{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:12:37Z","timestamp":1760145157837,"version":"build-2065373602"},"reference-count":11,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taoyuan Armed Forces General Hospital","award":["TYAFGH-D-113032"],"award-info":[{"award-number":["TYAFGH-D-113032"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Herlyn\u2013Werner\u2013Wunderlich (HWW) syndrome is characterized by obstructed hemivagina and ipsilateral renal anomaly, a rare congenital anomaly of the genitourinary tract, resulting from malformations of the renal tract associated with M\u00fcllerian duct anomalies. The initial symptoms of HWW frequently present after menarche and may be nonspecific, leading to a delayed diagnosis. We presented a 19-year-old female with 3-year hematuria and abdominal pain. The final diagnosis of HWW syndrome with a rare vesicovaginal fistula was made. The treatment of HWW syndrome typically involves surgical intervention. The primary treatment is resection or removal of the obstructed vaginal septum. The patient underwent excision of vaginal septum and vaginal reconstruction via hysteroscopy, as well as repair of the vesicovaginal fistula. The patient improved well after surgery and fully recovered without sequelae after 3 months. In addition, unilateral renal agenesis is one of congenital abnormalities of the kidney and urinary tract, which are the most frequent cause of chronic kidney disease (CKD) in children. This report describes a patient of HWW syndrome with rarely combined vesicovaginal fistula, and highlights the importance of early recognition and management to prevent associated complications.<\/jats:p>","DOI":"10.3390\/medicina60071081","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T04:53:27Z","timestamp":1719809607000},"page":"1081","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Herlyn\u2013Werner\u2013Wunderlich Syndrome Complicated with Vesicovaginal Fistula: A Rare Case Report"],"prefix":"10.3390","volume":"60","author":[{"given":"Ruei-Lin","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Taoyuan Armed Forces General Hospital, Taoyuan 325, Taiwan"},{"name":"Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Kuen","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, Taoyuan Armed Forces General Hospital, Taoyuan 325, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Hsien","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, Taoyuan Armed Forces General Hospital, Taoyuan 325, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenq-Shyong","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Taoyuan Armed Forces General Hospital, Taoyuan 325, Taiwan"},{"name":"Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan"},{"name":"Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital Songshan Branch, National Defense Medical Center, Taipei 114, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang-Seng","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, Taoyuan Armed Forces General Hospital, Taoyuan 325, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Jen","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Taoyuan Armed Forces General Hospital, Taoyuan 325, Taiwan"},{"name":"Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan"},{"name":"Department of Life Sciences, National Central University, Taoyuan 320, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,1]]},"reference":[{"key":"ref_1","first-page":"340","article-title":"Simultaneous occurrence of an open Gartner-duct cyst, a homolateral aplasia of the kidney and a double uterus as a typical syndrome of abnormalities","volume":"31","author":"Herlyn","year":"1971","journal-title":"Geburtshilfe Frauenheilkd."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Panaitescu, A.M., Peltecu, G., and Gic\u0103, N. (2022). Herlyn-Werner-Wunderlich Syndrome: Case Report and Review of the Literature. Diagnostics, 12.","DOI":"10.3390\/diagnostics12102466"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.radcr.2022.02.017","article-title":"The Herlyn-Werner-Wunderlich (HWW) syndrome\u2014A case report with radiological review","volume":"17","author":"Hayat","year":"2022","journal-title":"Radiol. Case Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e223","DOI":"10.52225\/narra.v3i2.223","article-title":"Herlyn-Werner-Wunderlich syndrome: Challenges in diagnosis and management","volume":"3","author":"Roziana","year":"2023","journal-title":"Narra J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s13224-015-0707-8","article-title":"Herlyn-Werner-Wunderlich Syndrome","volume":"66","author":"Mittal","year":"2016","journal-title":"J. Obstet. Gynaecol. India"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"102843","DOI":"10.1016\/j.amsu.2021.102843","article-title":"A challenging diagnosis and management of Herlyn-Werner-Wunderlich Syndrome in low-resource Settings: A case report complicated with hydronephrosis","volume":"70","author":"Jomaa","year":"2021","journal-title":"Ann. Med. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/cga.12489","article-title":"Preoperative MRI presentations of Herlyn-Werner-Wunderlich syndrome","volume":"62","author":"Zhang","year":"2022","journal-title":"Congenit. Anom."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"101911","DOI":"10.1016\/j.eucr.2021.101911","article-title":"Herlyn-Werner-Wunderlich syndrome with urethrovaginal fistula: A rare case report","volume":"40","author":"Adi","year":"2021","journal-title":"Urol. 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Nephrol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/7\/1081\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:08:33Z","timestamp":1760108913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/7\/1081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":11,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["medicina60071081"],"URL":"https:\/\/doi.org\/10.3390\/medicina60071081","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2024,7,1]]}}}