{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:45:16Z","timestamp":1790207116073,"version":"4.1.0"},"reference-count":64,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Emerging evidence is placing the Mediterranean diet (MD) in the spotlight as a potential dietary model that could benefit inflammatory bowel disease (IBD) patients in terms of prevention and progress of the disease. The main aim of the present study is to shed some light on the relationship between the adherence to the MD and the degree of disease activity, as well as the quality of life in patients with Crohn\u2019s disease (CD).\u00a0Materials and Methods: An administered questionnaire was used to assess and record a number of parameters, including recent medical and weight history, anthropometric characteristics, disease activity (in remission or active disease), and quality of life of both male and female CD patients. Moreover, the level of compliance of the participants to the Mediterranean diet model was evaluated and its relationship with disease activity and quality of life was investigated. Results: Adherence to the MD was significantly higher in patients with inactive disease than in those with active disease (p = 0.019). According to the correlation analysis conducted, adherence to the MD was negatively correlated with disease activity (p = 0.039) and positively correlated with quality of life (QoL) (p = 0.046) of the participants. Intake of fruits, vegetables, and dairy products was significantly higher in remission patients (p = 0.046, p = 0.001, p = 0.041, respectively). Conclusions: We conclude, according to the findings of the study, that adherence to the MD is associated with disease activity and QoL in patients with CD. Future research should focus on MD intervention studies on IBD patients in order to assess its effect on modulating disease activity\/course and related inflammatory biomarkers.<\/jats:p>","DOI":"10.3390\/medicina60071106","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T04:52:49Z","timestamp":1720414369000},"page":"1106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Relationship of Adherence to the Mediterranean Diet with Disease Activity and Quality of Life in Crohn\u2019s Disease Patients"],"prefix":"10.3390","volume":"60","author":[{"given":"Athanasios","family":"Migdanis","sequence":"first","affiliation":[{"name":"Nutrition and Dietetics Department, University of Thessaly, Argonafton 1C, 42132 Trikala, Greece"},{"name":"Faculty of Medicine, University of Thessaly, Viopolis Mezourlo, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Migdanis","sequence":"additional","affiliation":[{"name":"Nutrition and Dietetics Department, University of Thessaly, Argonafton 1C, 42132 Trikala, Greece"},{"name":"Faculty of Medicine, University of Thessaly, Viopolis Mezourlo, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikoleta D.","family":"Gkogkou","sequence":"additional","affiliation":[{"name":"MSc Program Nutrition in Health and Disease, Faculty of Medicine, University of Thessaly, Viopolis Mezourlo, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sousana K.","family":"Papadopoulou","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences and Dietetics, International Hellenic University, Nea Moudania, 57001 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2878-4831","authenticated-orcid":false,"given":"Constantinos","family":"Giaginis","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, University of the Aegean, Myrina, 81400 Lemnos, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2263-0436","authenticated-orcid":false,"given":"Athanasios","family":"Manouras","sequence":"additional","affiliation":[{"name":"Nutrition and Dietetics Department, University of Thessaly, Argonafton 1C, 42132 Trikala, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Anna","family":"Polyzou Konsta","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Hospital of Larissa, Viopolis Mezourlo, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7915-6064","authenticated-orcid":false,"given":"Rena I.","family":"Kosti","sequence":"additional","affiliation":[{"name":"Nutrition and Dietetics Department, University of Thessaly, Argonafton 1C, 42132 Trikala, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos A.","family":"Oikonomou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital of Larissa, Viopolis Mezourlo, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2026-9678","authenticated-orcid":false,"given":"Konstantinos","family":"Argyriou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital of Larissa, Viopolis Mezourlo, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyridon","family":"Potamianos","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Thessaly, Viopolis Mezourlo, 41110 Larissa, Greece"},{"name":"MSc Program Nutrition in Health and Disease, Faculty of Medicine, University of Thessaly, Viopolis Mezourlo, 41110 Larissa, Greece"},{"name":"Department of Gastroenterology, University Hospital of Larissa, Viopolis Mezourlo, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Kapsoritakis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Thessaly, Viopolis Mezourlo, 41110 Larissa, Greece"},{"name":"MSc Program Nutrition in Health and Disease, Faculty of Medicine, University of Thessaly, Viopolis Mezourlo, 41110 Larissa, Greece"},{"name":"Department of Gastroenterology, University Hospital of Larissa, Viopolis Mezourlo, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"ref_1","unstructured":"GBD 2017 Inflammatory Bowel Disease Collaborators (2020). 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