{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:50:14Z","timestamp":1788306614683,"version":"build-2803163510"},"reference-count":49,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: In this study, the effects of a six-week training program and various diets on subfatin, asprosin, irisin, leptin, ghrelin and the lipid profile were investigated in overweight women. Materials and Methods: A total of 78 women voluntarily participated in the study. Groups: The study was divided into eight groups: Healthy Control, Obese Control, Obese + Vegetarian, Obese + Ketogenic, Obese + Intermittent Fasting, Obese + Exercise + Vegetarian, Obese + Exercise + Ketogenic and Obese + Exercise + Intermittent Fasting. While there was no intervention in the healthy and obese control groups, the other groups followed predetermined exercise and diet programs for 6 weeks. Blood samples were taken from the participants in the research group twice (before and after the interventions). An autoanalyzer was used to determine the lipid profile in the blood samples taken, and the ELISA method was used to analyze other parameters. Results: Overall, a significant difference was found in the values of weight, BMI, subfatin, ghrelin, leptin, cholesterol, triglyceride, HDL and LDL as a result of the exercise and diet interventions (p &lt; 0.05). There was no significant difference in asprosin and irisin values (p &gt; 0.05). Conclusions: In conclusion, regular exercise and dietary interventions in obese women can regulate lipid profile, ghrelin, leptin and asprosin levels, and increasing irisin with exercise can activate lipid metabolism and support positive changes in lean mass.<\/jats:p>","DOI":"10.3390\/medicina60071118","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T15:22:05Z","timestamp":1720624925000},"page":"1118","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Leptin, Ghrelin, Irisin, Asprosin and Subfatin Changes in Obese Women: Effect of Exercise and Different Nutrition Types"],"prefix":"10.3390","volume":"60","author":[{"given":"Elif","family":"Bengin","sequence":"first","affiliation":[{"name":"Institute of Health Sciences, Faculty Sport Science, Firat University, Elazig 23200, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdurrahman","family":"K\u0131rtepe","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport, Faculty Sport Science, Firat University, Elazig 23200, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedat","family":"\u00c7\u0131nar","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport, Faculty Sport Science, Firat University, Elazig 23200, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taner","family":"Akbulut","sequence":"additional","affiliation":[{"name":"Department of Coaching Education, Faculty Sport Science, Firat University, Elazig 23200, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1902-4830","authenticated-orcid":false,"given":"Luca","family":"Russo","sequence":"additional","affiliation":[{"name":"eCampus University, 22060 Novedrate, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2156-6236","authenticated-orcid":false,"given":"\u0130sa","family":"Aydemir","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport, Faculty of Education, Hakkari University, Hakkari 30100, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polat","family":"Y\u00fccedal","sequence":"additional","affiliation":[{"name":"Department of Coaching Education, Faculty Sport Science, Munzur University, Tunceli 62100, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6162-3250","authenticated-orcid":false,"given":"S\u00fcleyman","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Firat University, Elazig 23200, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7144-7403","authenticated-orcid":false,"given":"Gian Mario","family":"Migliaccio","sequence":"additional","affiliation":[{"name":"Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Rome Open University, 00166 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2024). 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