{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:18:03Z","timestamp":1775801883098,"version":"3.50.1"},"reference-count":49,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009687","name":"Wroclaw Medical University","doi-asserted-by":"publisher","award":["SUBZ.B150.22.100"],"award-info":[{"award-number":["SUBZ.B150.22.100"]}],"id":[{"id":"10.13039\/501100009687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: An oral lichen planus (OLP) chronic lesion refers to a group of oral potentially malignant disorders (OPMDs) that still lack a proper understanding from the point of view of relevant biomarkers for diagnostics and prognosis. The aim of the study was to assess the salivary histamine levels in patients with oral lichen planus lesions. Materials and Methods: The study included a group of 76 patients with oral lichen planus. General diseases and medication taken, smoking habits, severity of pain assessed using a visual analogue scale (VAS), oral hygiene status, and duration of OLP were evaluated. ELISA diagnostics for histamines in saliva levels were assessed. Results: The histamine levels in the OLP group were higher (0.468) in comparison with the control group (0.056), without a statistically significant value p = 0.090 (Mann\u2013Whitney U Test). The median age of 76 OLP patients was 63 years (min 22.0\u2013max. 81), with the biological sex being 80.3% females and 15 19.7% males. The average duration of OLP lesion presence was 29.4 months (SD 37.1) and the median value was 14.5 months. The median of the VAS was 3.0. OLP assessment in accordance with the Malhotra methodology showed the highest frequency\u201430.3% for only two of the point areas involved and 17.1% for three points. Clinical assessment of the different OLP grades, severity, and oral site involvement and the VAS in correlation with histamine salivary levels showed a lack of statistical significance in the investigated population. Conclusions: Undertaking further research could provide further possibilities for searching for general factors in OLP development.<\/jats:p>","DOI":"10.3390\/medicina60071038","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T10:10:07Z","timestamp":1719310207000},"page":"1038","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Salivary Histamine Levels in Patients with Oral Lichen Planus Lesions"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4684-5722","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Radwan-Oczko","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Wroc\u0142aw Medical University, ul. Krakowska 26, 50-425 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Rybi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Wroc\u0142aw Medical University, ul. Krakowska 26, 50-425 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Mierzwicka","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Isotope Treatment, Wybrze\u017ce L. Pasteura 4, 50-367 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4745-2560","authenticated-orcid":false,"given":"Irena","family":"Du\u015b-Ilnicka","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Wroc\u0142aw Medical University, ul. Krakowska 26, 50-425 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Smolinska, S., Winiarska, E., Globinska, A., and Jutel, M. (2022). Histamine: A Mediator of Intestinal Disorders\u2014A Review. Metabolites, 12.","DOI":"10.3390\/metabo12100895"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.anai.2010.08.005","article-title":"The basics of histamine biology","volume":"106","author":"Lieberman","year":"2011","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_3","first-page":"495","article-title":"Histamine as an immunomodulator","volume":"8","author":"Rossbach","year":"2010","journal-title":"J. Dtsch. Dermatol. Ges. J. Ger. Soc. 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