{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:21:35Z","timestamp":1760145695684,"version":"build-2065373602"},"reference-count":35,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bio&amp;Medical Technology Development Program of the National Research Foundation (NRF)","award":["RS-2024-00361688"],"award-info":[{"award-number":["RS-2024-00361688"]}]},{"name":"Korean government (MSIT)","award":["RS-2024-00361688"],"award-info":[{"award-number":["RS-2024-00361688"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background\/Objectives: A family history of Parkinson\u2019s disease (PD) is an important risk factor for developing PD. Because only a few studies have investigated the clinical characteristics of PD patients based on family history, this study compared the clinical characteristics of PD patients with and without a family history of PD. Methods: The study involved 356 patients with de novo PD. The data on the patients\u2019 PD family histories were obtained from the patients and their caregivers. Motor and non-motor PD symptoms were assessed using the appropriate scales. Results: Out of the 356 PD patients, 26 (7.3%) had a family history of PD. Compared with patients without a family history of PD, those with a family history of PD tended to be younger at diagnosis (67.9 years vs. 62.2 years, respectively; p = 0.009) and exhibited significantly more severe rigidity (p = 0.036). Motor subtype was not different between the PD patients with and without a family history. PD patients with a family history experienced significantly fewer falls\/cardiovascular symptoms within the Non-Motor Symptoms Scale domains (p = 0.001) compared to their counterparts, although this was not statistically significant upon adjusting for age (p = 0.119). Conclusions: In de novo PD patients, having a family history of PD is associated with a younger age at diagnosis and more severe rigidity.<\/jats:p>","DOI":"10.3390\/medicina60091378","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T12:38:43Z","timestamp":1724416723000},"page":"1378","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics of Patients with De Novo Parkinson\u2019s Disease and a Positive Family History"],"prefix":"10.3390","volume":"60","author":[{"given":"Hyunsoo","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology, Chonnam National University Hospital, Gwangju 61469, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-1881","authenticated-orcid":false,"given":"Seong-Min","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chonnam National University Hospital, Gwangju 61469, Republic of Korea"},{"name":"Department of Neurology, Chonnam National University Medical School, Gwangju 61469, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hak-Loh","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chonnam National University Hospital, Gwangju 61469, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Hyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chonnam National University Hospital, Gwangju 61469, Republic of Korea"},{"name":"Department of Neurology, Chonnam National University Medical School, Gwangju 61469, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6827-6730","authenticated-orcid":false,"given":"Byeong C.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chonnam National University Hospital, Gwangju 61469, Republic of Korea"},{"name":"Department of Neurology, Chonnam National University Medical School, Gwangju 61469, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1056\/NEJM199810083391506","article-title":"Parkinson\u2019s disease. First of two parts","volume":"339","author":"Lang","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1002\/mds.22786","article-title":"The nonmotor symptoms of Parkinson\u2019s disease\u2014An overview","volume":"25","author":"Lim","year":"2010","journal-title":"Mov. Disord."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00702-017-1686-y","article-title":"Epidemiology of Parkinson\u2019s disease","volume":"124","author":"Tysnes","year":"2017","journal-title":"J. Neural. Transm."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.yhbeh.2012.05.013","article-title":"Risk factors for Parkinson\u2019s disease may differ in men and women: An exploratory study","volume":"63","author":"Savica","year":"2013","journal-title":"Horm. Behav."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/mds.25945","article-title":"The prevalence of Parkinson\u2019s disease: A systematic review and meta-analysis","volume":"29","author":"Pringsheim","year":"2014","journal-title":"Mov. Disord."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.arr.2017.12.007","article-title":"The genetics of Parkinson disease","volume":"42","author":"Deng","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1136\/jnnp.65.5.781","article-title":"Genetic and environmental risk factors for Parkinson\u2019s disease in a Chinese population","volume":"65","author":"Chan","year":"1998","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jns.2003.09.014","article-title":"Multiple risk factors for Parkinson\u2019s disease","volume":"217","author":"Gorell","year":"2004","journal-title":"J. Neurol. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/(SICI)1096-8628(19991215)88:6<742::AID-AJMG29>3.0.CO;2-#","article-title":"Environmental, medical, and family history risk factors for Parkinson\u2019s disease: A New England-based case control study","volume":"88","author":"Taylor","year":"1999","journal-title":"Am. J. Med. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1034\/j.1600-0404.2002.1o040.x","article-title":"Familial and environmental risk factors in Parkinson\u2019s disease: A case-control study in north-east Italy","volume":"105","author":"Zorzon","year":"2002","journal-title":"Acta Neurol. Scand."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.parkreldis.2006.03.002","article-title":"Parkinson\u2019s disease and family history","volume":"12","author":"Sellbach","year":"2006","journal-title":"Park. Relat. Disord."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Torti, M., Fossati, C., Casali, M., De Pandis, M.F., Grassini, P., Radicati, F.G., Stirpe, P., Vacca, L., Iavicoli, I., and Leso, V. (2020). Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0243612"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jns.2010.05.024","article-title":"Lower prevalence of sleep disturbances in familial versus sporadic Parkinson\u2019s disease: A questionnaire based study","volume":"295","author":"Vibha","year":"2010","journal-title":"J. Neurol. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Chase, B.A., and Markopoulou, K. (2020). Olfactory Dysfunction in Familial and Sporadic Parkinson\u2019s Disease. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.00447"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1136\/jnnp-2012-302402","article-title":"A clinical and family history study of Parkinson\u2019s disease in heterozygous glucocerebrosidase mutation carriers","volume":"83","author":"McNeill","year":"2012","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease: A clinico-pathological study of 100 cases","volume":"55","author":"Hughes","year":"1992","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_18","unstructured":"Fahn, S., Marsden, C., Goldstein, M., and Calne, D. (1987). Unified Parkinson\u2019s disease rating scale. Recent Developments in Parkinson\u2019s Disease, McMillan Healthcare Information."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1212\/WNL.17.5.427","article-title":"Parkinsonism: Onset, progression and mortality","volume":"17","author":"Hoehn","year":"1967","journal-title":"Neurology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1002\/mds.21596","article-title":"The metric properties of a novel non-motor symptoms scale for Parkinson\u2019s disease: Results from an international pilot study","volume":"22","author":"Chaudhuri","year":"2007","journal-title":"Mov. Disord."},{"key":"ref_21","first-page":"300","article-title":"A validity study on the Korean mini-mental state examination (K-MMSE) in dementia patients","volume":"15","author":"Kang","year":"1997","journal-title":"J. Korean. Neurol. Assoc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000395074","article-title":"Assessment of depression; the depression inventory","volume":"7","author":"Beck","year":"1974","journal-title":"Mod. Probl. Pharmacopsychiatry"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jns.2018.01.013","article-title":"Comparison of clinical features among Parkinson\u2019s disease subtypes: A large retrospective study in a single center","volume":"386","author":"Konno","year":"2018","journal-title":"J. Neurol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/mds.20513","article-title":"Clinical characteristics in early Parkinson\u2019s disease in a central California population-based study","volume":"20","author":"Kang","year":"2005","journal-title":"Mov. Disord."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/ana.23687","article-title":"Meta-analysis of early nonmotor features and risk factors for Parkinson disease","volume":"72","author":"Noyce","year":"2012","journal-title":"Ann. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/mds.27352","article-title":"Genotype-Phenotype Relations for the Parkinson\u2019s Disease Genes Parkin, PINK1, DJ1: MDSGene Systematic Review","volume":"33","author":"Kasten","year":"2018","journal-title":"Mov. Disord."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S1474-4422(19)30287-X","article-title":"The genetic architecture of Parkinson\u2019s disease","volume":"19","author":"Blauwendraat","year":"2020","journal-title":"Lancet Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1093\/brain\/awaa167","article-title":"The role of genetics in Parkinson\u2019s disease: A large cohort study in Chinese mainland population","volume":"143","author":"Zhao","year":"2020","journal-title":"Brain"},{"key":"ref_29","first-page":"848","article-title":"Familial aggregation of Parkinson disease: A comparative study of early-onset and late-onset disease","volume":"59","author":"Payami","year":"2020","journal-title":"Arch. Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/mds.26166","article-title":"Relationship of age of onset and family history in Parkinson disease","volume":"30","author":"Barrett","year":"2015","journal-title":"Mov. Disord."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/mds.26856","article-title":"Familial aggregation of Parkinson\u2019s disease may affect progression of motor symptoms and dementia","volume":"32","author":"Gaare","year":"2017","journal-title":"Mov. Disord."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1212\/WNL.52.9.1876","article-title":"Familial aggregation of Parkinson\u2019s disease: A population-based case-control study in Europe. EUROPARKINSON Study Group","volume":"52","author":"Elbaz","year":"1999","journal-title":"Neurology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1002\/mds.20061","article-title":"Differences in age at onset and familial aggregation between clinical types of idiopathic Parkinson\u2019s disease","volume":"19","author":"Korchounov","year":"2004","journal-title":"Mov. Disord."},{"key":"ref_34","first-page":"115","article-title":"Clinical features of familial Parkinson\u2019s disease in Thai patients","volume":"17","author":"Prueksaritanond","year":"2009","journal-title":"Qual. Prim. Care"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.parkreldis.2014.02.013","article-title":"Comparing clinical features of young onset, middle onset and late onset Parkinson\u2019s disease","volume":"20","author":"Mehanna","year":"2014","journal-title":"Park. Relat. Disord."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/9\/1378\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:42:04Z","timestamp":1760110924000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/60\/9\/1378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,23]]},"references-count":35,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["medicina60091378"],"URL":"https:\/\/doi.org\/10.3390\/medicina60091378","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2024,8,23]]}}}