{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:09:37Z","timestamp":1782486577423,"version":"3.54.5"},"reference-count":29,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: The present systematic review and meta-analysis were conducted to evaluate and compare the long-term clinical outcomes of immediate implants placed into fresh sockets with and without periapical pathology. Materials and Methods: After the search and review of the literature in the electronic databases, 109 publications were achieved. The titles and abstracts of 66 publications were screened. After the evaluation of the full text of 22 publications, based on the inclusion criteria, six controlled clinical studies were included in this systematic review and meta-analysis. Results: The statistical calculation showed no heterogeneity among the studies included. The implant survival was 99.6% in the test (socket with periapical pathology) and control (socket without periapical pathology) groups of all the clinical trials. The results of the meta-analysis showed no statistically significant difference between test and control groups regarding the marginal bone level and the width of keratinized mucosa in all the studies. Other parameters indicating plaque level, bleeding on probing, and gingival recession also did not differ between test and control groups at the final follow-up in nearly all studies. Conclusions: Within the limitation of this systemic review and meta-analysis, the obtained data suggest that implants immediately placed into the extraction sockets of teeth exhibiting periapical pathology can be successfully osseointegrated for an extended period.<\/jats:p>","DOI":"10.3390\/medicina60060893","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T13:32:55Z","timestamp":1716903175000},"page":"893","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of Immediate Implantation into the Socket with and without Periapical Pathology: Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"60","author":[{"given":"Alma","family":"Pranckeviciene","sequence":"first","affiliation":[{"name":"Departament of Dental and Oral Pathology, Lithuanian University of Health Sciences, Mickeviciaus 9, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Vaitkeviciene","sequence":"additional","affiliation":[{"name":"Departament of Dental and Oral Pathology, Lithuanian University of Health Sciences, Mickeviciaus 9, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Siudikiene","sequence":"additional","affiliation":[{"name":"Departament of Dental and Oral Pathology, Lithuanian University of Health Sciences, Mickeviciaus 9, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skaiste","family":"Poskeviciene","sequence":"additional","affiliation":[{"name":"Departament of Dental and Oral Pathology, Lithuanian University of Health Sciences, Mickeviciaus 9, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4417-3221","authenticated-orcid":false,"given":"Vita","family":"Maciulskiene-Visockiene","sequence":"additional","affiliation":[{"name":"Departament of Dental and Oral Pathology, Lithuanian University of Health Sciences, Mickeviciaus 9, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"ref_1","first-page":"E720","article-title":"Immediate post-extraction implants placed in acute periapical infected sites with immediate prosthetic provisionalization: A 1-year prospective cohort study","volume":"25","year":"2020","journal-title":"Med. 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