{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:59:19Z","timestamp":1792454359114,"version":"4.5.0"},"reference-count":131,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Vertical rhythmic dyskinetic movements that are primarily drug-induced and affect solely the jaw, mouth, and lips without involving the tongue have been historically described as \u201crabbit\u201d syndrome (RS). Evidence on the unique features and implications of this disorder remains limited. This literature review aims to evaluate the clinical\u2013epidemiological profile, pathological mechanisms, and management of this movement disorder. Materials and Methods: Two reviewers identified and assessed relevant reports in six databases without language restriction published between 1972 and 2024. Results: A total of 85 articles containing 146 cases of RS were found. The mean frequency of RS among adults in psychiatric hospitals was 1.2% (range 0\u20134.4%). The mean age of affected patients was 49.2 (SD: 17.5), and 63.6% were females. Schizophrenia was the most frequent comorbidity found in 47.6%, followed by bipolar disorder (17.8%), major depressive disorder (10.3%), and obsessive\u2013compulsive disorder (3.7%). Five cases were idiopathic. The most common medications associated with RS were haloperidol (17%), risperidone (14%), aripiprazole (7%), trifluoperazine (5%), and sulpiride (5%). The mean duration of pharmacotherapy before RS was 21.4 weeks (SD: 20.6). RS occurred in association with drug-induced parkinsonism (DIP) in 27.4% and with tardive dyskinesia (TD) in 8.2% of cases. Antipsychotic modification and\/or anticholinergic drugs resulted in full or partial recovery in nearly all reported cases in which they were prescribed. Conclusions: RS occurs as a distinct drug-induced syndrome associated primarily but not exclusively with antipsychotics. Distinguishing RS from TD is important because the treatment options for the two disorders are quite different. By contrast, RS may be part of a spectrum of symptoms of DIP with similar course, treatment outcomes, and pathophysiology.<\/jats:p>","DOI":"10.3390\/medicina60081347","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T06:41:31Z","timestamp":1724049691000},"page":"1347","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Systematic Review of Oral Vertical Dyskinesia (\u201cRabbit\u201d Syndrome)"],"prefix":"10.3390","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6179-2177","authenticated-orcid":false,"given":"Jamir Pitton","family":"Rissardo","sequence":"first","affiliation":[{"name":"Neurology Department, Cooper University Hospital, Camden, NJ 08103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2943-2996","authenticated-orcid":false,"given":"Krish","family":"Kherajani","sequence":"additional","affiliation":[{"name":"Medicine Department, Terna Speciality Hospital, Navi Mumbai 400706, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilofar Murtaza","family":"Vora","sequence":"additional","affiliation":[{"name":"Medicine Department, Terna Speciality Hospital, Navi Mumbai 400706, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesh","family":"Yatakarla","sequence":"additional","affiliation":[{"name":"Medicine Department, Terna Speciality Hospital, Navi Mumbai 400706, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8024-2354","authenticated-orcid":false,"given":"Ana Let\u00edcia","family":"Fornari Caprara","sequence":"additional","affiliation":[{"name":"Neurology Department, Cooper University Hospital, Camden, NJ 08103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Ratliff","sequence":"additional","affiliation":[{"name":"Neurology Department, Thomas Jefferson University, Philadelphia, PA 19107, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley N.","family":"Caroff","sequence":"additional","affiliation":[{"name":"Psychiatric Department, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"SS-69","DOI":"10.1177\/07067437720176S213","article-title":"The Rabbit Syndrome. A Peculiar Extrapyramidal Reaction","volume":"17","author":"Villeneuve","year":"1972","journal-title":"Can. Psychiatr. Assoc. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1745-0179-3-6","article-title":"Newer Antipsychotics and the Rabbit Syndrome","volume":"3","author":"Fagiolini","year":"2007","journal-title":"Clin. Pract. Epidemiol. Ment. Health"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/070674377301800412","article-title":"Influence of Concentration and Motor Performance on Tardive Dyskinesia and Rabbit Syndrome","volume":"18","author":"Jus","year":"1973","journal-title":"Can. Psychiatr. Assoc. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.2174\/157488407781668820","article-title":"The Rabbit Syndrome: State of the Art","volume":"2","author":"Catena","year":"2007","journal-title":"Curr. Clin. Pharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2190\/PM.48.3.d","article-title":"Use of Psychotropic Drugs and Associated Dental Diseases","volume":"48","author":"Fratto","year":"2014","journal-title":"Int. J. Psychiatry Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"n160","DOI":"10.1136\/bmj.n160","article-title":"PRISMA 2020 explanation and elaboration: Updated guidance and exemplars for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1017\/pan.2018.26","article-title":"No Longer Lost in Translation: Evidence That Google Translate Works for Comparative Bag-of-Words Text Applications","volume":"26","author":"Schoonvelde","year":"2018","journal-title":"Polit. Anal."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ma, F. (2022). Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5). Encyclopedia of Gerontology and Population Aging, Springer.","DOI":"10.1007\/978-3-030-22009-9_419"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"A Method for Estimating the Probability of Adverse Drug Reactions","volume":"30","author":"Naranjo","year":"1981","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1176\/ajp.143.5.656","article-title":"Prevalence of the Rabbit Syndrome","volume":"143","author":"Yassa","year":"1986","journal-title":"Am. J. Psychiatry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/00005053-199304000-00009","article-title":"Prevalence of the Rabbit Syndrome in Hong Kong","volume":"181","author":"Chiu","year":"1993","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_12","first-page":"67","article-title":"Clinical Variants of Tardive Dyskinesia in Japan","volume":"45","author":"Inada","year":"1991","journal-title":"Jpn. J. Psychiatry Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/mds.870050317","article-title":"The Rabbit Syndrome","volume":"5","author":"Decina","year":"1990","journal-title":"Mov. Disord."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF00496058","article-title":"A Rating Scale for Tardive Dyskinesia","volume":"64","author":"Simpson","year":"1979","journal-title":"Psychopharmacology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"959","DOI":"10.3390\/clinpract13040087","article-title":"Overview of Movement Disorders Secondary to Drugs","volume":"13","author":"Rissardo","year":"2023","journal-title":"Clin. Pract."},{"key":"ref_16","first-page":"227","article-title":"Rabbit Syndrome, Antidepressant Use, and Cerebral Perfusion SPECT Scan Findings","volume":"16","author":"Fornazzari","year":"1991","journal-title":"J. Psychiatry Neurosci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000118825","article-title":"The Rabbit Syndrome and Antiparkinsonian Medication in Schizophrenic Patients","volume":"25","author":"Wada","year":"1992","journal-title":"Neuropsychobiology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3928\/02793695-20091204-02","article-title":"Psychotropic Medication-Induced Rabbit Syndrome","volume":"48","author":"Lindsey","year":"2010","journal-title":"J. Psychosoc. Nurs. Ment. Health Serv."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1176\/ajp.138.9.1243","article-title":"Extrapyramidal Reactions in Asians","volume":"138","author":"Binder","year":"1981","journal-title":"Am. J. Psychiatry"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"S150","DOI":"10.4103\/0028-3886.226464","article-title":"Risperidone Induced Rabbit Syndrome","volume":"66","author":"Rebello","year":"2018","journal-title":"Neurol. India"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1177\/0004867412460104","article-title":"Levosulpiride-Induced Rabbit Syndrome","volume":"47","author":"Garg","year":"2013","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1097\/JCP.0b013e3182683903","article-title":"Rabbit Syndrome Following Discontinuation of Paliperidone in a Patient with Schizoaffective Disorder","volume":"32","author":"Liang","year":"2012","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.4088\/JCP.v60n0709","article-title":"A Pilot Study on Risperidone Metabolism: The Role of Cytochromes P450 2D6 and 3A","volume":"60","author":"Bork","year":"1999","journal-title":"J. Clin. Psychiatry"},{"key":"ref_24","first-page":"138","article-title":"Studies on the Action of Certain Pharmacological Agents on Tardive Dyskinesia and on the Rabbit Syndrome","volume":"9","author":"Jus","year":"1974","journal-title":"Int. J. Clin. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1176\/ajp.134.11.1301","article-title":"The Effect of Benztropine Mesylate in the Rabbit Syndrome and Tardive Dyskinesia","volume":"134","author":"Sovner","year":"1977","journal-title":"Am. J. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1176\/ajp.137.5.627","article-title":"Physostigmine Test in the Rabbit Syndrome and Tardive Dyskinesia","volume":"137","author":"Weiss","year":"1980","journal-title":"Am. J. Psychiatry"},{"key":"ref_27","first-page":"98","article-title":"Rabbit Syndrome: Patchy Disapperance in Stage 1 Nrem Sleep","volume":"23","author":"Gangadhar","year":"1981","journal-title":"Indian J. Psychiatry"},{"key":"ref_28","first-page":"253","article-title":"The Rabbit Syndrome: A Clin Ical Study of Three Cases","volume":"14","author":"Kachi","year":"1981","journal-title":"Neurol. Med."},{"key":"ref_29","first-page":"557","article-title":"[The rabbit syndrome induced by sulpiride; a case report]","volume":"22","author":"Kakigi","year":"1982","journal-title":"Rinsho Shinkeigaku"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1176\/ajp.140.11.1519","article-title":"Recognition and Treatment of Rabbit Syndrome, an Uncommon Complication of Neuroleptic Therapies","volume":"140","author":"Todd","year":"1983","journal-title":"Am. J. Psychiatry"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1192\/bjp.157.2.293","article-title":"Rabbit Syndrome\u2014A Rare Complication of Long-Term Neuroleptic Medication","volume":"157","author":"Deshmukh","year":"1990","journal-title":"Br. J. Psychiatry"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1097\/00007611-199007000-00038","article-title":"Rabbit Syndrome Treated with Botulin","volume":"83","author":"Truong","year":"1990","journal-title":"South Med. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/gps.930060711","article-title":"Neuroleptic Side-Effects\u2014The \u201cRabbit Syndrome\u201d","volume":"6","author":"Almeida","year":"1991","journal-title":"Intern. J. Geriat. Psych."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/gps.930080910","article-title":"The Rabbit Syndrome: Occurrence in a Neuroleptic Naive Patient","volume":"8","author":"Kelvin","year":"1993","journal-title":"Intern. J. Geriat. Psych."},{"key":"ref_35","first-page":"663","article-title":"[A case of rabbit syndrome\u2014Its unique pharmacological feature]","volume":"33","author":"Nishiyama","year":"1993","journal-title":"Rinsho Shinkeigaku"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/sj.npp.1380158","article-title":"A Prospective Study of the Rabbit Syndrome","volume":"11","author":"Goswami","year":"1994","journal-title":"Neuropsychopharmacology"},{"key":"ref_37","first-page":"706","article-title":"Rabbit Syndrome: An Idiopathic Case with Tongue Tremor","volume":"46","author":"Poungvarin","year":"1994","journal-title":"Siriraj Med. J."},{"key":"ref_38","first-page":"212","article-title":"Rabbit Syndrome and Tardive Dyskinesia: Two Complications of Chronic Neuroleptic Treatment","volume":"56","author":"Schwartz","year":"1995","journal-title":"J. Clin. Psychiatry"},{"key":"ref_39","first-page":"176","article-title":"Rabbit Syndrome: An Uncommon Side Effect of Neuroleptics","volume":"39","author":"Gada","year":"1997","journal-title":"Indian J. Psychiatry"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00002826-199702000-00009","article-title":"Life-Threatening Dysphagia Following Prolonged Neuroleptic Therapy","volume":"20","author":"Hayashi","year":"1997","journal-title":"Clin. Neuropharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1192\/bjp.173.3.267b","article-title":"Risperidone-Induced Rabbit Syndrome","volume":"173","author":"Schwartz","year":"1998","journal-title":"Br. J. Psychiatry"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1081\/CLT-100102444","article-title":"Rabbit Syndrome Following Phenol Ingestion","volume":"37","author":"Kamijo","year":"1999","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0924-977X(98)00016-9","article-title":"Risperidone-Induced Rabbit Syndrome: An Unusual Movement Disorder Caused by an Atypical Antipsychotic","volume":"9","author":"Levin","year":"1999","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_44","first-page":"907","article-title":"[Idiopathic rabbit syndrome: A case report]","volume":"51","author":"Miwa","year":"1999","journal-title":"No To Shinkei"},{"key":"ref_45","first-page":"113","article-title":"A Case of Rabbit Syndrome","volume":"18","author":"Choi","year":"2000","journal-title":"J. Korean Neurol. Assoc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/000486700377","article-title":"Reversal of Rabbit Syndrome with Olanzapine","volume":"34","author":"Damodaran","year":"2000","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1192\/bjp.176.2.193","article-title":"Rabbit Syndrome Treated with Olanzapine","volume":"176","author":"Durst","year":"2000","journal-title":"Br. J. Psychiatry"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0924-977X(01)00095-5","article-title":"Withdrawal-Emergent Rabbit Syndrome during Dose Reduction of Risperidone","volume":"11","author":"Nishimura","year":"2001","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_49","first-page":"279","article-title":"Rabbit Syndrome\u2014An Acute Complication of Neuroleptic Medication","volume":"43","author":"Sethi","year":"2001","journal-title":"Indian J. Psychiatry"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1592\/phco.22.7.513.33669","article-title":"Rabbit Syndrome Secondary to Risperidone","volume":"22","author":"Hoy","year":"2002","journal-title":"Pharmacotherapy"},{"key":"ref_51","first-page":"38","article-title":"[Rabbit syndrome due to clebopride]","volume":"121","author":"Otero","year":"2003","journal-title":"Med. Clin."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"219","DOI":"10.4088\/JCP.v64n0215e","article-title":"Clozapine-Induced Rabbit Syndrome","volume":"64","author":"Sethi","year":"2003","journal-title":"J. Clin. Psychiatry"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.eurpsy.2004.06.022","article-title":"Risperidone-Induced Rabbit Syndrome in Mood Disorder","volume":"19","author":"Eren","year":"2004","journal-title":"Eur. Psychiatry"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/01.wnf.0000150870.52253.fe","article-title":"Induction of the Rabbit Syndrome Following Coadministration of Paroxetine, Perphenazine, and Amitriptyline","volume":"27","author":"Gourzis","year":"2004","journal-title":"Clin. Neuropharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1440-1614.2004.01412.x","article-title":"Aripiprazole-Induced Rabbit Syndrome","volume":"38","author":"Mendhekar","year":"2004","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.eurpsy.2004.11.014","article-title":"A Case of Rabbit Syndrome Treated with Quetiapine","volume":"20","author":"Altindag","year":"2005","journal-title":"Eur. Psychiatry"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/070674370505000618","article-title":"Rabbit Syndrome Induced by Combined Lithium and Risperidone","volume":"50","author":"Mendhekar","year":"2005","journal-title":"Can. J. Psychiatry"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1055\/s-2004-834759","article-title":"[Rabbit syndrome due to olanzapine]","volume":"32","author":"Sabolek","year":"2005","journal-title":"Psychiatr. Prax."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/01.wnf.0000191348.10375.41","article-title":"Dystonic Rabbit Syndrome from Citalopram","volume":"28","author":"Parvin","year":"2005","journal-title":"Clin. Neuropharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1345\/aph.1H086","article-title":"Methylphenidate-Induced Rabbit Syndrome","volume":"40","author":"Mendhekar","year":"2006","journal-title":"Ann. Pharmacother."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1176\/appi.ajp.163.1.160-a","article-title":"Aripiprazole-Induced Movement Disorder","volume":"163","author":"Zacher","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.schres.2008.01.008","article-title":"Aripiprazole-Induced Rabbit Syndrome in a Drug-Naive Schizophrenic Patient","volume":"103","author":"Gonidakis","year":"2008","journal-title":"Schizophr. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1097\/SMJ.0b013e3181884517","article-title":"Olanzapine-Induced Rabbit Syndrome","volume":"101","author":"Praharaj","year":"2008","journal-title":"South Med. J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/j.pnpbp.2008.09.001","article-title":"Quetiapine-Induced Rabbit Syndrome in a Patient with Bipolar Disorder","volume":"32","author":"Wu","year":"2008","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.4081\/mi.2009.e1","article-title":"Clozapine-Induced Rabbit Syndrome: A Case Report","volume":"1","author":"Hocaoglu","year":"2009","journal-title":"Ment. Illn."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1177\/0269881108098145","article-title":"Aripiprazole-Induced Rabbit Syndrome: A Case Report","volume":"24","author":"Caykoylu","year":"2010","journal-title":"J. Psychopharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"352.e23","DOI":"10.1176\/jnp.2010.22.3.352.e23","article-title":"Possible Rabbit Syndrome with Amisulpride","volume":"22","author":"Mendhekar","year":"2010","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"359","DOI":"10.5455\/bcp.20110926113728","article-title":"Ketiyapin Ile Birlikte Duloksetin Kullanan Hastada, Ketiyapin Doz Art\u0131r\u0131m\u0131 Sonras\u0131nda Geli\u015fen Rabbit Sendromu","volume":"21","author":"Cumurcu","year":"2011","journal-title":"Klin. Psikofarmakol. B\u00fclteni-Bull. Clin. Psychopharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/JCP.0b013e318219263d","article-title":"Paliperidone-Related Rabbit Syndrome","volume":"31","author":"Teng","year":"2011","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/JCP.0b013e31823f912a","article-title":"Parkinsonism and Rabbit Syndrome after Discontinuation of Low-Dose Ziprasidone and Concomitant Initiation of Sertraline","volume":"32","author":"Gray","year":"2012","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1097\/01.yic.0000423335.69967.a7","article-title":"Rabbit Syndrome Due to Olanzapine in a Patient with Bipolar Disorder","volume":"28","author":"Kunjithapatham","year":"2012","journal-title":"Intern. Clin. Psychopharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"A15","DOI":"10.1055\/s-0032-1326758","article-title":"Rabbit Syndrome and Akathisia in a Patient Treated with Risperidone","volume":"45","author":"Lay","year":"2012","journal-title":"Pharmacopsychiatry"},{"key":"ref_73","first-page":"44","article-title":"Risperidone-Induced Rabbit Syndrome: An Unusual Movement Disorder","volume":"78","author":"Sansare","year":"2012","journal-title":"N. Y. State Dent. J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"S740","DOI":"10.1016\/S0924-977X(14)71193-9","article-title":"A Case of \u201cRabbit Syndrome\u201d Induced by Amitriptyline","volume":"24","author":"Callista","year":"2014","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/8755122514536881","article-title":"Rabbit Syndrome Likely Induced by Escitalopram: A Case Report","volume":"30","author":"Nimber","year":"2014","journal-title":"J. Pharm. Technol."},{"key":"ref_76","first-page":"209","article-title":"Aripiprazole-Induced Rabbit Syndrome: How Safe Is Its Use in Adolescence?","volume":"4","author":"Dey","year":"2015","journal-title":"J. Depress. Anxiety"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/ams2.159","article-title":"Rabbit Syndrome after Taking Herbicide Containing 2-(4-Chloro2-Methylphenoxypropionic) Acid","volume":"3","author":"Kitamoto","year":"2016","journal-title":"Acute Med. Surg."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/dth.12227","article-title":"Rabbit Syndrome Because of Topical Minoxidil Foam","volume":"28","author":"Nagar","year":"2015","journal-title":"Dermatol. Ther."},{"key":"ref_79","first-page":"478","article-title":"Antipsychotic-Induced Rabbit Syndrome in a Pediatric Patient","volume":"68","author":"Nataraj","year":"2015","journal-title":"Can. J. Hosp. Pharm."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s10072-016-2509-x","article-title":"Rabbit Syndrome Associated with Medullary Compression by Vertebral Artery","volume":"37","author":"Park","year":"2016","journal-title":"Neurol. Sci."},{"key":"ref_81","first-page":"171","article-title":"Quetiapine-Related Rabbit Syndrome in a Patient with Bipolar Depression and Treated with Olanzapine-Fluoxetine Combination","volume":"66","author":"Belli","year":"2017","journal-title":"West Indian Med. J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e553","DOI":"10.4088\/JCP.16cr11157","article-title":"Lurasidone-Induced Rabbit Syndrome: A Case Report","volume":"78","author":"Reichenberg","year":"2017","journal-title":"J. Clin. Psychiatry"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/03007995.2016.1233100","article-title":"Rabbit Syndrome Developing during Peginterferon Alfa-2a Use in Chronic Hepatitis C","volume":"33","author":"Soyer","year":"2017","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_84","first-page":"193","article-title":"Fade-out of Perioral Tremor after Administration of L-DOPA: Role of Thalamus in Pathophysiology of Post-Stroke Rabbit Syndrome","volume":"2","author":"Kuo","year":"2018","journal-title":"MOJ Drug Des. Develop. Ther."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"134","DOI":"10.9758\/cpn.2019.17.1.134","article-title":"A Report of Rabbit Syndrome Who Benefited from Sigma 1 Agonist Fluvoxamine","volume":"17","author":"Albayrak","year":"2019","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"ref_86","first-page":"226","article-title":"Aripiprazole-Induced Rabbit Syndrome: A Case Report","volume":"29","author":"Eren","year":"2019","journal-title":"Psych. Clin. Psychopharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e12345","DOI":"10.1111\/appy.12345","article-title":"Rabbit Syndrome as a Side Effect Triggered by Amisulpride","volume":"11","author":"Ozberk","year":"2019","journal-title":"Asia Pac. Psychiatry"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s13760-020-01495-z","article-title":"Rabbit Syndrome in Anti-NMDAR Antibody Encephalitis: A Unique Association","volume":"120","author":"Datta","year":"2020","journal-title":"Acta Neurol. Belg."},{"key":"ref_89","first-page":"43","article-title":"Olanzapine-Induced Rabbit Syndrome: A Case Report","volume":"14","author":"Roy","year":"2020","journal-title":"Ind. J. Priv. Psychiatry"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"56","DOI":"10.5334\/tohm.674","article-title":"Functional Rabbit Syndrome: A Case Report","volume":"11","author":"Aniello","year":"2021","journal-title":"Tremor Other Hyperkinet. Mov."},{"key":"ref_91","first-page":"1037","article-title":"Risperidone-Induced Rabbit Syndrome: Video-Clinical Report","volume":"3","author":"Chaves","year":"2021","journal-title":"Ann. Clin. Case Stud."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4103\/aian.AIAN_398_20","article-title":"Rabbit Syndrome: An Asymmetrical Presentation","volume":"24","author":"Sastry","year":"2021","journal-title":"Ann. Indian Acad. Neurol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"S712","DOI":"10.1192\/j.eurpsy.2022.1835","article-title":"Amisulpride-Induced Late-Onset Rabbit Syndrome: Case Report and Literature Review","volume":"65","author":"Gundogmus","year":"2022","journal-title":"Eur. Psychiatry"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e363","DOI":"10.1097\/MJT.0000000000001195","article-title":"Fluoxetine-Induced \u201cRabbit Syndrome\u201d in a Child With Juvenile Obsessive-Compulsive Disorder","volume":"29","author":"Naguy","year":"2022","journal-title":"Am. J. Ther."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4103\/aomd.aomd_21_22","article-title":"Escitalopram-Induced Rabbit Syndrome","volume":"6","author":"Batra","year":"2023","journal-title":"Ann. Mov. Disord."},{"key":"ref_96","first-page":"2024","article-title":"Long-Acting Injectable Aripiprazole (Abilify Maintena) Induced Rabbit Syndrome: A Case Report and Review of The Literature","volume":"5","author":"Hsieh","year":"2024","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e209275","DOI":"10.1212\/WNL.0000000000209275","article-title":"Teaching Video NeuroImage: Rabbit Syndrome","volume":"102","author":"Huynh","year":"2024","journal-title":"Neurology"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"981","DOI":"10.2165\/00003495-199244060-00007","article-title":"A Clinical Guide to Antipsychotic Drugs","volume":"44","author":"Schwartz","year":"1992","journal-title":"Drugs"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2165\/00023210-200216010-00003","article-title":"Effects of Newer Antipsychotics on Extrapyramidal Function","volume":"16","author":"Tarsy","year":"2002","journal-title":"CNS Drugs"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Bhat, A.A., Gupta, G., Afzal, O., Kazmi, I., Al-Abbasi, F.A., Alfawaz Altamimi, A.S., Almalki, W.H., Alzarea, S.I., Singh, S.K., and Dua, K. (2023). Neuropharmacological Effect of Risperidone: From Chemistry to Medicine. Chem. Biol. Interact., 369.","DOI":"10.1016\/j.cbi.2022.110296"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1023\/A:1020464017021","article-title":"Safety and Tolerability: How Do Newer Generation \u201cAtypical\u201d Antipsychotics Compare?","volume":"73","author":"Tandon","year":"2002","journal-title":"Psychiatr. Q."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5334\/tohm.695","article-title":"Risk of Drug-Induced Movement Disorders with Newer Antipsychotic Agents","volume":"12","author":"Kannarkat","year":"2022","journal-title":"Tremor Other Hyperkinet. Mov."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1176\/ajp.152.1.122","article-title":"Fluoxetine and Extrapyramidal Side Effects","volume":"152","author":"Coulter","year":"1995","journal-title":"Am. J. Psychiatry"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"449","DOI":"10.4088\/JCP.v57n1002","article-title":"Movement Disorders Associated with the Serotonin Selective Reuptake Inhibitors","volume":"57","author":"Leo","year":"1996","journal-title":"J. Clin. Psychiatry"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4103\/iahs.iahs_71_19","article-title":"Oromandibular Dystonia Secondary to Methylphenidate: A Case Report and Literature Review","volume":"7","author":"Rissardo","year":"2020","journal-title":"Intern. Arch. Health Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0006-8993(96)01371-6","article-title":"Repeated Interferon-Alpha Administration Inhibits Dopaminergic Neural Activity in the Mouse Brain","volume":"747","author":"Shuto","year":"1997","journal-title":"Brain Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF00421217","article-title":"Dopaminergic Hypersensitivity and Cholinergic Hypofunction in the Pathophysiology of Tardive Dyskinesia","volume":"34","author":"Gerlach","year":"1974","journal-title":"Psychopharmacologia"},{"key":"ref_108","first-page":"53","article-title":"First Generation Antipsychotics: Pharmacokinetics, Pharmacodynamics, Therapeutic Effects and Side Effects: A Review","volume":"5","author":"Ayano","year":"2016","journal-title":"Res. Rev. J. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.eurpsy.2004.11.003","article-title":"Mechanisms of Action of Second Generation Antipsychotic Drugs in Schizophrenia: Insights from Brain Imaging Studies","volume":"20","author":"Laruelle","year":"2005","journal-title":"Eur. Psychiatry"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1176\/appi.ajp.157.4.514","article-title":"Relationship between Dopamine D(2) Occupancy, Clinical Response, and Side Effects: A Double-Blind PET Study of First-Episode Schizophrenia","volume":"157","author":"Kapur","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/npp.2010.228","article-title":"In Vivo Binding of Antipsychotics to D3 and D2 Receptors: A PET Study in Baboons with [11C]-(+)-PHNO","volume":"36","author":"Girgis","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"ref_112","first-page":"12","article-title":"Pharmacological Effects of Serotonin Reuptake Inhibitors","volume":"49","author":"Leonard","year":"1988","journal-title":"J. Clin. Psychiatry"},{"key":"ref_113","first-page":"42","article-title":"Potential Antidopaminergic Effects of Serotonin Reuptake Inhibitors","volume":"52","author":"Kim","year":"1991","journal-title":"J. Clin. Psychiatry"},{"key":"ref_114","first-page":"327","article-title":"Sigma Receptors [\u03c3Rs]: Biology in Normal and Diseased States","volume":"36","author":"Rousseaux","year":"2016","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"40","DOI":"10.5334\/tohm.188","article-title":"Palatal Tremor\u2014Pathophysiology, Clinical Features, Investigations, Management and Future Challenges","volume":"10","author":"Bhattacharjee","year":"2020","journal-title":"Tremor Other Hyperkinet. Mov."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0014-2999(69)90202-7","article-title":"The Effect of 5-Hydroxytryptamine and 5-Hydroxytryptophan on Extra-Pyramidal Function","volume":"6","author":"Ernst","year":"1969","journal-title":"Eur. J. Pharmacol."},{"key":"ref_117","first-page":"379","article-title":"Amphetamine Induced Stereotyped Behaviour Correlated with the Accumulation of O-Methylated Dopamine","volume":"177","author":"Jonas","year":"1969","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s40199-023-00489-5","article-title":"Atypical Extrapyramidal Manifestation of a Typical Antipsychotic with Serotonergic Antidepressant","volume":"32","author":"Singh","year":"2024","journal-title":"Daru"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"25055","DOI":"10.3390\/s151025055","article-title":"Quantitative Assessment of Parkinsonian Tremor Based on an Inertial Measurement Unit","volume":"15","author":"Dai","year":"2015","journal-title":"Sensors"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1136\/jnnp-2017-316115","article-title":"Sleep Patterns in Parkinson\u2019s Disease: Direct Recordings from the Subthalamic Nucleus","volume":"89","author":"Thompson","year":"2018","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1176\/ajp.129.6.765","article-title":"Tardive Dyskinesia and the Rabbit Syndrome during Wakefulness and Sleep","volume":"129","author":"Jus","year":"1972","journal-title":"Am. J. Psychiatry"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0001-2998(05)80079-0","article-title":"Studies of Central Nervous System Disorders with Single Photon Emission Computed Tomography and Positron Emission Tomography: Evolution over the Past 2 Decades","volume":"21","author":"Alavi","year":"1991","journal-title":"Semin. Nucl. Med."},{"key":"ref_123","first-page":"72","article-title":"Long Term Treatment of Tardive Dyskinesia","volume":"40","author":"Jus","year":"1979","journal-title":"J. Clin. Psychiatry"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2165\/00023210-200418040-00002","article-title":"Antipsychotic-Induced Rabbit Syndrome: Epidemiology, Management and Pathophysiology","volume":"18","author":"Schwartz","year":"2004","journal-title":"CNS Drugs"},{"key":"ref_125","first-page":"27","article-title":"Polygraphic Profile of Oral Tardive Dyskinesia and of Rabbit Syndrome: For Quantitative and Qualitative Evaluation","volume":"34","author":"Jus","year":"1973","journal-title":"Dis. Nerv. Syst."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1092852917000621","article-title":"Mechanism of Action of Vesicular Monoamine Transporter 2 (VMAT2) Inhibitors in Tardive Dyskinesia: Reducing Dopamine Leads to Less \u201cGo\u201d and More \u201cStop\u201d from the Motor Striatum for Robust Therapeutic Effects","volume":"23","author":"Stahl","year":"2018","journal-title":"CNS Spectr."},{"key":"ref_127","first-page":"10","article-title":"Oral Dyskinesia: A Clinical Overview","volume":"18","author":"Blanchet","year":"2005","journal-title":"Int. J. Prosthodont."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1111\/bcp.15884","article-title":"Drugs and Bruxism: A Study in the World Health Organization\u2019s Pharmacovigilance Database","volume":"89","author":"Montastruc","year":"2023","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1517\/14740338.2014.947262","article-title":"Psychotropic Drugs and Bruxism","volume":"13","author":"Falisi","year":"2014","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.bjoms.2020.02.018","article-title":"Oromandibular Dystonia: A Diagnosis Not to Miss","volume":"58","author":"Britton","year":"2020","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/mds.25478","article-title":"Tremor of the Eyes, or of the Head, in Parkinson\u2019s Disease?","volume":"28","author":"Leigh","year":"2013","journal-title":"Mov. Disord."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/8\/1347\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:38:53Z","timestamp":1760110733000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/8\/1347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,19]]},"references-count":131,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["medicina60081347"],"URL":"https:\/\/doi.org\/10.3390\/medicina60081347","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,19]]}}}