{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:13:51Z","timestamp":1785208431879,"version":"3.55.0"},"reference-count":76,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ewha Womans University Research Grant","award":["RS-2022-II220621"],"award-info":[{"award-number":["RS-2022-II220621"]}]},{"name":"Ewha Womans University Research Grant","award":["RS-2023-00262087"],"award-info":[{"award-number":["RS-2023-00262087"]}]},{"name":"Institute of Information &amp; communications Technology Planning &amp; Evaluation (IITP)","award":["RS-2022-II220621"],"award-info":[{"award-number":["RS-2022-II220621"]}]},{"name":"Institute of Information &amp; communications Technology Planning &amp; Evaluation (IITP)","award":["RS-2023-00262087"],"award-info":[{"award-number":["RS-2023-00262087"]}]},{"name":"Korean Evaluation Institute of Industrial Technology (KEIT)","award":["RS-2022-II220621"],"award-info":[{"award-number":["RS-2022-II220621"]}]},{"name":"Korean Evaluation Institute of Industrial Technology (KEIT)","award":["RS-2023-00262087"],"award-info":[{"award-number":["RS-2023-00262087"]}]},{"name":"Korean Health Industry Development Institute (KHIDI)","award":["RS-2022-II220621"],"award-info":[{"award-number":["RS-2022-II220621"]}]},{"name":"Korean Health Industry Development Institute (KHIDI)","award":["RS-2023-00262087"],"award-info":[{"award-number":["RS-2023-00262087"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Postural orthostatic tachycardia syndrome (POTS) is a complex condition marked by an atypical autonomic response to standing, leading to orthostatic intolerance and significant tachycardia without accompanying hypotension. In recent studies, a considerable number of individuals recovering from COVID-19 have been reported to experience POTS within 6 to 8 months post-infection. Key symptoms of POTS include fatigue, difficulty with orthostatic tolerance, tachycardia, and cognitive challenges. The underlying causes of POTS following COVID-19 remain unknown, with various theories proposed such as renin\u2013angiotensin\u2013aldosterone system (RAAS) dysregulation, hyperadrenergic reaction, and direct viral infection. Healthcare professionals should be vigilant for POTS in patients who have recovered from COVID-19 and are experiencing signs of autonomic dysfunction and use diagnostic procedures such as the tilt-up table test for confirmation. COVID-19-related POTS should be approached with a holistic strategy. Although many patients show improvement with initial non-drug treatments, for subjects who do not respond and exhibit more severe symptoms, medication-based therapies may be necessary. The current understanding of COVID-19-related POTS is limited, underscoring the need for more research to increase knowledge and enhance treatment approaches.<\/jats:p>","DOI":"10.3390\/medicina60081325","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T09:29:41Z","timestamp":1723714181000},"page":"1325","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Postural Orthostatic Tachycardia Syndrome Associated with COVID-19: A Narrative Review"],"prefix":"10.3390","volume":"60","author":[{"given":"Jung-Hyun","family":"Park","sequence":"first","affiliation":[{"name":"Ewha Womans University College of Medicine, Seoul 07804, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somin","family":"Park","sequence":"additional","affiliation":[{"name":"Ewha Womans University College of Medicine, Seoul 07804, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-Hye","family":"Kim","sequence":"additional","affiliation":[{"name":"Ewha Womans University College of Medicine, Seoul 07804, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonjin","family":"Lee","sequence":"additional","affiliation":[{"name":"Ewha Womans University College of Medicine, Seoul 07804, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0345-2278","authenticated-orcid":false,"given":"Yoonkyung","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mokdong Hospital, Ewha Womans University College of Medicine, Seoul 07985, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9937-762X","authenticated-orcid":false,"given":"Tae-Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul Hospital, Ewha Womans University College of Medicine, Seoul 07804, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41586-022-05522-2","article-title":"The WHO estimates of excess mortality associated with the COVID-19 pandemic","volume":"613","author":"Msemburi","year":"2023","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e1886","DOI":"10.1212\/WNL.0000000000200195","article-title":"Risk of COVID-19 Infection and of Severe Complications Among People with Epilepsy: A Nationwide Cohort Study","volume":"98","author":"Yoo","year":"2022","journal-title":"Neurology"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Chang, Y., Jeon, J., Song, T.J., and Kim, J. 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