{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T21:35:10Z","timestamp":1781904910683,"version":"3.54.5"},"reference-count":17,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T00:00:00Z","timestamp":1723852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Regional Development Fund according to the 2014\u20132020 Operational Programme for the European Union Funds\u2019 Investments","award":["01.2.2-CPVA-K-703"],"award-info":[{"award-number":["01.2.2-CPVA-K-703"]}]},{"name":"European Regional Development Fund according to the 2014\u20132020 Operational Programme for the European Union Funds\u2019 Investments","award":["01.2.2-CPVA-K-703-03-0025"],"award-info":[{"award-number":["01.2.2-CPVA-K-703-03-0025"]}]},{"name":"\u201cStrengthening of Activities of Competence Centers\u2019 and Innovation and Technology Transfer Centers\u201d under a grant agreement with the Central Project Management Agency","award":["01.2.2-CPVA-K-703"],"award-info":[{"award-number":["01.2.2-CPVA-K-703"]}]},{"name":"\u201cStrengthening of Activities of Competence Centers\u2019 and Innovation and Technology Transfer Centers\u201d under a grant agreement with the Central Project Management Agency","award":["01.2.2-CPVA-K-703-03-0025"],"award-info":[{"award-number":["01.2.2-CPVA-K-703-03-0025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Cardiac surgery is associated with various durations of cerebral autoregulation (CA) impairment and can significantly impact cognitive function. Cognitive functions such as memory, psychomotor speed, and attention are significantly impacted after cardiac surgery, necessitating prioritization of these areas in cognitive function tests. There is a lack of research connecting cerebral autoregulation impairment to specific cognitive function domains after cardiac surgery. This study aimed to determine if impaired cerebral autoregulation is associated with postoperative memory impairment and to test the hypothesis that the duration of this impairment affects the development of postoperative memory issues. Materials and Methods: A prospective study was conducted in 2021\u20132023. After approval of the Ethics Committee and with patient\u2019s written consent, 83 adult patients undergoing elective on-pump coronary artery bypass graft (CABG) surgery were enrolled. All patients were assessed for cognitive function 1 day before surgery using the Mini-Mental state examination (MMSE-2) test as a screening tool and the Hopkins Verbal Learning Test-Revised (HVLT-R) to assess memory specifically. To diagnose possible memory impairment (IM), all patients underwent a repeat assessment of cognitive function on the 7th\u201310th postoperative day. Cerebral autoregulation monitoring using transcranial Doppler was performed. Cerebral autoregulation status index (Mx) was recorded using Intensive Care Brain Monitoring System software, 9.1.5.23 (Cambridge, UK). Results: According to our research, the incidence of postoperative memory impairment is 30.1%. Temporary cerebral autoregulation impairment occurs in all patients undergoing elective in-pump CABG surgery. The duration of the single longest CA impairment event in seconds (LCAI) and the LCAI dose were higher in patients with postoperative memory impairment, p = 0.006 and p &lt; 0.007, respectively. Conclusions: Cerebral autoregulation impairment is important in developing memory loss after cardiac surgery. The duration and dose of the LCAI event are predictive of postoperative memory impairment.<\/jats:p>","DOI":"10.3390\/medicina60081337","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T03:43:28Z","timestamp":1724039008000},"page":"1337","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Association of Cerebral Autoregulation Dysfunction and Postoperative Memory Impairment in Cardiac Surgery Patients"],"prefix":"10.3390","volume":"60","author":[{"given":"Greta","family":"Kasputyt\u0117","sequence":"first","affiliation":[{"name":"Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 50162 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birut\u0117","family":"Kumpaitien\u0117","sequence":"additional","affiliation":[{"name":"Department of Disaster Medicine, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6095-6261","authenticated-orcid":false,"given":"Milda","family":"\u0160vag\u017edien\u0117","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 50162 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judita","family":"Andrejaitien\u0117","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 50162 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindaugas","family":"Gailiu\u0161as","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Surgery, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmundas","family":"\u0160irvinskas","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Surgery, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ar\u016bnas","family":"Gelmanas","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Hamarat","sequence":"additional","affiliation":[{"name":"Health Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edvinas","family":"Chaleckas","sequence":"additional","affiliation":[{"name":"Health Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5471-5645","authenticated-orcid":false,"given":"Vilma","family":"Putnynait\u0117","sequence":"additional","affiliation":[{"name":"Health Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laimonas","family":"Bartu\u0161is","sequence":"additional","affiliation":[{"name":"Health Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1146-6178","authenticated-orcid":false,"given":"Rolandas","family":"\u017dakelis","sequence":"additional","affiliation":[{"name":"Health Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8964-0738","authenticated-orcid":false,"given":"Vytautas","family":"Petkus","sequence":"additional","affiliation":[{"name":"Health Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arminas","family":"Ragauskas","sequence":"additional","affiliation":[{"name":"Health Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadas","family":"Lenkutis","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,17]]},"reference":[{"key":"ref_1","first-page":"3262","article-title":"Postoperative Cognitive Decline After Cardiac Surgery: A Narrative Review of Current Knowledge in 2019","volume":"25","author":"Glumac","year":"2019","journal-title":"Med. 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