{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T12:13:14Z","timestamp":1779883994942,"version":"3.53.1"},"reference-count":34,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy \u201cIuliu Ha\u021bieganu\u201d Cluj-Napoca","award":["PCD\/1300\/65\/2017"],"award-info":[{"award-number":["PCD\/1300\/65\/2017"]}]},{"name":"2020 Development Fund of the Babe\u0219-Bolyai University","award":["PCD\/1300\/65\/2017"],"award-info":[{"award-number":["PCD\/1300\/65\/2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: irregularities in the growth and development of the jawbones can lead to misalignments of maxillary and mandibular structures, a complex condition known as skeletal malocclusion, one of the most common oral health problems. Skeletal malocclusions, particularly Class II and Class III, can significantly affect facial appearance, chewing efficiency, speech, and overall oral health, often requiring orthodontic treatment or surgery to correct. These dentofacial anomalies are influenced by genetic and environmental factors and exhibit diverse phenotypic expressions. Materials and Methods: in this study, we investigated the correlation between the rs7351083 SNP of the FBN3 gene that encodes a member of the fibrillin protein family and malocclusion risk in a group of 57 patients from Romania. Results: the results shed light on the relationship between the selected genetic marker and the investigated dentofacial disorder, revealing a positive association between the reference allele (A) and Class II and that the alternate allele (G) is associated with Class III. Conclusions: cephalometric analysis revealed no significant differences among genotypes, suggesting that while genetic factors are implicated in malocclusion, they may not directly affect cephalometric parameters or that the sample size was too small to detect these differences. The discovery of an A &gt; T transversion in one individual with a Class II deformity underscores the genetic diversity within the population and the necessity of comprehensive genotyping to uncover rare genetic variants that might influence craniofacial development and the risk of malocclusion. This study highlights the need for larger studies to confirm these preliminary associations.<\/jats:p>","DOI":"10.3390\/medicina60071061","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T11:19:02Z","timestamp":1719487142000},"page":"1061","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Genetic Insights into Skeletal Malocclusion: The Role of the FBN3 rs7351083 SNP in the Romanian Population"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0184-397X","authenticated-orcid":false,"given":"Adina Maria","family":"Top\u00e2rcean","sequence":"first","affiliation":[{"name":"Oral Rehabilitation Department, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, Victor Babe\u0219 8 Street, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3712-4336","authenticated-orcid":false,"given":"Arina","family":"Acatrinei","sequence":"additional","affiliation":[{"name":"Molecular Biology Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babe\u0219-Bolyai University, Treboniu Laurian 42 Street, 400271 Cluj-Napoca, Romania"},{"name":"Doctoral School of Agricultural Engineering Sciences, University of Agricultural Sciences and Veterinary Medicine, Calea M\u0103n\u0103\u0219tur 3-5 Street, 400372 Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6152-8832","authenticated-orcid":false,"given":"Ioana","family":"Rusu","sequence":"additional","affiliation":[{"name":"Molecular Biology Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babe\u0219-Bolyai University, Treboniu Laurian 42 Street, 400271 Cluj-Napoca, Romania"},{"name":"Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babe\u0219-Bolyai University, Republicii nr 44 Street, 400015 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3377-593X","authenticated-orcid":false,"given":"Dana","family":"Fe\u0219til\u0103","sequence":"additional","affiliation":[{"name":"Department of Conservative Odontology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, \u201cIuliu Hatieganu\u201d Victor Babe\u0219 8 Street, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu Septimiu","family":"C\u00e2mpian","sequence":"additional","affiliation":[{"name":"Oral Rehabilitation Department, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, Victor Babe\u0219 8 Street, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2989-2941","authenticated-orcid":false,"given":"Beatrice","family":"Kelemen","sequence":"additional","affiliation":[{"name":"Molecular Biology Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babe\u0219-Bolyai University, Treboniu Laurian 42 Street, 400271 Cluj-Napoca, Romania"},{"name":"Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babe\u0219-Bolyai University, Republicii nr 44 Street, 400015 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1616-6518","authenticated-orcid":false,"given":"Mircea Constantin Dinu","family":"Ghergie","sequence":"additional","affiliation":[{"name":"Department of Conservative Odontology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, \u201cIuliu Hatieganu\u201d Victor Babe\u0219 8 Street, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jobcr.2021.10.012","article-title":"Malocclusion and occlusal traits among dental and nursing students of Seven North-East states of India","volume":"12","author":"Devi","year":"2022","journal-title":"J. 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