-title":"Video J. Encyc. GI Endosc."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1055\/s-0031-1273247","article-title":"Real-Time Elastography: Strain Ratio Measurements Are Influenced by the Position of the Reference Area","volume":"33","author":"Havre","year":"2012","journal-title":"Ultraschall Med."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Yamamiya, A., Irisawa, A., Hoshi, K., Yamabe, A., Izawa, N., Nagashima, K., Minaguchi, T., Yamaura, M., Yoshida, Y., and Kashima, K. (2021). Recent Advances in Endosonography\u2014Elastography. J. Clin. Med., 10.","DOI":"10.3390\/jcm10163739"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"20","DOI":"10.14366\/usg.22103","article-title":"The efficiency of contrast-enhanced endoscopic ultrasound (EUS) combined with EUS elastography for pancreatic cancer diagnosis: A systematic review and meta-analysis","volume":"42","author":"Shin","year":"2023","journal-title":"Ultrasonography"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.7150\/thno.18650","article-title":"Ultrasound Elastography: Review of Techniques and Clinical Applications","volume":"7","author":"Sigrist","year":"2017","journal-title":"Theranostics"},{"key":"ref_61","first-page":"672","article-title":"Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and real-time tissue elastography","volume":"56","author":"Koch","year":"2012","journal-title":"J. Hepatol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1053\/j.gastro.2007.11.053","article-title":"Noninvasive Assessment of Liver Fibrosis and Portal Hypertension with Transient Elastography","volume":"134","author":"Rockey","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_63","first-page":"48","article-title":"Endoscopic ultrasound elastography","volume":"8","author":"Arcidiacono","year":"2012","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"909","DOI":"10.3748\/wjg.v28.i9.909","article-title":"Applications of endoscopic ultrasound elastography in pancreatic diseases: From literature to real life","volume":"28","author":"Conti","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"P\u00fcttmann, S., Koch, J., Steinacker, J.P., Schmidt, S.A., Seufferlein, T., Kratzer, W., Schmidberger, J., and Manfras, B. (2018). Ultrasound point sheer wave elastography of the pancreas: Comparison of patients with type 1 diabetes and healthy volunteers\u2014Results from a pilot study. BMC Med. Imaging, 18.","DOI":"10.1186\/s12880-018-0295-z"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12014-018-9221-1","article-title":"High accuracy differentiating autoimmune pancreatitis from pancreatic ductal adenocarcinoma by immunoglobulin G glycosylation","volume":"16","author":"Shih","year":"2019","journal-title":"Clin. Proteom."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Yan, T., Ke, Y., Chen, Y., Xu, C., Yu, C., and Li, Y. (2017). Serological characteristics of autoimmune pancreatitis and its differential diagnosis from pancreatic cancer by using a combination of carbohydrate antigen 19-9, globulin, eosinophils and hemoglobin. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0174735"},{"key":"ref_68","first-page":"11","article-title":"Differentiation of autoimmune pancreatitis from pancreas cancer: Utility of anti-amylase and anti-carbonic anhydrase II autoantibodies","volume":"3","year":"2011","journal-title":"Auto Immun. Highlights"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/5\/695\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:33:19Z","timestamp":1760106799000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/5\/695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,24]]},"references-count":68,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["medicina60050695"],"URL":"https:\/\/doi.org\/10.3390\/medicina60050695","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,24]]}}}