{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:20:57Z","timestamp":1760145657793,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Chronic hepatitis C virus (HCV) infection is intricately linked with dysregulation of lipid metabolism. In particular, cholesterol plays a crucial role in HCV replication. Direct-acting antiviral agents (DAAs) therapy has revolutionized the hepatitis C treatment landscape, achieving high rates of sustained virological response (SVR). However, viral clearance comes with some alterations in lipid-related markers. This prospective study aimed to evaluate the impact of HCV clearance on lipid homeostasis and non-invasive liver fibrosis markers in hepatitis C patients treated with DAAs. Material and Methods: Fifty-two patients with varying degrees of fibrosis treated with DAAs therapy were evaluated at baseline and 24 weeks post-SVR. Lipid profiles and non-invasive liver fibrosis markers were assessed. Results: Our findings revealed an increase in total cholesterol, triglyceride, and LDLc (low-density lipoprotein cholesterol) levels at 24 weeks post-SVR, alongside an improvement in serum liver enzymes. Although improvements in liver stiffness were observed in non-invasive tests, there was an increase in lipid-related markers post-SVR. Conclusions: This suggests a potential increased cardiovascular risk despite improvements in liver function and fibrosis, highlighting the necessity for statin therapy in some cases and extended follow-ups for these patients. These findings underscore the importance of closely monitoring lipid profiles in chronic hepatitis C patients post-SVR, as well as the potential need for statin therapy to mitigate cardiovascular risk. Additionally, extended follow-up is essential to assess long-term outcomes and ensure the optimal management of these patients.<\/jats:p>","DOI":"10.3390\/medicina60081295","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T05:19:38Z","timestamp":1723439978000},"page":"1295","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prospective Assessment of Serum Lipid Alterations in Chronic Hepatitis C Patients Treated with Direct Acting Antivirals: Insights Six Months Post Sustained Virological Response"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3626-9857","authenticated-orcid":false,"given":"Oana","family":"Koppandi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Western University \u201cVasile Goldi\u0219\u201d of Arad, Revolu\u0163iei Boulevard 94, 310025 Arad, Romania"},{"name":"Multidisciplinary Doctoral School, Western University \u201cVasile Goldi\u0219\u201d of Arad, 310025 Arad, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Iov\u0103nescu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Western University \u201cVasile Goldi\u0219\u201d of Arad, Revolu\u0163iei Boulevard 94, 310025 Arad, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5336-5789","authenticated-orcid":false,"given":"Bogdan","family":"Miu\u021bescu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Square 2, 300041 Timi\u0219oara, Romania"},{"name":"Advanced Regional Research Center in Gastroenterology and Hepatology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timi\u0219oara, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandru C\u0103t\u0103lin","family":"Motofelea","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oana Maria","family":"Jig\u0103u","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Western University \u201cVasile Goldi\u0219\u201d of Arad, Revolu\u0163iei Boulevard 94, 310025 Arad, Romania"},{"name":"Multidisciplinary Doctoral School, Western University \u201cVasile Goldi\u0219\u201d of Arad, 310025 Arad, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea Iulia","family":"Papoi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Western University \u201cVasile Goldi\u0219\u201d of Arad, Revolu\u0163iei Boulevard 94, 310025 Arad, Romania"},{"name":"Multidisciplinary Doctoral School, Western University \u201cVasile Goldi\u0219\u201d of Arad, 310025 Arad, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3657-4546","authenticated-orcid":false,"given":"C\u0103lin","family":"Burciu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Western University \u201cVasile Goldi\u0219\u201d of Arad, Revolu\u0163iei Boulevard 94, 310025 Arad, Romania"},{"name":"Department of Gastroenterology and Hepatology, Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Square 2, 300041 Timi\u0219oara, Romania"},{"name":"Advanced Regional Research Center in Gastroenterology and Hepatology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timi\u0219oara, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5087-1611","authenticated-orcid":false,"given":"Eyad","family":"Gadour","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, King Abdulaziz Hospital-National Guard, Ahsa 31982, Saudi Arabia"},{"name":"Department of Internal Medicine, Faculty of Medicine, Zamzam University College, Khartoum 11113, Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deiana","family":"Vuletici","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Square 2, 300041 Timi\u0219oara, Romania"},{"name":"Advanced Regional Research Center in Gastroenterology and Hepatology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timi\u0219oara, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eftimie","family":"Miu\u021bescu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Western University \u201cVasile Goldi\u0219\u201d of Arad, Revolu\u0163iei Boulevard 94, 310025 Arad, Romania"},{"name":"Multidisciplinary Doctoral School, Western University \u201cVasile Goldi\u0219\u201d of Arad, 310025 Arad, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,10]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2017). 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