{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:51:57Z","timestamp":1791229917359,"version":"4.1.0"},"reference-count":68,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and Breast Implant-Associated Squamous Cell Carcinoma (BIA-SCC) are emerging neoplastic complications related to breast implants. While BIA-ALCL is often linked to macrotextured implants, current evidence does not suggest an implant-type association for BIA-SCC. Chronic inflammation and genetics have been hypothesized as key pathogenetic players, although for both conditions, the exact mechanisms and specific risks related to breast implants are yet to be established. While the genetic alterations in BIA-SCC are still unknown, JAK-STAT pathway activation has been outlined as a dominant signature of BIA-ALCL. Recent genetic investigation has uncovered various molecular players, including MEK-ERK, PI3K\/AKT, CDK4-6, and PDL1. The clinical presentation of BIA-ALCL and BIA-SCC overlaps, including most commonly late seroma and breast swelling, warranting ultrasound and cytological examinations, which are the first recommended steps as part of the diagnostic work-up. While the role of mammography is still limited, MRI and CT-PET are recommended according to the clinical presentation and for disease staging. To date, the mainstay of treatment for BIA-ALCL and BIA-SCC is implant removal with en-bloc capsulectomy. Chemotherapy and radiation therapy have also been used for advanced-stage BIA-ALCL and BIA-SCC. In-depth characterization of the tumor genetics is key for the development of novel therapeutic strategies, especially for advanced stage BIA-ALCL and BIA-SCC, which show a more aggressive course and poor prognosis.<\/jats:p>","DOI":"10.3390\/medicina60050793","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T05:25:47Z","timestamp":1715318747000},"page":"793","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["BIA-ALCL and BIA-SCC: Updates on Clinical Features and Genetic Mutations for Latest Recommendations"],"prefix":"10.3390","volume":"60","author":[{"given":"Gennaro","family":"D\u2019Orsi","sequence":"first","affiliation":[{"name":"PhD School of Applied Medical-Surgical Sciences, Tor Vergata University of Rome, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Giacalone","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery at Department of Surgical Science, Tor Vergata University of Rome, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Calicchia","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery at Department of Surgical Science, Tor Vergata University of Rome, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elettra","family":"Gagliano","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery at Department of Surgical Science, Tor Vergata University of Rome, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Vannucchi","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery at Department of Surgical Science, Tor Vergata University of Rome, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Vanni","sequence":"additional","affiliation":[{"name":"Division of Breast Unit, Department of Surgical Sciences, School of Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oreste Claudio","family":"Buonomo","sequence":"additional","affiliation":[{"name":"Division of Breast Unit, Department of Surgical Sciences, School of Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Cervelli","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery at Department of Surgical Science, Tor Vergata University of Rome, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8671-0609","authenticated-orcid":false,"given":"Benedetto","family":"Longo","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery at Department of Surgical Science, Tor Vergata University of Rome, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/asj\/sju006","article-title":"Breast implants and the risk of breast cancer: A meta-analysis of cohort studies","volume":"35","author":"Noels","year":"2015","journal-title":"Aesthet. Surg. J."},{"key":"ref_2","unstructured":"U.S. Food and Drug Administration (2024, March 23). Breast Implants: Reports of Squamous Cell Carcinoma and Various Lymphomas in Capsule Around Implants: FDA Safety Communication., Available online: https:\/\/www.fda.gov\/medical-devices\/safety-communications\/breast-implants-reports-squamous-cell-carcinoma-and-various-lymphomas-capsule-around-implants-fda."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/00006534-199708000-00065","article-title":"Anaplastic T-cell lymphoma in proximity to a saline-filled breast implant","volume":"100","author":"Keech","year":"1997","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/1097-0142(19940301)73:5<1449::AID-CNCR2820730520>3.0.CO;2-J","article-title":"Epithelialization of the lining of a breast implant capsule. Possible origins of squamous cell carcinoma associated with a breast implant capsule","volume":"73","author":"Kitchen","year":"1994","journal-title":"Cancer"},{"key":"ref_5","unstructured":"(2024, March 23). Medical Device Reports of Breast Implant-Associated Anaplastic Large Cell Lymphoma, Available online: https:\/\/www.fda.gov\/medical-devices\/breast-implants\/medical-device-reports-breast-implant-associated-anaplastic-large-cell-lymphoma."},{"key":"ref_6","unstructured":"(2024, March 23). UPDATE: Reports of Squamous Cell Carcinoma (SCC) in the Capsule Around Breast Implants\u2014FDA Safety Communication, Available online: https:\/\/www.fda.gov\/medical-devices\/safety-communications\/update-reports-squamous-cell-carcinoma-scc-capsule-around-breast-implants-fda-safety-communication."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1055\/a-2073-9534","article-title":"Breast Implant-Associated Tumors","volume":"83","author":"Kremer","year":"2023","journal-title":"Geburtshilfe Frauenheilkd."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ejca.2021.01.041","article-title":"Chest wall infiltration is a critical prognostic factor in breast implant-associated anaplastic large-cell lymphoma affected patients","volume":"148","author":"Campanale","year":"2021","journal-title":"Eur. J. Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"530e","DOI":"10.1097\/PRS.0000000000007240","article-title":"The Crucial Role of Surgical Treatment in BIA-ALCL Prognosis in Early- and Advanced-Stage Patients","volume":"146","author":"Campanale","year":"2020","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.humpath.2017.07.011","article-title":"Breast implant capsule-associated squamous cell carcinoma: A report of 2 cases","volume":"67","author":"Olsen","year":"2017","journal-title":"Hum. Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/SAP.0000000000002524","article-title":"Squamous Cell Carcinoma Arising in Breast Implant Capsules","volume":"86","author":"Goldberg","year":"2021","journal-title":"Ann. Plast. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/00000637-199211000-00009","article-title":"Squamous cell carcinoma following breast augmentation","volume":"29","author":"Paletta","year":"1992","journal-title":"Ann. Plast. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.1097\/01.PAT.0000461520.64127.87","article-title":"Breast implant-associated squamous cell carcinoma\u2014A rare long term complication","volume":"47","author":"Satgunaseelan","year":"2015","journal-title":"Pathology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e586","DOI":"10.1097\/GOX.0000000000000567","article-title":"Primary Squamous Cell Carcinoma Arising from a Breast Implant Capsule","volume":"3","author":"Zomerlei","year":"2016","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_15","first-page":"NP 97","article-title":"Primary Squamous Cell Carcinoma Arising from a Breast Implant Capsule: A Case Report and Review of the Literature","volume":"38","author":"Buchanan","year":"2018","journal-title":"Aesthet. Surg. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1177\/10668969221086940","article-title":"Breast Implant Capsule-Associated Squamous Cell Carcinoma: Report of 2 Patients","volume":"30","author":"Whaley","year":"2022","journal-title":"Int. J. Surg. Pathol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"926e","DOI":"10.1097\/PRS.0000000000009506","article-title":"Breast Implant Capsule-Associated Squamous Cell Carcinoma during Pregnancy: A Mimicker of Breast Implant-Associated Anaplastic Large-Cell Lymphoma","volume":"150","author":"Soni","year":"2022","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/10408447609164018","article-title":"Foreign body tumorigenesis","volume":"4","author":"Brand","year":"1976","journal-title":"CRC Crit. Rev. Toxicol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1097\/01.prs.0000260582.23971.02","article-title":"Cancer risk among Los Angeles women with cosmetic breast implants","volume":"119","author":"Deapen","year":"2007","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.smim.2007.11.004","article-title":"Foreign body reaction to biomaterials","volume":"20","author":"Anderson","year":"2008","journal-title":"Semin. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"30e","DOI":"10.1097\/PRS.0000000000007423","article-title":"Cellular and Molecular Mechanisms of Breast Implant-Associated Anaplastic Large Cell Lymphoma","volume":"147","author":"DeCoster","year":"2021","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1097\/PRS.0000000000003282","article-title":"U.S. Epidemiology of Breast Implant-Associated Anaplastic Large Cell Lymphoma","volume":"139","author":"Doren","year":"2017","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_23","unstructured":"Swerdlow, S.H., Campo, E., Harris, N.L., Jaffe, E.S., Pileri, S.A., Stein, H., Thiele, J., and Vardiman, J.W. (2017). Breast implant-associated anaplastic large cell lymphoma, WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1007\/s00266-023-03377-0","article-title":"EBV-Positive Diffuse Large B-Cell Lymphoma in Association with Polyurethane Textured Breast Implants: Case Report and Literature Overview","volume":"47","author":"Brondeel","year":"2023","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1182\/blood-2017-12-821868","article-title":"Genetic subtyping of breast implant-associated anaplastic large cell lymphoma","volume":"132","author":"Oishi","year":"2018","journal-title":"Blood"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"104982","DOI":"10.1016\/j.yrtph.2021.104982","article-title":"Final opinion on the safety of breast implants in relation to anaplastic large cell lymphoma: Report of the scientific committee on health, emerging and environmental risks (SCHEER)","volume":"125","author":"Panagiotakos","year":"2021","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Deva, A.K., Turner, S.D., Kadin, M.E., Magnusson, M.R., Prince, H.M., Miranda, R.N., Inghirami, G.G., and Adams, W.P. (2020). Etiology of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): Current Directions in Research. Cancers, 12.","DOI":"10.3390\/cancers12123861"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Mempin, M., Hu, H., Vickery, K., Kadin, M.E., Prince, H.M., Kouttab, N., Morgan, J.W., Adams, W.P., and Deva, A.K. (2021). Gram-Negative Bacterial Lipopolysaccharide Promotes Tumor Cell Proliferation in Breast Implant-Associated Anaplastic Large-Cell Lymphoma. Cancers, 13.","DOI":"10.3390\/cancers13215298"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13000-018-0688-x","article-title":"Breast implant-associated anaplastic large cell lymphoma in a Li-FRAUMENI patient: A case report","volume":"13","author":"Pastorello","year":"2018","journal-title":"Diagn. Pathol."},{"key":"ref_30","first-page":"51","article-title":"The use of ExashapeTM Bioshield Pocket in prepectoral breast reconstruction: A preliminary experience","volume":"1","author":"Mazzocchi","year":"2022","journal-title":"Plast. Reconstr. Regen. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1097\/PRS.0000000000002010","article-title":"Bacterial Biofilm Infection Detected in Breast Implant-Associated Anaplastic Large-Cell Lymphoma","volume":"137","author":"Hu","year":"2016","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"10393","DOI":"10.1038\/s41598-019-46535-8","article-title":"Insights into the Microbiome of Breast Implants and Periprosthetic Tissue in Breast Implant-Associated Anaplastic Large Cell Lymphoma","volume":"9","author":"Walker","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"471e","DOI":"10.1097\/PRS.0000000000000020","article-title":"In vitro and in vivo investigation of the influence of implant surface on the formation of bacterial biofilm in mammary implants","volume":"133","author":"Jacombs","year":"2014","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13000-023-01337-5","article-title":"Breast implant associated EBV-positive Diffuse Large B-cell lymphoma: An underrecognized entity?","volume":"18","author":"Vets","year":"2023","journal-title":"Diagn. Pathol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.ejso.2020.10.029","article-title":"Biological and genetic landscape of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL)","volume":"47","author":"Rangel","year":"2021","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1182\/blood.2019004498","article-title":"Increased prevalence of BRCA1\/2 mutations in women with macrotextured breast implants and anaplastic large cell lymphoma of the breast","volume":"136","author":"Hauptmann","year":"2020","journal-title":"Blood"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/his.12737","article-title":"Breast implant-associated anaplastic large cell lymphoma in a patient with Li-Fraumeni syndrome","volume":"67","author":"Lee","year":"2015","journal-title":"Histopathology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.clbc.2013.08.009","article-title":"Implant-associated primary anaplastic large-cell lymphoma with simultaneous involvement of bilateral breast capsules","volume":"13","author":"Nademanee","year":"2013","journal-title":"Clin. Breast Cancer"},{"key":"ref_39","first-page":"7","article-title":"Breast Implant. Associated-Anaplastic Large Cell Lymphoma development case in a set of dizygotic twins with breast implants. A case report","volume":"2","author":"Latini","year":"2023","journal-title":"Plast. Reconstr. Regen. Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/bjh.14431","article-title":"Targeted next generation sequencing of breast implant-associated anaplastic large cell lymphoma reveals mutations in JAK\/STAT signalling pathway genes, TP53 and DNMT3A","volume":"180","author":"Jain","year":"2018","journal-title":"Br. J. Haematol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e387","DOI":"10.3324\/haematol.2016.146118","article-title":"Whole exome sequencing reveals activating JAK1 and STAT3 mutations in breast implant-associated anaplastic large cell lymphoma anaplastic large cell lymphoma","volume":"101","author":"Blombery","year":"2016","journal-title":"Haematologica"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"36126","DOI":"10.18632\/oncotarget.26308","article-title":"Frequent activating STAT3 mutations and novel recurrent genomic abnormalities detected in breast implant-associated anaplastic large cell lymphoma","volume":"9","author":"Blombery","year":"2018","journal-title":"Oncotarget"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1007\/s00266-017-1064-z","article-title":"Spontaneous Regression and Resolution of Breast Implant-Associated Anaplastic Large Cell Lymphoma: Implications for Research, Diagnosis and Clinical Management","volume":"42","author":"Fleming","year":"2018","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1158\/1078-0432.CCR-12-0101","article-title":"Survival signals and targets for therapy in breast implant-associated ALK\u2014Anaplastic large cell lymphoma","volume":"18","author":"Lechner","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.3324\/haematol.2019.245860","article-title":"Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma","volume":"106","author":"Oishi","year":"2021","journal-title":"Haematologica"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/cncr.25654","article-title":"Breast implant-associated, ALK-negative, T-cell, anaplastic, large-cell lymphoma: Establishment and characterization of a model cell line (TLBR-1) for this newly emerging clinical entity","volume":"117","author":"Lechner","year":"2011","journal-title":"Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41375-018-0239-1","article-title":"Dependency on the TYK2\/STAT1\/MCL1 axis in anaplastic large cell lymphoma [published correction appears in Leukemia. 2020 Nov;34(11):3105]","volume":"33","author":"Prutsch","year":"2019","journal-title":"Leukemia"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.humpath.2019.05.007","article-title":"Recurrent PDL1 expression and PDL1 (CD274) copy number alterations in breast implant-associated anaplastic large cell lymphomas","volume":"90","author":"Tabanelli","year":"2019","journal-title":"Hum. Pathol."},{"key":"ref_49","first-page":"3105","article-title":"PD-1\/PD-L1 Checkpoint in Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Case Report","volume":"3","author":"Bianchi","year":"2018","journal-title":"Biomed. J. Sci. Tech. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"103401","DOI":"10.1016\/j.retram.2023.103401","article-title":"Establishment and characterization of a novel breast implant-associated anaplastic large cell lymphoma cell line and PDX model (BIA-XR1) with a unique KRAS mutation","volume":"71","author":"Xagoraris","year":"2023","journal-title":"Curr. Res. Transl. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"107377","DOI":"10.1016\/j.leukres.2023.107377","article-title":"PI3K\/AKT inhibitor BEZ-235 targets CCND2 and induces G1 arrest in breast implant-associated anaplastic large cell lymphoma","volume":"133","author":"Nagel","year":"2023","journal-title":"Leuk. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.breast.2022.11.009","article-title":"Clinical recommendations for diagnosis and treatment according to current updated knowledge on BIA-ALCL","volume":"66","author":"Longo","year":"2022","journal-title":"Breast"},{"key":"ref_53","first-page":"3483","article-title":"Locally advanced breast implant-associated anaplastic large-cell lymphoma: A combined medical-surgical approach","volume":"25","author":"Caputo","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_54","unstructured":"(2024, March 23). ASPS Statement on Breast Implant Associated-Squamous Cell Carcinoma (BIA-SCC). Available online: https:\/\/www.plasticsurgery.org\/for-medical-professionals\/publications\/psn-extra\/news\/asps-statement-on-breast-implant-associated-squamous-cell-carcinoma."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/asj\/sjw259","article-title":"NCCN Consensus Guidelines for the Diagnosis and Management of Breast Implant-Associated Anaplastic Large Cell Lymphoma","volume":"37","author":"Clemens","year":"2017","journal-title":"Aesthet. Surg. J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/PRS.0b013e318217fdb0","article-title":"Managing late periprosthetic fluid collections (seroma) in patients with breast implants: A consensus panel recommendation and review of the literature","volume":"128","author":"Bengtson","year":"2011","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_57","first-page":"e3405","article-title":"Breast Squamous Cell Carcinoma Following Breast Augmentation","volume":"10","author":"Zhou","year":"2018","journal-title":"Cureus"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"983611","DOI":"10.3389\/fsurg.2022.983611","article-title":"Breast implant-associated squamous cell carcinoma in a male patient: A case report and review of the medical literature","volume":"9","author":"Xia","year":"2023","journal-title":"Front. Surg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e5262","DOI":"10.1097\/GOX.0000000000005262","article-title":"The Ergonomic FALD Flap for One-stage Total Breast Reconstruction","volume":"11","author":"Longo","year":"2023","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.bjps.2023.07.016","article-title":"Narrow inferior-central septum-based pedicle: A safe technique to improve aesthetic outcomes in breast reduction","volume":"85","author":"Longo","year":"2023","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1097\/PRS.0000000000010480","article-title":"Fat-Augmented Latissimus Dorsi Flap for Secondary Breast Reconstruction in Small to Medium-Sized Irradiated Breasts","volume":"152","author":"Longo","year":"2023","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bjps.2024.01.014","article-title":"The FALD-V: A predictive formula for preoperative volume assessment of adipose tissue transplantation in FALD flap","volume":"90","author":"Longo","year":"2024","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_63","first-page":"98","article-title":"Calcaneal hybrid reconstruction with femur head allograft enriched with bone marrow and ALT flap","volume":"2","author":"Longo","year":"2023","journal-title":"Plast. Reconstr. Regen. Surg."},{"key":"ref_64","first-page":"98","article-title":"Microsurgical reconstruction of lower extremity in homozygosity of C677T MTHFR gene mutation: Case report and review of the literature","volume":"1","author":"Longo","year":"2023","journal-title":"Plast. Reconstr. Regen. Surg."},{"key":"ref_65","first-page":"64","article-title":"T-inverted shaped rectus abdominis myocutaneous (Ti-RAM) flap for chest wall reconstruction","volume":"1","author":"Longo","year":"2022","journal-title":"Plast. Reconstr. Regen. Surg."},{"key":"ref_66","first-page":"20","article-title":"Lympho-diep flap transfer perfused by reverse-flow thoracodorsal artery: A case report","volume":"2","author":"Longo","year":"2023","journal-title":"Plast. Reconstr. Regen. Surg."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.clinimag.2021.11.011","article-title":"Implant deformity on screening mammography, an unusual presentation of breast implant associated lymphoma","volume":"82","author":"Thambavitage","year":"2022","journal-title":"Clin. Imaging"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Bayareh-Mancilla, R., Medina-Ramos, L.A., Toriz-V\u00e1zquez, A., Hern\u00e1ndez-Rodr\u00edguez, Y.M., and Cigarroa-Mayorga, O.E. (2023). Automated Computer-Assisted Medical Decision-Making System Based on Morphological Shape and Skin Thickness Analysis for Asymmetry Detection in Mammographic Images. Diagnostics, 13.","DOI":"10.3390\/diagnostics13223440"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/5\/793\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:43:12Z","timestamp":1760107392000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/5\/793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,10]]},"references-count":68,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["medicina60050793"],"URL":"https:\/\/doi.org\/10.3390\/medicina60050793","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,10]]}}}