{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:53:31Z","timestamp":1791986011690,"version":"4.4.0"},"reference-count":32,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Changes in activities of daily living (ADL) and quality of life (QOL) of patients with bone metastasis who underwent surgical treatment through Bone Metastasis Cancer Boards (BMCBs), a recent multidisciplinary approach for managing bone metastases, have been reported; however, no reports exist on patients who undergo conservative treatment. In this study, we aimed to evaluate these patients\u2019 ADL and QOL and examine the factors influencing changes in these parameters. Materials and Methods: We retrospectively reviewed 200 patients with bone metastases who underwent conservative therapy through BMCBs between 2013 and 2021. A reassessment was conducted within 2\u20138 weeks after the initial assessment. Patients\u2019 background and changes in performance status (PS), Barthel Index (BI), EuroQol five-dimension (EQ-5D) scores, and Numerical Rating Scale (NRS) scores were initially assessed. Furthermore, we categorized patients into two groups based on improvements or deteriorations in ADL and QOL and performed comparative analyses. Results: Significant improvements in EQ-5D (0.57 \u00b1 0.02 versus [vs.] 0.64 \u00b1 0.02), NRS max (5.21 \u00b1 0.24 vs. 3.56 \u00b1 0.21), and NRS average (2.98 \u00b1 0.18 vs. 1.85 \u00b1 0.13) scores were observed between the initial assessment and reassessment (all p &lt; 0.001). PS (1.84 \u00b1 0.08 vs. 1.72 \u00b1 0.08) and BI (83.15 \u00b1 1.68 vs. 84.42 \u00b1 1.73) also showed improvements (p = 0.06, and 0.054, respectively). In addition, spinal cord paralysis (odds ratio [OR]: 3.69, p = 0.049; OR: 8.42, p &lt; 0.001), chemotherapy (OR: 0.43, p = 0.02; OR: 0.25, p = 0.007), and NRS average scores (OR: 0.38, p = 0.02; OR: 0.14, p &lt; 0.001) were independent factors associated with ADL and QOL. Conclusions: Patients with bone metastases who underwent conservative treatment through BMCBs exhibited an increase in QOL without a decline in ADL. The presence of spinal cord paralysis, absence of chemotherapy, and poor pain control were associated with a higher risk of deterioration in ADL and QOL.<\/jats:p>","DOI":"10.3390\/medicina60060906","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T12:19:46Z","timestamp":1717417186000},"page":"906","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of Changes in Activities of Daily Living and Quality of Life of Patients with Bone Metastasis Who Underwent Conservative Therapy through Bone Metastasis Cancer Boards"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3452-5557","authenticated-orcid":false,"given":"Yasumitsu","family":"Fujii","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Kobe University Hospital 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"},{"name":"Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4123-0286","authenticated-orcid":false,"given":"Ryo","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Kobe University Hospital 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7363-655X","authenticated-orcid":false,"given":"Ryoga","family":"Kashima","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Kobe University Hospital 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"},{"name":"Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Saho","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Kobe University Hospital 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"},{"name":"Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3835-3154","authenticated-orcid":false,"given":"Hirokazu","family":"Onishi","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Kobe University Hospital 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5938-8375","authenticated-orcid":false,"given":"Tsuyoshi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Kobe University Hospital 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Kobe University Hospital 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"},{"name":"Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5360-5618","authenticated-orcid":false,"given":"Yoshiki","family":"Takeoka","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5688-7673","authenticated-orcid":false,"given":"Naomasa","family":"Fukase","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4006-037X","authenticated-orcid":false,"given":"Kenichiro","family":"Kakutani","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3708-4095","authenticated-orcid":false,"given":"Toshihiro","family":"Akisue","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences 7-10-2, Tomogaoka, Suma-ku, Kobe 654-0142, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitada","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Kobe University Hospital 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"},{"name":"Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00776-004-0788-1","article-title":"Metastatic bone disease: Pathogenesis and new strategies for treatment","volume":"9","author":"Uchida","year":"2004","journal-title":"J. Orthop. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0030-5898(05)70171-1","article-title":"Incidence, location, and diagnostic evaluation of metastatic bone disease","volume":"31","author":"Hage","year":"2000","journal-title":"Orthop. Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s10195-015-0344-0","article-title":"Bone metastases of unknown origin: Epidemiology and principles of management","volume":"16","author":"Piccioli","year":"2015","journal-title":"J. Orthop. Traumatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"482","DOI":"10.21037\/atm.2020.03.55","article-title":"Incidence of patients with bone metastases at diagnosis of solid tumors in adults: A large population-based study","volume":"8","author":"Huang","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/2192568217694016","article-title":"Spine stereotactic body radiotherapy: Indications, outcomes, and points of caution","volume":"7","author":"Tseng","year":"2017","journal-title":"Glob. Spine J."},{"key":"ref_6","first-page":"148","article-title":"Orthopaedic management of spinal metastases","volume":"312","author":"Hosono","year":"1995","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6243s","DOI":"10.1158\/1078-0432.CCR-06-0931","article-title":"Clinical features of metastatic bone disease and risk of skeletal morbidity","volume":"12","author":"Coleman","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1634\/theoncologist.9-90004-14","article-title":"Bisphosphonates: Clinical experience","volume":"9","author":"Coleman","year":"2004","journal-title":"Oncologist"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1002\/cncr.22678","article-title":"Economic burden of metastatic bone disease in the U.S. Cancer","volume":"109","author":"Schulman","year":"2007","journal-title":"Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/ctrv.2000.0210","article-title":"Metastatic bone disease: Clinical features, pathophysiology and treatment strategies","volume":"27","author":"Coleman","year":"2001","journal-title":"Cancer Treat. Rev."},{"key":"ref_11","first-page":"121","article-title":"Bone and cancer: The osteoncology","volume":"10","author":"Ibrahim","year":"2013","journal-title":"Clin. Cases Miner. Bone Metab."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1007\/s00520-019-4635-5","article-title":"Ten-year experience of the multidisciplinary Osteoncology Center","volume":"27","author":"Bongiovanni","year":"2019","journal-title":"Support. Care Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1007\/s10924-022-02615-x","article-title":"Preparation and in vitro osteogenic evaluation of biomimetic hybrid nanocomposite scaffolds based on gelatin\/plasma rich in growth factors (PRGF) and lithium-doped 45s5 bioactive glass nanoparticles","volume":"31","author":"Farmani","year":"2023","journal-title":"J. Polym. Environ."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Kimura, T. (2018). Multidisciplinary approach for bone metastasis: A review. Cancers, 10.","DOI":"10.3390\/cancers10060156"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"100352","DOI":"10.1016\/j.jbo.2021.100352","article-title":"Surgical outcomes of metastatic bone tumors in the extremities (Surgical outcomes of bone metastases)","volume":"27","author":"Hara","year":"2021","journal-title":"J. Bone Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Miyazaki, K., Kanda, Y., Sakai, Y., Yoshikawa, R., Yurube, T., Takeoka, Y., Hara, H., Akisue, T., Kuroda, R., and Kakutani, K. (2023). Effect of Bone Metastasis Cancer Board on Spinal Surgery Outcomes: A retrospective study. Medicina, 59.","DOI":"10.3390\/medicina59122087"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s10585-019-09983-0","article-title":"Factors related to the quality of life in patients with bone metastases","volume":"36","author":"Shinoda","year":"2019","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/cam4.292","article-title":"New prognostic factors and scoring system for patients with skeletal metastasis","volume":"3","author":"Katagiri","year":"2014","journal-title":"Cancer Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.suronc.2013.02.008","article-title":"Insight opinion to surgically treated metastatic bone disease: Scandinavian Sarcoma Group Skeletal Metastasis Registry report of 1195 operated skeletal metastasis","volume":"22","author":"Ratasvuori","year":"2013","journal-title":"Surg. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/00016470410001708270","article-title":"The Scandinavian Sarcoma Group skeletal metastasis register: Survival after surgery for bone metastases in the pelvis and extremities","volume":"75","author":"Hansen","year":"2004","journal-title":"Acta Orthop. Scand. Suppl."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.21037\/apm-21-3909","article-title":"Imaging features inferring symptom onset due to spinal metastasis progression: A preliminary study","volume":"11","author":"Ando","year":"2022","journal-title":"Ann. Palliat. Med."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kakutani, K., Kanda, Y., Yurube, T., Takeoka, Y., Miyazaki, K., Ohnishi, H., Matsuo, T., Ryu, M., Kuroshima, K., and Kumagai, N. (2023). The identification of risk factors for symptomatic spinal metastasis onset: A prospective cohort study of 128 asymptomatic spinal metastasis patients. Cancers, 15.","DOI":"10.3390\/cancers15041251"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Kakutani, K., Sakai, Y., Zhang, Z., Yurube, T., Takeoka, Y., Kanda, Y., Miyazaki, K., Ohnishi, H., Matsuo, T., and Ryu, M. (2022). Survival rate after palliative surgery alone for symptomatic spinal metastases: A prospective cohort study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11216227"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1302\/0301-620X.102B12.BJJ-2020-0566.R1","article-title":"Prospective cohort study of surgical outcome for spinal metastases in patients aged 70 years or older","volume":"102\u2013B","author":"Kanda","year":"2020","journal-title":"Bone Jt. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3747\/co.21.1989","article-title":"The role of palliative chemotherapy in hospitalized patients","volume":"21","author":"Ali","year":"2014","journal-title":"Curr. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.clcc.2014.09.010","article-title":"The effects of palliative chemotherapy in metastatic colorectal cancer patients with an ECOG performance status of 3 and 4","volume":"14","author":"Marques","year":"2015","journal-title":"Clin. Color. Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1200\/JCO.2010.33.1744","article-title":"American society of clinical oncology statement: Toward individualized care for patients with advanced cancer","volume":"29","author":"Peppercorn","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1200\/JCO.2012.42.8375","article-title":"American Society of Clinical Oncology identifies five key opportunities to improve care and reduce costs: The top five list for oncology","volume":"30","author":"Schnipper","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1080\/0284186X.2020.1819562","article-title":"The role of chemotherapy in patients with small cell lung cancer and poor performance status","volume":"59","author":"Noronha","year":"2020","journal-title":"Acta Oncol."},{"key":"ref_30","first-page":"20220022","article-title":"Clinical outcome of patients with bone metastases in a convalescent Rehabilitation Ward: A case series of six patients","volume":"7","author":"Kobayashi","year":"2022","journal-title":"PRM"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1684\/bdc.2013.1851","article-title":"Multidisciplinary meetings dedicated to bone metastases: A historical perspective and rationale","volume":"100","author":"Vieillard","year":"2013","journal-title":"Bull. Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.jos.2021.11.003","article-title":"Involvement of orthopaedic surgeons for cancer patients in orthopaedic training facilities certified by the Japanese Orthopaedic Association\u2014A nationwide survey","volume":"28","author":"Morioka","year":"2023","journal-title":"J. Orthop. Sci."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/6\/906\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:50:38Z","timestamp":1760107838000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/6\/906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,29]]},"references-count":32,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["medicina60060906"],"URL":"https:\/\/doi.org\/10.3390\/medicina60060906","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,29]]}}}