{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:53:03Z","timestamp":1781877183377,"version":"3.54.5"},"reference-count":51,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Osteonecrosis of the jaw (ONJ) can occur through various mechanisms including radiation, medication, and viral infections such as herpes zoster. Although herpes zoster is a varicella-zoster virus infection that can affect the trigeminal nerve, it rarely causes oral complications. The author reports a rare case of herpes zoster-related ONJ, followed by a review of the relevant literature pertaining to herpes zoster-related oral complications, including ONJ. A 73-year-old woman presented with a scarred skin lesion on her left midface with an exposed alveolar bone of the left maxilla. Based on her medical records, she received a diagnosis and treatment for herpes zoster six months prior and experienced a few teeth loss in the left maxilla following a fall preceding the onset of herpes zoster. Sequestrectomy of the left maxilla was performed and ONJ was diagnosed. The operative site recovered favorably. Although unusual, several cases of localized extensive ONJ in herpes zoster-infected patients have been reported. This case illustrates the possibility of a rare occurrence of unilateral widespread osteonecrosis of the jaw (ONJ) even in the maxilla associated with herpes zoster. The exact mechanism has not been elucidated; nevertheless, surgeons should consider the possibility of oral and dental complications, including ONJ, related to a history of herpes zoster.<\/jats:p>","DOI":"10.3390\/medicina60060883","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T03:48:49Z","timestamp":1716868129000},"page":"883","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maxillary Osteonecrosis Related with Herpes Zoster: A Case Report and Review of the Literature"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0254-279X","authenticated-orcid":false,"given":"Kwan-Soo","family":"Park","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Inje University Sanggye-Paik Hospital, Seoul 01757, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s40257-013-0011-2","article-title":"Management of herpes zoster and post-herpetic neuralgia","volume":"14","author":"Gan","year":"2013","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s11940-013-0246-5","article-title":"Complications of varicella zoster virus reactivation","volume":"15","author":"Nagel","year":"2013","journal-title":"Curr. Treat. Options Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"864","DOI":"10.14219\/jada.archive.2009.0280","article-title":"Bisphosphonate and nonbisphosphonate-associated osteonecrosis of the jaw: A review","volume":"140","author":"Almazrooa","year":"2009","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0030-4220(83)90053-1","article-title":"Alveolar bone necrosis and tooth loss: A rare complication associated with herpes zoster infection of the fifth cranial nerve","volume":"56","author":"Wright","year":"1983","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jbmr.2405","article-title":"Diagnosis and management of osteonecrosis of the jaw: A systematic review and international consensus","volume":"30","author":"Khan","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.joms.2022.02.008","article-title":"American Association of Oral and Maxillofacial Surgeons\u2019 position paper on medication-related osteonecrosis of the jaws\u20142022 update","volume":"80","author":"Ruggiero","year":"2022","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bjoms.2005.05.008","article-title":"Herpes zoster associated with tooth resorption and periapical lesions","volume":"45","author":"Ramchandani","year":"2007","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"214","DOI":"10.4103\/0970-9290.159175","article-title":"Dental complications of herpes zoster: Two case reports and review of literature","volume":"26","author":"Gupta","year":"2015","journal-title":"Indian J. Dent. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/j.tripleo.2010.04.026","article-title":"Unusual oral complications of herpes zoster infection: Report of a case and review of literature","volume":"110","author":"Jain","year":"2010","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontology"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Gershon, A.A., Breuer, J., Cohen, J.I., Cohrs, R.J., Gershon, M.D., Gilden, D., Grose, C., Hambleton, S., Kennedy, P.G., and Oxman, M.N. (2015). Varicella zoster virus infection. Nat. Rev. Dis. Primers, 1.","DOI":"10.1038\/nrdp.2015.16"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1902\/jop.2005.76.1.148","article-title":"Alveolar bone necrosis and tooth exfoliation following herpes zoster infection: A review of the literature and case report","volume":"76","author":"Mendieta","year":"2005","journal-title":"J. Periodontol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10006-016-0561-6","article-title":"A rare case report and appraisal of the literature on spontaneous tooth exfoliation associated with trigeminal herpes zoster","volume":"20","author":"Kaur","year":"2016","journal-title":"Oral Maxillofac. Surg."},{"key":"ref_13","first-page":"1437","article-title":"Herpes Zoster Infection of Maxillary and Mandibular Branch: A Case Report and Current Trends in Management","volume":"3","author":"Rai","year":"2016","journal-title":"Int. J. Contemp. Med. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0030-4220(68)90322-8","article-title":"Localized odontalgia occurring during herpes zoster of the maxillary division of the fifth cranial nerve: Report of a case","volume":"26","author":"Verbin","year":"1968","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.joen.2017.04.021","article-title":"The role of varicella zoster virus in the development of periapical pathoses and root resorption: A systematic review","volume":"43","author":"Jakovljevic","year":"2017","journal-title":"J. Endod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.joen.2015.02.014","article-title":"Varicella zoster virus and internal root resorption: A case report","volume":"41","author":"Talebzadeh","year":"2015","journal-title":"J. Endod."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/0030-4220(84)90156-7","article-title":"An unusual oral complication of herpes zoster infection","volume":"57","author":"Smith","year":"1984","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/0030-4220(92)90005-B","article-title":"Maxillary osteomyelitis and spontaneous tooth exfoliation after herpes zoster","volume":"73","author":"Mintz","year":"1992","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/0278-2391(90)90020-3","article-title":"Tooth exfoliation and necrosis of the mandible\u2014A rare complication following trigeminal herpes zoster: Report of a case","volume":"48","author":"Muto","year":"1990","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Huang, K., Wang, Y., Huang, Y., Han, S., Yang, Y., Qu, P., Liang, B., Zhen, Q., Chen, W., and Lin, Y. (2024). Infection may play an important role in the pathogenesis of alveolar osteonecrosis following facial herpes zoster: A case report and literature review. BMC Oral Health, 24.","DOI":"10.1186\/s12903-024-04202-z"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.joms.2016.07.019","article-title":"Osteonecrosis of the jaw in the absence of antiresorptive or antiangiogenic exposure: A series of 6 cases","volume":"75","author":"Aghaloo","year":"2017","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/0030-4220(74)90128-5","article-title":"Necrosis of maxilla in patient with herpes zoster: Report of a case","volume":"37","author":"Hall","year":"1974","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/0007-117X(76)90057-3","article-title":"Dental complications of cytotoxic therapy in Hodgkin\u2019s disease\u2014A case report","volume":"13","author":"Vickery","year":"1976","journal-title":"Br. J. Oral Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/sj.bdj.4803994","article-title":"Tooth exfoliation and osteonecrosis of the jaw following herpes zoster","volume":"143","author":"Cooper","year":"1977","journal-title":"Br. Dent. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0300-9785(82)80060-4","article-title":"Tooth exfoliation, osteonecrosis of the jaw and neuralgia following herpes zoster of the trigeminal nerve","volume":"11","author":"Schwartz","year":"1982","journal-title":"Int. J. Oral Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0022-3476(85)80469-8","article-title":"Tooth exfoliation and osteonecrosis of the maxilla after trigeminal herpes zoster","volume":"106","author":"Garty","year":"1985","journal-title":"J. Pediatr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1097\/00007611-198608000-00028","article-title":"Trigeminal herpes zoster causing mandibular osteonecrosis and spontaneous tooth exfoliation","volume":"79","author":"Manz","year":"1986","journal-title":"South. Med. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/0278-2391(87)90126-1","article-title":"Spontaneous tooth exfoliation and osteonecrosis following a herpes zoster infection of the fifth cranial nerve","volume":"45","author":"Mostofi","year":"1987","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/S0278-2391(99)90497-4","article-title":"Herpes zoster infection of the maxilla: Case report","volume":"57","author":"Owotade","year":"1999","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1053\/joms.2003.50095","article-title":"A case of maxillary necrosis","volume":"61","author":"Pogrel","year":"2003","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1365-4632.2004.01837.x","article-title":"Mandibular alveolar bone necrosis after trigeminal herpes zoster","volume":"43","author":"Arikawa","year":"2004","journal-title":"Int. J. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0915-6992(04)80034-7","article-title":"Alveolar osteonecrosis of the mandible after varicella zoster infection of the trigeminal nerve","volume":"16","author":"Yamamoto","year":"2004","journal-title":"Asian J. Oral Maxillofac. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1097\/01.aids.0000194803.89540.a8","article-title":"Alveolar bone necrosis and tooth exfoliation secondary to herpes zoster in the setting of HIV\/AIDS","volume":"19","author":"McEachen","year":"2005","journal-title":"Aids"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1601-0825.2006.01230.x","article-title":"Herpes zoster in HIV infection with osteonecrosis of the jaw and tooth exfoliation","volume":"12","author":"Siwamogstham","year":"2006","journal-title":"Oral Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1308\/135576106777795527","article-title":"Spontaneous tooth exfoliation, maxillary osteomyelitis and facial scarring following trigeminal herpes zoster infection","volume":"13","author":"Pillai","year":"2006","journal-title":"Prim. Dent. Care"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.tripleo.2005.06.022","article-title":"Mandibular osteomyelitis and tooth exfoliation following zoster-CMV co-infection","volume":"101","author":"Meer","year":"2006","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontology"},{"key":"ref_37","first-page":"106","article-title":"Alveolar bone necrosis and spontaneous tooth exfoliation in an HIV-seropositive subject with Herpes Zoster: Case report","volume":"63","author":"Feller","year":"2008","journal-title":"S. Afr. Dent. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"52","DOI":"10.5466\/ijoms.8.52","article-title":"An Unusual Case of Osteonecrosis and Spontaneous Tooth Exfoliation Following Trigeminal Herpes Zoster in a HIV Seropositive Patient","volume":"8","author":"Kamarthi","year":"2009","journal-title":"Int. J. Oral-Med. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s12663-009-0046-3","article-title":"Ramsay-Hunt syndrome complicating osteonecrosis of edentulous maxilla and mandible: Report of a rare case","volume":"8","author":"Badjate","year":"2009","journal-title":"J. Maxillofac. Oral Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"177","DOI":"10.5125\/jkaoms.2012.38.3.177","article-title":"Alveolar bone necrosis and spontaneous tooth exfoliation associated with trigeminal herpes zoster: A report of three cases","volume":"38","author":"Kim","year":"2012","journal-title":"J. Korean Assoc. Oral Maxillofac. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10006-011-0303-8","article-title":"Maxillary osteonecrosis and spontaneous teeth exfoliation following herpes zoster","volume":"16","author":"Lambade","year":"2012","journal-title":"Oral Maxillofac. Surg."},{"key":"ref_42","first-page":"125","article-title":"Herpes zoster leading to viral osteomyelitis or neuralgia inducing cavitational osteonecrosis?\u2013A case report and review of literature","volume":"2","author":"Asha","year":"2014","journal-title":"Int. J. Sci. Stud."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/QAD.0000000000000122","article-title":"Mandibular osteonecrosis and dental exfoliation after trigeminal zoster in an HIV-infected patient: Case report and review of the literature","volume":"28","author":"Cloarec","year":"2014","journal-title":"Aids"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1974.e1","DOI":"10.1016\/j.joms.2014.05.004","article-title":"Mandibular osteonecrosis and Ramsay Hunt syndrome following a case of herpes zoster","volume":"72","author":"Rudd","year":"2014","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_45","unstructured":"Tabrizi, R., Nazhvani, A.D., Vahedi, A., Gholami, M., Zare, R., and Parsa, R.E. (2014). Herpes zoster induced osteomyelitis in the immunocompromised patients: A 10-year multicenter study. J. Dent., 15."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4103\/0972-1363.167126","article-title":"Mandibular osteonecrosis and teeth exfoliation after herpes zoster infection in an HIV-inflicted individual","volume":"27","author":"Arora","year":"2015","journal-title":"J. Indian Acad. Oral Med. Radiol."},{"key":"ref_47","unstructured":"Patil, S., and Al Zarea, B. (2015). Spontaneous exfoliation and osteonecrosis following herpes zoster infection in an HIV-seropositive subject: A case report. Austin J. Dent., 2."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"357","DOI":"10.5125\/jkaoms.2015.41.6.357","article-title":"Mandibular osteonecrosis following herpes zoster infection in the mandibular branch of the trigeminal nerve: A case report and literature review","volume":"41","author":"Song","year":"2015","journal-title":"J. Korean Assoc. Oral Maxillofac. Surg."},{"key":"ref_49","first-page":"369","article-title":"Herpes Zoster Induced Alveolar Bone Necrosis in Immunocompromised Patients; Two Case Reports","volume":"28","author":"Gholami","year":"2016","journal-title":"Iran. J. Otorhinolaryngol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Faure, E., Engels-Deutsch, M., Paraschiv, E.-A., G\u00e9rard, E., and Curien, R. (2021). Mandibular osteonecrosis following herpes zoster infection: Report of a rare case with a literature review. Clin. Case Rep., 9.","DOI":"10.1002\/ccr3.4196"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"220","DOI":"10.4103\/ams.ams_42_23","article-title":"Delayed Presentation of Mandibular Osteonecrosis Following Herpes Zoster Infection-A Case Report","volume":"13","author":"Chatterjee","year":"2023","journal-title":"Ann. Maxillofac. Surg."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/6\/883\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:49:13Z","timestamp":1760107753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/6\/883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,28]]},"references-count":51,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["medicina60060883"],"URL":"https:\/\/doi.org\/10.3390\/medicina60060883","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,28]]}}}