{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:14:00Z","timestamp":1760145240208,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015042","name":"Riga Stradi\u0146\u0161 University","doi-asserted-by":"publisher","award":["6-DN-20\/1\/2024"],"award-info":[{"award-number":["6-DN-20\/1\/2024"]}],"id":[{"id":"10.13039\/501100015042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Mammary gland surgery has become very common, but there are complications of these operations, including the concept of breast implant illness (BII) in women with silicone gel breast implants (SBI), who suffer from various symptoms such as myalgia, arthralgia, fatigue, fever, dry eyes, or dry mouth. Silicone biomaterials are synthetic polymers that have their own physical and chemical properties and can exert their effect at the site of use and possibly on the general status of the body, causing inflammation and oxidative stress signs. The aim of the study was to examine components of the blood antioxidant system (AOS) of the mastopexy and breast augmentation patients before the operation, on the first post-op day, and 6 months after surgery. Materials and Methods: Healthy breast surgery patients (women aged 31 to 60 years without visible pathologies) were selected for the study and formed 2 groups: breast lift\u2014mastopexy without silicone biomaterials (I group, 30 patients) and breast augmentation using silicone biomaterials (II group, 28 patients). All patients underwent standard preoperative tests. Glutathione peroxidase (GPxSe) and gamma-glutamyl transferase (GGT) in blood, selenium (Se), selenium protein P (SelPP), and total antioxidant status (TAS) in plasma were measured as AOS parameters. The concentration of vitamin D was also determined. A total of 174 blood tests were performed. Results: Overall, there were no differences in both groups in measured antioxidant system indicators over time; neither changes in objective nor subjective status were observed. However, baseline activity of GPxSe was relatively high but restored to normal values 6 months after surgery. In the mastopexy group, GPxSe decreased from 12,961.7 U\/L by 18.9% to 10,513.4 U\/L, and in the breast augmentation group, from 15,505.0 U\/L by 25.1% to 11,265.5 U\/L, which is a decrease of 18.9% and 25.1%, respectively. The patients did not note any complaints; other indicators of standard biochemical tests were within normal limits. Conclusions: The two types of surgical interventions, breast mastopexy and augmentation of the mammary glands, do not significantly impact blood AOS and are physiological in nature.<\/jats:p>","DOI":"10.3390\/medicina60071046","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T07:20:06Z","timestamp":1719386406000},"page":"1046","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antioxidant Status in Patients after Breast Mastopexy and Augmentation"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7694-6570","authenticated-orcid":false,"given":"Kirils","family":"Jur\u0161evi\u010ds","sequence":"first","affiliation":[{"name":"Department of Doctoral Studies, Riga Stradi\u0146\u0161 University, LV1007 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduards","family":"Jur\u0161evi\u010ds","sequence":"additional","affiliation":[{"name":"Clinic of Aesthetic Medicine of Medical Doctor Edward Yurshevich, LV1010 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je\u013cena","family":"Krasi\u013c\u0146ikova","sequence":"additional","affiliation":[{"name":"Department of Human Physiology and Biochemistry, R\u012bga Stradi\u0146\u0161 University, LV1007 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3726-8724","authenticated-orcid":false,"given":"Andrejs","family":"\u0160\u0137esters","sequence":"additional","affiliation":[{"name":"Scientific Laboratory of Biochemistry, Riga Stradi\u0146\u0161 University, LV1067 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0970-2127","authenticated-orcid":false,"given":"Anna","family":"Lece","sequence":"additional","affiliation":[{"name":"Scientific Laboratory of Biochemistry, Riga Stradi\u0146\u0161 University, LV1067 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4044-8750","authenticated-orcid":false,"given":"Ingus","family":"Skadi\u0146\u0161","sequence":"additional","affiliation":[{"name":"Department of Biology and Microbiology, R\u012bga Stradi\u0146\u0161 University, LV1007 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1007\/s00266-021-02762-x","article-title":"Effects of Silicone Breast Implants on Human Cell Types In Vitro: A Closer Look on Host and Implant","volume":"46","author":"Colaris","year":"2022","journal-title":"Aesthetic Plast. 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