{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:11:34Z","timestamp":1766268694741,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Rijeka Trust Grand","award":["uniri-iskusni-biomed-23-213"],"award-info":[{"award-number":["uniri-iskusni-biomed-23-213"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>The patient we present here had many clinical, morphological, and laboratory findings characteristic of acute leukemia. During the course of the disease, the diagnosis changed from acute leukemia to chronic small B-cell lymphoproliferative disease, a blastoid variant of mantle cell lymphoma, and finally to atypical plasma cell leukemia. Atypical plasma cell leukemia is a rare condition with aggressive biological behavior. Our patient relapsed a short time after achieving complete remission, in spite of aggressive therapy and autologous stem cell transplantation. During relapse, it was possible to morphologically identify malignant cells as being of plasma cell origin, although immature and atypical. Atypical plasma cell leukemia presents a diagnostic challenge as it may mimic other neoplasms both morphologically and clinically. It is also recognized that plasma cell neoplasm immunophenotype may not be entirely specific for its lineage where common diagnostic biomarkers are applied by immunohistochemistry or flow cytometry. Where this is the case, only focused investigation for plasma cell lineage will be more informative. This patient has unusual clinical presentation, a nondescript morphology of the circulating plasma cells, as well as an immunophenotype, detected by the initial panels used for flow cytometry and immunohistochemistry, that was not entirely specific for plasma cells. Such cases present a good reminder of the diagnostic complexity of atypical plasma cell leukemia and emphasize that plasma cell differentiation needs to be interrogated in cases where the initial work-up shows unusual results.<\/jats:p>","DOI":"10.3390\/medicina60081351","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T06:07:35Z","timestamp":1724134055000},"page":"1351","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Atypical Plasma Cell Leukemia Mistaken for Acute Leukemia: A Case Report"],"prefix":"10.3390","volume":"60","author":[{"given":"Irena","family":"Seili-Bekafigo","sequence":"first","affiliation":[{"name":"Department of Cytology, Faculty of Medicine, University of Rijeka, Clinical Hospital Center Rijeka, 51000 Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1856-9804","authenticated-orcid":false,"given":"Emina","family":"Torlakovic","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5A2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tajana","family":"Grenko Malnar","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculty of Medicine, University of Rijeka, Clinical Hospital Center Rijeka, Kre\u0161imirova 42, 51000 Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0456-0350","authenticated-orcid":false,"given":"Marija Stani\u0107","family":"Dami\u0107","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculty of Medicine, University of Rijeka, Clinical Hospital Center Rijeka, Kre\u0161imirova 42, 51000 Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u017deljko","family":"Prka","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Hospital Dubrava, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koviljka","family":"Matu\u0161an Ilija\u0161","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Rijeka, Clinical Hospital Center Rijeka, 51000 Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1800-3552","authenticated-orcid":false,"given":"Ita","family":"Had\u017eisejdi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Rijeka, Clinical Hospital Center Rijeka, 51000 Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/17474086.2019.1598258","article-title":"An update on biology, diagnosis and treatment of primary plasma cell leukemia","volume":"12","author":"Musto","year":"2019","journal-title":"Expert Rev. 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